YRC Public Data Repository - Protein Structure Prediction

Protein:	MSH4
Organism:	Saccharomyces cerevisiae
Length:	878 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSH4.

Description	E-value	Query Range	Subject Range
gi\|125617373, gi... - gi\|75829241\|ref\|ZP_00758551.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae MO10],... gi\|229353916, gi... - gi\|229508991\|ref\|ZP_04398479.1\| DNA mismatch repair protein MutS [Vibrio cholerae B33], gi\|229353916... MUTS_VIBCH - DNA mismatch repair protein mutS OS=Vibrio cholerae GN=mutS PE=3 SV=1 MUTS_VIBCH - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N1... gi\|75815683 - gi\|75815683\|ref\|ZP_00746180.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae V52] MUTS_VIBCM - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain M66-2) GN=mutS PE=3 SV=1 gi\|229507146, gi... - gi\|229507146\|ref\|ZP_04396652.1\| DNA mismatch repair protein MutS [Vibrio cholerae BX 330286], gi\|229... gi\|229344348, gi... - gi\|229519659\|ref\|ZP_04409102.1\| DNA mismatch repair protein MutS [Vibrio cholerae RC9], gi\|229344348... MUTS_VIBC3 - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa... gi\|153223827, gi... - gi\|153223827\|ref\|ZP_01954082.1\| DNA mismatch repair protein MutS [Vibrio cholerae MAK 757], gi\|12411... gi\|126510344, gi... - gi\|153819112\|ref\|ZP_01971779.1\| DNA mismatch repair protein MutS [Vibrio cholerae NCTC 8457], gi\|126...	0.0	[8..874]	[44..860]
MSH4 - Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes ... MSH4_YEAST - MutS protein homolog 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH4 PE=1 SV=2	0.0	[1..878]	[1..878]
MUTS_AZOVI - DNA mismatch repair protein MutS OS=Azotobacter vinelandii GN=mutS PE=3 SV=1	0.0	[8..870]	[36..849]
MUTS_PSEAE - DNA mismatch repair protein mutS OS=Pseudomonas aeruginosa GN=mutS PE=3 SV=1 MUTS_PSEAE - DNA mismatch repair protein MutS OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 ... gi\|126168466, gi... - gi\|254236535\|ref\|ZP_04929858.1\| DNA mismatch repair protein MutS [Pseudomonas aeruginosa C3719], gi\|...	0.0	[8..870]	[36..849]
gi\|7229490\|gb\|AA... - mismatch repair protein MutS [Pseudomonas aeruginosa] gi\|7229490 - gi\|7229490\|gb\|AAF42850.1\| mismatch repair protein MutS [Pseudomonas aeruginosa]	0.0	[8..870]	[36..850]
MUTS_HAEIN - DNA mismatch repair protein mutS OS=Haemophilus influenzae GN=mutS PE=3 SV=1 MUTS_HAEIN - DNA mismatch repair protein MutS OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / R...	0.0	[8..875]	[39..859]
gi\|22124746, gi\|... - gi\|22124746\|ref\|NP_668169.1\| DNA mismatch repair protein [Yersinia pestis KIM], gi\|21957565\|gb\|AAM84... gi\|218930372, gi... - gi\|218930372\|ref\|YP_002348247.1\| DNA mismatch repair protein MutS [Yersinia pestis CO92], gi\|1612350... gi\|45435046, gi\|... - gi\|45440190\|ref\|NP_991729.1\| DNA mismatch repair protein [Yersinia pestis biovar Microtus str. 91001... MUTS_YERPG - DNA mismatch repair protein MutS OS=Yersinia pestis bv. Antiqua (strain Angola) GN=mutS PE=3 SV=1 gi\|167469363 - gi\|167469363\|ref\|ZP_02334067.1\| DNA mismatch repair protein MutS [Yersinia pestis FV-1] gi\|167423797, gi... - gi\|167423797\|ref\|ZP_02315550.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Mediaevalis... gi\|149289239, gi... - gi\|153997602\|ref\|ZP_02022702.1\| DNA mismatch repair protein MutS [Yersinia pestis CA88-4125], gi\|149... MUTS_YERPP - DNA mismatch repair protein MutS OS=Yersinia pestis (strain Pestoides F) GN=mutS PE=3 SV=1 gi\|166010151, gi... - gi\|166010151\|ref\|ZP_02231049.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Antiqua str... MUTS_YERPE - DNA mismatch repair protein MutS OS=Yersinia pestis GN=mutS PE=3 SV=1 gi\|165922488, gi... - gi\|165925876\|ref\|ZP_02221708.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Orientalis ... gi\|229695346, gi... - gi\|229838980\|ref\|ZP_04459139.1\| methyl-directed mismatch repair protein [Yersinia pestis biovar Orie... gi\|167421538, gi... - gi\|167421538\|ref\|ZP_02313291.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Orientalis ... gi\|229687039, gi... - gi\|229899547\|ref\|ZP_04514688.1\| methyl-directed mismatch repair protein [Yersinia pestis biovar Orie... gi\|166205736, gi... - gi\|166212949\|ref\|ZP_02238984.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Antiqua str... gi\|165936708, gi... - gi\|89105881\|ref\|ZP_01178393.1\| COG0249: Mismatch repair ATPase (MutS family) [Yersinia pestis biovar... MUTS_YERPN - DNA mismatch repair protein MutS OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=mutS PE=3 SV=1	0.0	[8..875]	[39..850]
gi\|205324663, gi... - gi\|205324663\|gb\|EDZ12502.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... gi\|167993148, gi... - gi\|205328749\|gb\|EDZ15513.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... gi\|168242649, gi... - gi\|205338197\|gb\|EDZ24961.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... MUTS_SALCH - DNA mismatch repair protein MutS OS=Salmonella choleraesuis (strain SC-B67) GN=mutS PE=3 SV=1 lcl\|NC_016856.1_... - [gene=mutS] [protein=DNA mismatch repair protein] [protein_id=YP_005239020.1] [location=3070516..307... MUTS_SALTY - DNA mismatch repair protein mutS OS=Salmonella typhimurium GN=mutS PE=1 SV=1 MUTS_SALCH - DNA mismatch repair protein mutS OS=Salmonella choleraesuis GN=mutS PE=3 SV=1 MUTS_SALCH - DNA mismatch repair protein mutS OS=Salmonella choleraesuis GN=mutS PE=3 SV=1 MUTS_SALTI - DNA mismatch repair protein MutS OS=Salmonella typhi GN=mutS PE=3 SV=1 MUTS_SALG2 - DNA mismatch repair protein MutS OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=mutS PE=3 ... MUTS_SALTY - DNA mismatch repair protein MutS OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=... gi\|213854165 - gi\|213854165\|ref\|ZP_03382697.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... MUTS_SALTY - DNA mismatch repair protein mutS OS=Salmonella typhimurium GN=mutS PE=1 SV=1 MUTS_SALPB - DNA mismatch repair protein mutS OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutS PE=... MUTS_SALPB - DNA mismatch repair protein MutS OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutS PE=... MUTS_SALTI - DNA mismatch repair protein mutS OS=Salmonella typhi GN=mutS PE=3 SV=1 gi\|168463951, gi... - gi\|195633763\|gb\|EDX52177.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... MUTS_SALHS - DNA mismatch repair protein MutS OS=Salmonella heidelberg (strain SL476) GN=mutS PE=3 SV=1 gi\|29143167, gi\|... - gi\|29143167\|ref\|NP_806509.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... MUTS_SALA4 - DNA mismatch repair protein MutS OS=Salmonella agona (strain SL483) GN=mutS PE=3 SV=1 gi\|16761683 - gi\|16761683\|ref\|NP_457300.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... gi\|197240275, gi... - gi\|197262020\|ref\|ZP_03162094.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enteric...	0.0	[8..873]	[41..852]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESNLSSFI STNYFNLRSA ANSSNSISKP STKKSIRNQK SPTNISSWAL KKKTLQIAET  60
   61 TWENNEKDST HSHYLMTGSM ASRT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1316.9897
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [85-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATSLSRYSTN ASLLGPSIDC VLCCIYEVPR DISTRIGLCI INCNTGQMYL SDFMDSQIYI  60
   61 RVVHKLQIYQ PTEILIPSSS LAPTVSKLAT MIKFNVAETV KIEEGSRKCF NSQDGLAAIT 120
  121 KYLMDDTKKD LKIEEIIDKT FALCAASAAI SYMEEIISKS SRNLNAFRKL RIQFEGTE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1316.9897
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [263-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTMLIDSKTV RGLELVENKL DKNGI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [585-878]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KENNYTIPIF TNNLLIRDSR HPLLEKVLKN FVPNTISSTK HSSSLQIITG CNMSGKSVYL  60
   61 KQVALICIMA QMGSGIPALY GSFPVFKRLH ARVCNDSMEL TSSNFGFEMK EMAYFLDDIN 120
  121 TETLLILDEL GRGSSIADGF CVSLAVTEHL LRTEATVFLS THFQDIPKIM SKKPAVSHLH 180
  181 MDAVLLNDNS VKMNYQLTQK SVAIENSGIR VVKKIFNPDI IAEAYNIHSL LKIAKARTEN 240
  241 EDSNGVVDQK TINQMKRIHN LVAILKECAG NEKEPLTLGK LKEINSDFIE NFEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1316.9897
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [288-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLWKFLDTTS TKMGQRSLRN SILQPLTDRG SIEMRLEALE ELKANDDLLQ KLRLEMKSLP  60
   61 DLDKLFSRLL CINHSAIKPD QRINYVLLLK ETLQSVKSLK DALNDQLIQS RLISETKKIF 120
  121 NNDAIMEIEK LINSCINEDC VWASSAIQLL NQRSYAVKSD SNGLLDVSRQ IY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [537-584]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVMEEILLLS EETVDELLDK IATHISELFM IAEAVAILDL VCSFTYNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1316.9897
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [460-536]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEVKEEFFRE VEDLTAKNKI NLDHNYDSAR GFYLRIKRQE FTDDVATLPD VFISRTIKKN  60
   61 YIECTTLNII KKNARLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1316.9897
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits