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View Structure Prediction Details

Protein: PHB1
Organism: Saccharomyces cerevisiae
Length: 287 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHB1.

Description E-value Query
Range
Subject
Range
PHB_RAT - Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1
tr|G3HJP6|G3HJP6... - Prohibitin OS=Cricetulus griseus GN=I79_010895 PE=4 SV=1
PHB_MOUSE - Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1
1.0E-71 [4..274] [2..272]
gi|61362617, gi|... - gi|61362624|gb|AAX42254.1| prohibitin [synthetic construct], gi|61362617|gb|AAX42253.1| prohibitin [...
HGNC:8912|MIM:17... - null
PHB - prohibitin
PHB_BOVIN - Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1
gi|158906128, gi... - gi|160333845|ref|NP_001103918.1| prohibitin [Felis catus], gi|158906128|gb|ABW82705.1| prohibitin [F...
gi|158442066, gi... - gi|158819069|ref|NP_001103649.1| prohibitin [Canis lupus familiaris], gi|158442066|gb|ABW38778.1| pr...
gi|109114258, gi... - gi|109114260|ref|XP_001093569.1| PREDICTED: similar to prohibitin isoform 7 [Macaca mulatta], gi|109...
ENSCJAT00000014086 - null
gi|114666273, gi... - gi|55646807|ref|XP_511949.1| PREDICTED: prohibitin isoform 7 [Pan troglodytes], gi|114666277|ref|XP_...
2.0E-71 [4..274] [2..272]
gi|220944624, gi... - gi|220954406|gb|ACL89746.1| l(2)37Cc-PA [synthetic construct], gi|220944624|gb|ACL84855.1| l(2)37Cc-...
gi|190657476, gi... - gi|194879728|ref|XP_001974289.1| GG21649 [Drosophila erecta], gi|190657476|gb|EDV54689.1| GG21649 [D...
l(2)37Cc-PA, l(2... - The gene lethal (2) 37Cc is referred to in FlyBase by the symbol Dmel\l(2)37Cc (CG10691, FBgn0002031...
gi|194134208, gi... - gi|195345029|ref|XP_002039078.1| GM17028 [Drosophila sechellia], gi|194134208|gb|EDW55724.1| GM17028...
gi|195484379, gi... - gi|195484379|ref|XP_002090669.1| GE12669 [Drosophila yakuba], gi|194176770|gb|EDW90381.1| GE12669 [D...
gi|194191900, gi... - gi|195580095|ref|XP_002079891.1| GD21777 [Drosophila simulans], gi|194191900|gb|EDX05476.1| GD21777 ...
2.0E-68 [4..274] [2..272]
PHB1 - Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane ...
PHB1_YEAST - Prohibitin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHB1 PE=1 SV=2
gi|207345078 - gi|207345078|gb|EDZ72016.1| YGR132Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190406850 - gi|190406850|gb|EDV10117.1| prohibitin [Saccharomyces cerevisiae RM11-1a]
6.0E-67 [1..287] [1..287]
PHB4_ARATH - Prohibitin-4, mitochondrial OS=Arabidopsis thaliana GN=PHB4 PE=1 SV=1
3.0E-66 [4..272] [7..275]
gi|2055454 - gi|2055454|gb|AAB53231.1| prohibitin-like molecule TC-PRO-1 [Toxocara canis]
2.0E-63 [1..274] [1..274]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-63 [1..270] [1..273]
gi|238014248, gi... - gi|7716458|gb|AAF68385.1|AF236369_1 prohibitin [Zea mays], gi|238014248|gb|ACR38159.1| unknown [Zea ...
7.0E-62 [1..270] [1..273]

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Predicted Domain #1
Region A:
Residues: [1-179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSAKLIDV ITKVALPIGI IASGIQYSMY DVKGGSRGVI FDRINGVKQQ VVGEGTHFLV  60
   61 PWLQKAIIYD VRTKPKSIAT NTGTKDLQMV SLTLRVLHRP EVLQLPAIYQ NLGLDYDERV 120
  121 LPSIGNEVLK SIVAQFDAAE LITQREIISQ KIRKELSTRA NEFGIKLEDV SITHMTFGP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [208-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERQASVIRAE GEAESAEFIS KALAKVGDGL LLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 877.529817
Match: 1lu7A_
Description: No description for 1lu7A_ was found.

Predicted Domain #2
Region A:
Residues: [180-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFTKAVEQKQ IAQQDAERAK FLVEKAEQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [241-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRLEASKDIA QTLANSSNVV YLPSQHSGGG NSESSGSPNS LLLNIGR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 877.529817
Match: 1lu7A_
Description: No description for 1lu7A_ was found.

Predicted functions:

Term Confidence Notes
binding 2.10215477176861 bayes_pls_golite062009
protein binding 0.769979871341236 bayes_pls_golite062009
structural molecule activity 0.591437172549816 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [198-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKFLVEKAEQ ERQASVIRAE GEAESAEFIS KALAKVGDGL LLIRRLEASK DIAQTLANSS  60
   61 NVVYLPSQHS GGGNSESSGS PNSLLLNIGR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle