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View Structure Prediction Details

Protein: MDS3
Organism: Saccharomyces cerevisiae
Length: 1487 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDS3.

Description E-value Query
Range
Subject
Range
PMD1_YEAST - Negative regulator of sporulation PMD1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=P...
PMD1 - Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expr...
0.0 [1..1479] [1..1594]
gi|25496719 - pir||B97033 uncharacterized protein, related to enterotoxins of other Clostridiales [imported] - Clo...
gi|15894364, gi|... - gi|15894364|ref|NP_347713.1| hypothetical protein CAC1079 [Clostridium acetobutylicum ATCC 824], gi|...
7.0E-67 [576..793] [62..257]
RAL2_SCHPO - Protein ral2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ral2 PE=1 SV=1
ral2 - Ras guanyl-nucleotide exchange factor Ral2
8.0E-60 [107..462] [29..413]
gi|10434800 - gi|10434800|dbj|BAB14382.1| unnamed protein product [Homo sapiens]
7.0E-52 [45..331] [141..407]

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Predicted Domain #1
Region A:
Residues: [1-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLLQPSTCF CYPLKLPPLP LTSDSNEFDE CARKRLTLDY RTGSAVTLTR SNIFVHGGLT  60
   61 IPLNLPVVNS MQLQKELILF FAKEKNNG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.341 g.52.1 Inhibitor of apoptosis (IAP) repeat
View Download 0.471 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.339 b.101.1 Ribonuclease domain of colicin E3
View Download 0.336 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.422 d.82.1 Copper amine oxidase, domain N
View Download 0.327 b.1.1 Immunoglobulin
View Download 0.289 d.50.3 PI-Pfui intein middle domain
View Download 0.263 d.58.17 Metal-binding domain
View Download 0.243 d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.228 a.39.1 EF-hand
View Download 0.225 a.118.8 TPR-like

Predicted Domain #2
Region A:
Residues: [89-334]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSFRNLNEWI SKETFFLDLM SRTWYRVKTS FDQRTEELLK AESSSAKADN DTNEIRTDIK  60
   61 KGKSLESPLK ERLFHSLCYL DGCLYIFGGL TVSPQSGYEL IATNELWKLD LNTKKWSLLS 120
  121 DDPQIARRFN HTMHVKNENN DNRDTKLIIV GGLNNMDQPV KKIDIYNISQ NCWHPKTIPK 180
  181 QPMEITTNVN GIPLALSKDQ NFSILVENNE ANVPALAFYM RSDQIDEYLG KDSSKIKENS 240
  241 PIVALP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1gof__
Description: Galactose oxidase, C-terminal domain; Galactose oxidase, N-terminal domain; Galactose oxidase, central domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [335-553]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLSESQGIRM PSNPALPKKL LNVPYELLAP TGDYFGFNII IGGFHPNYQS SNFHCFIYDI  60
   61 NSGKWSRVRT ACPDCDINKH RFWRVFVWKS HHQTILLGTK TDDYYSPSVQ RFDHLSTFGL 120
  121 PLVNIFNKTI QLPHHKISAS SLPIPIENFA KHKDTPLKKV SFTSSATSQF ENYIRYIAPP 180
  181 LEMSSIQSVF PPYAMVLGKD ALEIYGKPLS DFEFITSEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [554-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSIGIPCYLL RKRWGRYFDM LLSQSYTKVC ADYETTDTQS TLIKFSPHSS RNSSKAVRQE  60
   61 GRLSSSGSLD NYFEKNFPIF ARTSVSEAQN TQPQVANADA KAPNTPSTSD EPSSSSSSDL 120
  121 YSTPHYQRNN DEEDDEDPVS PKPVSKSNSI YRPIRKTESS STTSSSNGMI FRVPFKEKAA 180
  181 VTSNTEALLE SNLSLQELSR RRSSLMSIPS GELLRSSISE AEHQRRASHP LTSSPLFEDS 240
  241 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [794-1487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTPCGKQLQQ LQQHTIQNPH NHLSPRRFSR SARSSISYVS SSSDRRGNSI SSRSTSDSFG  60
   61 TPPVLGVLNV PLPPQTREPN EPPPPCPAMS TGSNTRRSNT LTDYMHSNKA SPFSSRRSSH 120
  121 IGRRSSTPET ENAFSATPRA SLDGQMLGKS LKEGSTSQYT QPRMNSFPKA NETIQTPTSS 180
  181 NNEWSRQSVT SNTDSFDSLQ SNFALELEPL LTPRSLYMPW PTSTVRAFAE FFYTGQVNSK 240
  241 WLLAPVALDL LVMAKIYEIP LLYKLILEVL YSILAKKEES LSLICTSLME TFRTKTLNSY 300
  301 KGDEEKTNTY LTSNDNYQEL LKLKVSLENI DNGYYDPDLL RKQSRAQSSS TQESSGSANG 360
  361 EKTATGAGSL ETSSTNVPTV FAGGPRDSHN SVGSIGFPNS MNIQGSRRST SGFSPRVKMK 420
  421 SSLSKEIDPK TFYEEYEPKE GKSFDDNDDQ QTNIGSFNLH LFDMNYGSIS SSSTNSISSS 480
  481 DLEEKEEQEQ LQDLLEIERE DSAEILDARF RNKEDDKVTK DISNDKKRNY LPHEKNNLKA 540
  541 KEGKETRDVR EEEEEFDFGL GMLSLNKIKR EAKHVDKVDD SVDPLFKSSA FPQSPIRAYG 600
  601 STTRTSSASG KPFRDNRSFN AFSVLTLENM ASANALPPVD YVIKSIYRTT VLVNDIRLMV 660
  661 RCMDCIELSK NLRALKKKTM EDISKLKGIS KPSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [794-884]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTPCGKQLQQ LQQHTIQNPH NHLSPRRFSR SARSSISYVS SSSDRRGNSI SSRSTSDSFG  60
   61 TPPVLGVLNV PLPPQTREPN EPPPPCPAMS T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [885-959]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNTRRSNTL TDYMHSNKAS PFSSRRSSHI GRRSSTPETE NAFSATPRAS LDGQMLGKSL  60
   61 KEGSTSQYTQ PRMNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [960-1194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPKANETIQT PTSSNNEWSR QSVTSNTDSF DSLQSNFALE LEPLLTPRSL YMPWPTSTVR  60
   61 AFAEFFYTGQ VNSKWLLAPV ALDLLVMAKI YEIPLLYKLI LEVLYSILAK KEESLSLICT 120
  121 SLMETFRTKT LNSYKGDEEK TNTYLTSNDN YQELLKLKVS LENIDNGYYD PDLLRKQSRA 180
  181 QSSSTQESSG SANGEKTATG AGSLETSSTN VPTVFAGGPR DSHNSVGSIG FPNSM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1195-1326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIQGSRRSTS GFSPRVKMKS SLSKEIDPKT FYEEYEPKEG KSFDDNDDQQ TNIGSFNLHL  60
   61 FDMNYGSISS SSTNSISSSD LEEKEEQEQL QDLLEIERED SAEILDARFR NKEDDKVTKD 120
  121 ISNDKKRNYL PH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1327-1487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKNNLKAKEG KETRDVREEE EEFDFGLGML SLNKIKREAK HVDKVDDSVD PLFKSSAFPQ  60
   61 SPIRAYGSTT RTSSASGKPF RDNRSFNAFS VLTLENMASA NALPPVDYVI KSIYRTTVLV 120
  121 NDIRLMVRCM DCIELSKNLR ALKKKTMEDI SKLKGISKPS P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle