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View Structure Prediction Details

Protein: ARO2
Organism: Saccharomyces cerevisiae
Length: 376 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARO2.

Description E-value Query
Range		 Subject
Range
ARO2 - Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshik...
gi|190407094 - gi|190407094|gb|EDV10361.1| chorismate synthase [Saccharomyces cerevisiae RM11-1a]
gi|207345435 - gi|207345435|gb|EDZ72257.1| YGL148Wp-like protein [Saccharomyces cerevisiae AWRI1631]
AROC_YEAST - Chorismate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO2 PE=1 SV=1
 0.0 [1..376] [1..376]
gi|497783 - gi|497783|gb|AAA21830.1| 2,3-dihydroxybenzoic acid [Listonella anguillarum]
 0.0 [2..371] [15..364]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [2..371] [15..364]
AROC1_SOLLC - Chorismate synthase 1, chloroplastic OS=Solanum lycopersicum GN=CS1 PE=2 SV=1
 0.0 [2..368] [57..415]
AROC_ARATH - Chorismate synthase, chloroplastic OS=Arabidopsis thaliana GN=EMB1144 PE=2 SV=2
 0.0 [2..368] [53..411]
AROC_CAPSE - Chorismate synthase, chloroplastic OS=Capnoides sempervirens PE=1 SV=1
 0.0 [2..368] [61..419]
AROC_SYNY3 - Chorismate synthase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=aroC PE=3 SV=2
AROC_SYNY3 - Chorismate synthase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=aroC PE=3 SV=2
gi|1075619 - pir||A49316 chorismate synthase (EC 4.2.3.5) - Synechocystis sp. (strain PCC 6803)
 0.0 [2..368] [3..358]

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Predicted Domain #1
Region A:
Residues: [1-376] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTFGKLFRV TTYGESHCKS VGCIVDGVPP GMSLTEADIQ PQLTRRRPGQ SKLSTPRDEK  60
   61 DRVEIQSGTE FGKTLGTPIA MMIKNEDQRP HDYSDMDKFP RPSHADFTYS EKYGIKASSG 120
  121 GGRASARETI GRVASGAIAE KFLAQNSNVE IVAFVTQIGE IKMNRDSFDP EFQHLLNTIT 180
  181 REKVDSMGPI RCPDASVAGL MVKEIEKYRG NKDSIGGVVT CVVRNLPTGL GEPCFDKLEA 240
  241 MLAHAMLSIP ASKGFEIGSG FQGVSVPGSK HNDPFYFEKE TNRLRTKTNN SGGVQGGISN 300
  301 GENIYFSVPF KSVATISQEQ KTATYDGEEG ILAAKGRHDP AVTPRAIPIV EAMTALVLAD 360
  361 ALLIQKARDF SRSVVH

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.01
Match: 1fw8A
Description: Phosphoglycerate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
chorismate synthase activity 5.15976990017342 bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates 4.26558071446785 bayes_pls_golite062009
catalytic activity 1.94308403509017 bayes_pls_golite062009
carbon-oxygen lyase activity 1.59965915025616 bayes_pls_golite062009
lyase activity 1.53765291169529 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle