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View Structure Prediction Details

Protein: UBP6
Organism: Saccharomyces cerevisiae
Length: 499 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBP6.

Description E-value Query
Range
Subject
Range
gi|190406582 - gi|190406582|gb|EDV09849.1| ubiquitin carboxyl-terminal hydrolase 6 [Saccharomyces cerevisiae RM11-1...
gi|207345648 - gi|207345648|gb|EDZ72402.1| YFR010Wp-like protein [Saccharomyces cerevisiae AWRI1631]
UBP6_YEAST - Ubiquitin carboxyl-terminal hydrolase 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
gi|151940772 - gi|151940772|gb|EDN59159.1| ubiquitin-specific protease [Saccharomyces cerevisiae YJM789]
UBP6 - Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubi...
4.0E-90 [1..495] [1..495]
ubp6 - ubiquitin C-terminal hydrolase Ubp6
UBP6_SCHPO - Ubiquitin carboxyl-terminal hydrolase 6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ub...
4.0E-87 [6..499] [2..466]
gi|11993465 - gi|11993465|gb|AAG42751.1|AF302660_1 ubiquitin-specific protease 6 [Arabidopsis thaliana]
5.0E-79 [7..497] [3..478]
UBP14_MOUSE - Ubiquitin carboxyl-terminal hydrolase 14 OS=Mus musculus GN=Usp14 PE=1 SV=3
3.0E-78 [5..499] [3..486]
UBP14_RABIT - Ubiquitin carboxyl-terminal hydrolase 14 OS=Oryctolagus cuniculus GN=USP14 PE=1 SV=3
6.0E-78 [5..499] [3..486]
gi|124126877, gi... - gi|60655635|gb|AAX32381.1| ubiquitin specific protease 14 [synthetic construct], gi|60655633|gb|AAX3...
USP14 - ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
2.0E-77 [5..499] [3..487]
CG5384-PA, FBpp0... - This gene is referred to in FlyBase by the symbol Dmel\CG5384 (CG5384, FBgn0032216). It is a protein...
1.0E-73 [5..494] [3..467]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGETFEFNI RHSGKVYPIT LSTDATSADL KSKAEELTQV PSARQKYMVK GGLSGEESIK  60
   61 IYPLIKPGST VMLLGTPDAN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.39794
Match: 1ud7A_
Description: Ubiquitin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 3.22676362920771 bayes_pls_golite062009
hydrolase activity 2.77871378503369 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.46621820231139 bayes_pls_golite062009
acid-amino acid ligase activity 2.24025972049145 bayes_pls_golite062009
binding 2.19381585790185 bayes_pls_golite062009
protein tag 1.93603588492737 bayes_pls_golite062009
protein binding 1.84908810286528 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 1.54640383227873 bayes_pls_golite062009
SUMO ligase activity 0.58905960362002 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.536856055841234 bayes_pls_golite062009
kinase activity 0.506057697290914 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.410719674374641 bayes_pls_golite062009
nucleic acid binding 0.383121378043805 bayes_pls_golite062009
protein kinase activity 0.325253662829604 bayes_pls_golite062009
transferase activity 0.236208643697075 bayes_pls_golite062009
DNA binding 0.0840213088061073 bayes_pls_golite062009
transcription regulator activity 0.0485636215870291 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [81-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LISKPAKKNN FIEDLAPEQQ VQQFAQLPVG FKNMGNTCYL NATLQALYRV NDLRDMILNY  60
   61 NPSQGVSNSG AQDEE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 14.031517
Match: PF00442
Description: No description for PF00442 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
peptidase activity 7.38847948226412 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 7.21002260103248 bayes_pls_golite062009
endopeptidase activity 6.57191549077589 bayes_pls_golite062009
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
hydrolase activity 4.82615927403291 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.3276268995308 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.854677025220204 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.495951820083869 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.168761518285256 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [156-425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IHKQIVIEMK RCFENLQNKS FKSVLPIVLL NTLRKCYPQF AERDSQGGFY KQQDAEELFT  60
   61 QLFHSMSIVF GDKFSEDFRI QFKTTIKDTA NDNDITVKEN ESDSKLQCHI SGTTNFMRNG 120
  121 LLEGLNEKIE KRSDLTGANS IYSVEKKISR LPKFLTVQYV RFFWKRSTNK KSKILRKVVF 180
  181 PFQLDVADML TPEYAAEKVK VRDELRKVEK EKNEKEREIK RRKFDPSSSE NVMTPREQYE 240
  241 TQVALNESEK DQWLEEYKKH FPPNLEKGEN 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [426-499]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSCVYNLIGV ITHQGANSES GHYQAFIRDE LDENKWYKFN DDKVSVVEKE KIESLAGGGE  60
   61 SDSALILMYK GFGL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 29.619789
Match: PF00443
Description: Ubiquitin carboxyl-terminal hydrolase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle