YRC Public Data Repository - Protein Structure Prediction

Protein:	CAX4
Organism:	Saccharomyces cerevisiae
Length:	239 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAX4.

Description	E-value	Query Range	Subject Range
CAX4_YEAST - Dolichyldiphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAX4 PE=1 SV=1 gi\|190406938 - gi\|190406938\|gb\|EDV10205.1\| dolichyldiphosphatase [Saccharomyces cerevisiae RM11-1a] gi\|151943320 - gi\|151943320\|gb\|EDN61633.1\| dolichyl pyrophosphate phosphatase [Saccharomyces cerevisiae YJM789] CAX4 - Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleave...	1.0E-47	[1..239]	[1..239]
DOPP1_MOUSE - Dolichyldiphosphatase 1 OS=Mus musculus GN=Dolpp1 PE=2 SV=1	5.0E-35	[16..230]	[15..229]
gi\|15724220, gi\|... - gi\|23505931\|gb\|AAN28825.1\| At2g01180/F10A8.6 [Arabidopsis thaliana], gi\|15724220\|gb\|AAL06503.1\|AF412...	2.0E-33	[18..216]	[78..303]
gi\|14327944 - gi\|14327944\|gb\|AAH09196.1\| Phosphatidic acid phosphatase type 2B [Homo sapiens] gi\|123998537, gi... - gi\|123998537\|gb\|ABM86870.1\| phosphatidic acid phosphatase type 2B [synthetic construct], gi\|12399369...	2.0E-30	[6..209]	[57..301]
pdf1 - palmitoyl protein thioesterase-dolichol pyrophosphate phosphatase fusion 1 PDF1_SCHPO - Palmitoyl-protein thioesterase-dolichyl pyrophosphate phosphatase fusion 1 OS=Schizosaccharomyces po...	4.0E-30	[11..229]	[387..596]
PLPP3_RAT - Phospholipid phosphatase 3 OS=Rattus norvegicus GN=Plpp3 PE=1 SV=1	5.0E-30	[6..209]	[57..302]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-28	[17..225]	[11..215]

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Predicted Domain #1

Region A:
Residues: [1-239]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSTAAAINP NPNVIPFDDT YILYDSHDFL SFLSAYFSLM PILVLAFYLS WFIITRELEA  60
   61 CIVAFGQLMN EIFNNVIKNI IKQPRPVSFG ASFQNDTIRS GYGMPSAHSQ FMGFCFTYNS 120
  121 LKIYTSWKNL NFLEKCIFSG ALALLSFCVC FSRVYLHYHN LDQVIVGFSV GALTGSLYFF 180
  181 IVGIIRELGL INWFLKLRIV RLFYMTDSYN LAPLTLKENY EAYWKRINQR SFNDKSKRD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	1d2tA_
Description:	Bacterial acid phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.767627914425245	bayes_pls_golite062009
phosphatase activity	0.722810330266611	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.534563060036778	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: