YRC Public Data Repository - Protein Structure Prediction

Protein:	NCS6
Organism:	Saccharomyces cerevisiae
Length:	193 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NCS6.

Description	E-value	Query Range	Subject Range
gi\|7445411, gi\|2... - pir\|\|S64230 hypothetical protein YGL211w - yeast (Saccharomyces cerevisiae), gi\|2507513\|sp\|P53088\|YG...	2.0E-48	[1..192]	[1..197]
gi\|15224850, gi\|... - pir\|\|T02383 hypothetical protein At2g44270 [imported] - Arabidopsis thaliana, gi\|3128173\|gb\|AAC1607...	2.0E-41	[12..192]	[4..189]
SPBC2G5.03 - ATP binding protein CTU1_SCHPO - Cytoplasmic tRNA 2-thiolation protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nc...	4.0E-40	[19..192]	[3..182]
gi\|19173081, gi\|... - gi\|19173081\|ref\|NP_597632.1\| similarity to HYPOTHETICAL PROTEIN YGW1_yeast [Encephalitozoon cuniculi... gi\|19173081 - gi\|19173081\|ref\|NP_597632.1\| similarity to HYPOTHETICAL PROTEIN YGW1_yeast [Encephalitozoon cuniculi...	3.0E-37	[22..192]	[3..178]
tut-1 - status:Confirmed UniProt:O76365 protein_id:AAC19193.1	7.0E-37	[15..192]	[3..187]
gi\|220950426 - gi\|220950426\|gb\|ACL87756.1\| CG8078-PA [synthetic construct] CG8078-PA - This gene is referred to in FlyBase by the symbol Dmel\CG8078 (CG8078, FBgn0033375). It is a protein...	7.0E-37	[21..192]	[4..180]
V136_DICDI - UPF0021 protein VEG136 - Dictyostelium discoideum (Slime mold)	8.0E-36	[17..192]	[5..185]
CTU1_MOUSE - Cytoplasmic tRNA 2-thiolation protein 1 OS=Mus musculus GN=Ctu1 PE=2 SV=1	3.0E-35	[20..192]	[4..184]
GUAA_BACHD - Putative GMP synthase [glutamine-hydrolyzing] OS=Bacillus halodurans GN=guaA PE=3 SV=1 GUAA_BACHD - Putative GMP synthase [glutamine-hydrolyzing] OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 1819...	2.0E-34	[26..187]	[177..335]
gi\|2648962, gi\|1... - gi\|2648962\|gb\|AAB89651.1\| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304], gi\|11499... gi\|7429997 - pir\|\|B69449 conserved hypothetical protein AF1595 - Archaeoglobus fulgidus	2.0E-34	[21..192]	[3..176]

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Predicted Domain #1

Region A:
Residues: [1-193]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFTAPSDPV NKPTKVKVSQ LCELCHSRKA LIRRPKNLSK LCKQCFCLVF ETEIHNTIVA  60
   61 NNLFQRGEKV AVGASGGKDS TVLAHMLKLL NDRYDYGIEI VLLSIDEGII GYRDDSLATV 120
  121 KRNQQQYGLP LEIFSFKDLY DWTMDEIVSV AGIRNSCTYC GVFRRQSLDR GAAKWAYLTL 180
  181 SPATMQTIWQ RQY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.69897
Match:	1gpmA_
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.298809327772818	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: