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View Structure Prediction Details

Protein: TFG2
Organism: Saccharomyces cerevisiae
Length: 400 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFG2.

Description E-value Query
Range
Subject
Range
gi|639703 - gi|639703|gb|AAA61642.1| transcription initiation factor TFIIF middle subunit
0.0 [1..400] [1..400]
T2FB_XENLA - General transcription factor IIF subunit 2 OS=Xenopus laevis GN=gtf2f2 PE=2 SV=1
1.0E-81 [56..363] [7..262]
T2FB_SCHPO - Transcription initiation factor IIF subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
tfg2 - transcription factor TFIIF complex beta subunit Tfg2
3.0E-55 [163..356] [59..253]
gi|15231173 - gi|15231173|ref|NP_190795.1| ATP binding / RNA polymerase II transcription factor [Arabidopsis thali...
4.0E-50 [208..361] [212..364]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-48 [208..361] [212..376]
gi|19073998, gi|... - gi|19073998|ref|NP_584604.1| TRANSCRIPTION INITIATION FACTOR TFIIF BETA SUBUNIT [Encephalitozoon cun...
gi|19073998 - ref|NP_584604.1| TRANSCRIPTION INITIATION FACTOR TFIIF BETA SUBUNIT [Encephalitozoon cuniculi]
9.0E-46 [198..357] [74..228]

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Predicted Domain #1
Region A:
Residues: [1-194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGSAGAPA LSNNSTNSVA KEKSGNISGD EYLSQEEEVF DGNDIENNET KVYEESLDLD  60
   61 LERSNRQVWL VRLPMFLAEK WRDRNNLHGQ ELGKIRINKD GSKITLLLNE NDNDSIPHEY 120
  121 DLELTKKVVE NEYVFTEQNL KKYQQRKKEL EADPEKQRQA YLKKQEREEE LKKKQQQQKR 180
  181 RNNRKKFNHR VMTD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.502279
Match: 1f3uA_
Description: TFIIF beta subunit, Rap30
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA polymerase II transcription factor activity 4.06672086326535 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [195-269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDGRDRYIPY VKTIPKKTAI VGTVCHECQV MPSMNDPNYH KIVEQRRNIV KLNNKERITT  60
   61 LDETVGVTMS HTGMS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.540 d.13.1 HIT-like
View Download 0.781 d.58.49 YajQ-like
View Download 0.702 a.5.6 Hypothetical protein MTH1615
View Download 0.634 d.95.1 Glucose permease domain IIB
View Download 0.577 d.58.24 CheY-binding domain of CheA
View Download 0.540 d.74.2 C-terminal domain of arginine repressor
View Download 0.536 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.523 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.512 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.502 d.58.49 YajQ-like
View Download 0.495 d.58.5 GlnB-like
View Download 0.474 d.58.17 Metal-binding domain
View Download 0.470 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.469 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.462 d.58.3 Protease propeptides/inhibitors
View Download 0.447 d.68.3 SirA-like
View Download 0.419 d.15.7 Immunoglobulin-binding domains
View Download 0.417 d.58.7 RNA-binding domain, RBD
View Download 0.402 a.4.5 "Winged helix" DNA-binding domain
View Download 0.400 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.384 a.4.1 Homeodomain-like
View Download 0.379 a.39.1 EF-hand
View Download 0.372 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.366 d.68.7 R3H domain
View Download 0.361 d.15.7 Immunoglobulin-binding domains
View Download 0.361 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.350 d.52.7 Ribosome-binding factor A, RbfA
View Download 0.346 d.52.4 YhbC-like, N-terminal domain
View Download 0.340 a.64.1 Saposin
View Download 0.338 d.58.48 MTH1187-like
View Download 0.334 a.4.5 "Winged helix" DNA-binding domain
View Download 0.325 d.45.1 ClpS-like
View Download 0.315 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.299 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.276 d.74.5 Hypothetical protein Yml108w
View Download 0.271 d.64.1 eIF1-like
View Download 0.269 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.265 d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.259 d.15.3 MoaD/ThiS
View Download 0.252 a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
View Download 0.249 d.58.10 Acylphosphatase-like
View Download 0.248 g.53.1 TAZ domain
View Download 0.243 d.26.1 FKBP-like
View Download 0.237 c.47.1 Thioredoxin-like
View Download 0.234 b.1.1 Immunoglobulin
View Download 0.228 g.7.1 Snake toxin-like
View Download 0.227 d.68.4 YhbY-like
View Download 0.225 b.71.1 Glycosyl hydrolase domain
View Download 0.217 a.4.5 "Winged helix" DNA-binding domain
View Download 0.212 d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.211 b.71.1 Glycosyl hydrolase domain
View Download 0.208 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.204 a.4.5 "Winged helix" DNA-binding domain
View Download 0.204 d.95.2 Homing endonucleases
View Download 0.203 b.1.2 Fibronectin type III
View Download 0.201 d.58.18 Regulatory domain in the aminoacid metabolism

Predicted Domain #3
Region A:
Residues: [270-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSDNSNFLK VGREKAKSNI KSIRMPKKEI LDYLFKLFDE YDYWSLKGLK ERTRQPEAHL  60
   61 KECLDKVATL VKKGPYAFKY TLRPEYKKLK EEERKATLGE LADEQTGSAG DNAQGDAEAD 120
  121 LEDEIEMEDV V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.9794
Match: 1bby__
Description: DNA-binding domain from rap30
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle