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View Structure Prediction Details

Protein: CDC14
Organism: Saccharomyces cerevisiae
Length: 551 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC14.

Description E-value Query
Range
Subject
Range
gi|870756 - gi|870756|dbj|BAA09533.1| phosphoprotein phosphatase [Saccharomyces cerevisiae]
0.0 [1..551] [1..551]
gi|7413671 - gi|7413671|emb|CAB85704.1| protein phosphatase [Candida albicans]
0.0 [11..547] [11..539]
gi|55665697, gi|... - gi|55665697|emb|CAH70069.1| CDC14 cell division cycle 14 homolog A (S. cerevisiae) [Homo sapiens], g...
0.0 [12..538] [13..526]
FLP1_SCHPO - Tyrosine-protein phosphatase CDC14 homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
clp1 - Cdc14-related protein phosphatase Clp1 /Flp1
0.0 [7..548] [8..495]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRSVYLDNT IEFLRGRVYL GAYDYTPEDT DELVFFTVED AIFYNSFHLD FGPMNIGHLY  60
   61 RFAVIFHEIL NDPENANKAV VFYSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 7.30669036331612 bayes_pls_golite062009
phosphatase activity 6.6585143972081 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.44546424348532 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.70473199778334 bayes_pls_golite062009
protein tyrosine phosphatase activity 5.3097342170423 bayes_pls_golite062009
alpha-actinin binding 3.03868073080583 bayes_pls_golite062009
actin binding 2.96334024905854 bayes_pls_golite062009
transmembrane receptor protein phosphatase activity 2.94635032478625 bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity 2.94635032478625 bayes_pls_golite062009
cytoskeletal protein binding 2.93073637718155 bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity 2.77531895423367 bayes_pls_golite062009
protein serine/threonine phosphatase activity 2.49496709551693 bayes_pls_golite062009
protein binding 2.12487185456363 bayes_pls_golite062009
binding 2.06015698112379 bayes_pls_golite062009
hydrolase activity 1.9069800114411 bayes_pls_golite062009
nucleic acid binding 1.24416639415232 bayes_pls_golite062009
DNA binding 1.19665037078743 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 1.1200449509328 bayes_pls_golite062009
catalytic activity 1.06283028154109 bayes_pls_golite062009
lipid phosphatase activity 1.05085928819585 bayes_pls_golite062009
phosphoprotein phosphatase inhibitor activity 0.979874859714334 bayes_pls_golite062009
non-membrane spanning protein tyrosine phosphatase activity 0.724257798127697 bayes_pls_golite062009
transporter activity 0.653544405131346 bayes_pls_golite062009
phosphatase inhibitor activity 0.64132831041331 bayes_pls_golite062009
protein kinase activity 0.569334963316149 bayes_pls_golite062009
transmembrane transporter activity 0.401311298433519 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.386515379888428 bayes_pls_golite062009
kinase activity 0.380629891538418 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.343848090522899 bayes_pls_golite062009
transmembrane receptor activity 0.291525352733402 bayes_pls_golite062009
receptor activity 0.191946218805025 bayes_pls_golite062009
enzyme binding 0.150910330021054 bayes_pls_golite062009
kinase binding 0.141802531311128 bayes_pls_golite062009
substrate-specific transporter activity 0.09373220143933 bayes_pls_golite062009
protein kinase binding 0.062562314598915 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [86-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASTRQRANAA CMLCCYMILV QAWTPHQVLQ PLAQVDPPFM PFRDAGYSNA DFEITIQDVV  60
   61 YGVWRAKEKG LIDLHSFNLE SYEKYEHVEF GDFNVLTPDF IAFASPQEDH PKGYLATKSS 120
  121 HLNQPFKSVL NFFANNNVQL VVRLNSHLYN KKHFEDIGIQ HLDLIFEDGT CPDLSIVKNF 180
  181 VGAAETIIKR GGKIAVHCKA GLGRTGCLIG AHLIYTYGFT ANECIGFLRF IRPGMVVGPQ 240
  241 QHWLYLHQND FREWKYTTRI SLKPSEAIGG LYPLISLEEY RLQKKKLKDD KRVAQNNIEG 300
  301 ELRDLTMTPP SNGHGALSAR NSSQPSTANN GSNSFKSSAV PQTSPGQPRK GQNGSNTIED 360
  361 INNNRNPTSH ANRKVVIESN NSDDESMQDT NG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.69897
Match: 1larA_
Description: RPTP Lar
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [478-551]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSNHYPKVSR KKNDISSASS SRMEDNEPSA TNINNAADDT ILRQLLPKNR RVTSGRRTTS  60
   61 AAGGIRKISG SIKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle