YRC Public Data Repository - Protein Structure Prediction

Protein:	YER134C
Organism:	Saccharomyces cerevisiae
Length:	178 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YER134C.

Description	E-value	Query Range	Subject Range
YER134C - Putative protein of unknown function; non-essential gene gi\|151944854 - gi\|151944854\|gb\|EDN63113.1\| conserved protein [Saccharomyces cerevisiae YJM789] gi\|190405695 - gi\|190405695\|gb\|EDV08962.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] gi\|207345840 - gi\|207345840\|gb\|EDZ72531.1\| YER134Cp-like protein [Saccharomyces cerevisiae AWRI1631] MGDP1_YEAST - Putative magnesium-dependent phosphatase YER134C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...	3.0E-51	[1..178]	[1..178]
SPBP8B7.31 - acid phosphatase MGDP1_SCHPO - Putative magnesium-dependent phosphatase P8B7.31 OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...	2.0E-42	[4..172]	[7..168]
MGDP1_MOUSE - Magnesium-dependent phosphatase 1 OS=Mus musculus GN=Mdp1 PE=1 SV=1	1.0E-41	[1..162]	[1..145]
gi\|157875145 - gi\|157875145\|ref\|XP_001685977.1\| hypothetical protein [Leishmania major strain Friedlin] gi\|68129050, gi\|... - gi\|68129050\|emb\|CAJ06578.1\| hypothetical protein, conserved [Leishmania major], gi\|11071680\|emb\|CAC1...	2.0E-38	[2..168]	[14..187]
EG11871 - phosphoglycolate phosphatase / Phosphoglycolate phosphatase; in dam operon; involved in degradation ... gi\|194421583, gi... - gi\|83585104\|ref\|ZP_00923756.1\| COG0546: Predicted phosphatases [Escherichia coli 101-1], gi\|19443949... gi\|75211751, gi\|... - gi\|75211751\|ref\|ZP_00711815.1\| COG0546: Predicted phosphatases [Escherichia coli B171], gi\|194426923... gi\|238902476, gi... - gi\|238902476\|ref\|YP_002928272.1\| phosphoglycolate phosphatase [Escherichia coli BW2952], gi\|23886204... gi\|191167879, gi... - gi\|75228961\|ref\|ZP_00715553.1\| COG0546: Predicted phosphatases [Escherichia coli B7A], gi\|191167879\|... gi\|251786638, gi... - gi\|251786638\|ref\|YP_003000942.1\| hypothetical protein B21_03189 [Escherichia coli BL21], gi\|24237891... gi\|193061794, gi... - gi\|75260326\|ref\|ZP_00731594.1\| COG0546: Predicted phosphatases [Escherichia coli E22], gi\|193061794\|... gi\|253771788, gi... - gi\|254290063\|ref\|YP_003055811.1\| phosphoglycolate phosphatase [Escherichia coli BL21(DE3)], gi\|25397... gi\|89110625, gi\|... - gi\|89110625\|ref\|AP_004405.1\| phosphoglycolate phosphatase [Escherichia coli str. K-12 substr. W3110]... gi\|253975214, gi... - gi\|254163313\|ref\|YP_003046421.1\| phosphoglycolate phosphatase [Escherichia coli B str. REL606], gi\|2... GPH_ECOLI - Phosphoglycolate phosphatase (EC 3.1.3.18) (PGPase) (PGP) - Escherichia coli gi\|170082902, gi... - gi\|170082902\|ref\|YP_001732222.1\| phosphoglycolate phosphatase [Escherichia coli str. K-12 substr. DH... EG11871 - phosphoglycolate phosphatase / Phosphoglycolate phosphatase; in dam operon; involved in degradation ...	1.0E-33	[23..167]	[75..219]
gi\|75516147, gi\|... - gi\|75516147\|ref\|ZP_00738265.1\| COG0546: Predicted phosphatases [Escherichia coli 53638], gi\|18849334... gi\|157162861, gi... - gi\|75197316\|ref\|ZP_00707386.1\| COG0546: Predicted phosphatases [Escherichia coli HS], gi\|157162861\|r... gi\|226839055, gi... - gi\|254038549\|ref\|ZP_04872605.1\| phosphoglycolate phosphatase [Escherichia sp. 1_1_43], gi\|226839055\|... gi\|209756690, gi... - pir\|\|C91157 phosphoglycolate phosphatase [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|254795299, gi... - gi\|254795299\|ref\|YP_003080136.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. TW14359... gi\|209397865, gi... - gi\|209397865\|ref\|YP_002272819.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4115]... gi\|15803888, gi\|... - gi\|15803888\|ref\|NP_289924.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 EDL933], gi\|1251... gi\|208741353, gi... - gi\|208821230\|ref\|ZP_03261550.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4042],... gi\|217325172, gi... - gi\|217325172\|ref\|ZP_03441256.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. TW14588]... gi\|124500814, gi... - gi\|124528159\|ref\|ZP_01699492.1\| phosphoglycolate phosphatase [Escherichia coli B], gi\|124500814\|gb\|E... gi\|168779465, gi... - gi\|189002264\|gb\|EDU71250.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4076], gi\|... gi\|168772727, gi... - gi\|187771456\|gb\|EDU35300.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4196], gi\|... gi\|168797152, gi... - gi\|189380127\|gb\|EDU98543.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC508], gi\|1... gi\|168785186, gi... - gi\|189374428\|gb\|EDU92844.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC869], gi\|1... gi\|195934873 - gi\|195934873\|ref\|ZP_03080255.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4024] GPH_ECO57 - Phosphoglycolate phosphatase OS=Escherichia coli O157:H7 GN=gph PE=3 SV=1 gi\|15833481, gi\|... - gi\|15833481\|ref\|NP_312254.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|170018379, gi... - gi\|170018379\|ref\|YP_001723333.1\| phosphoglycolate phosphatase [Escherichia coli ATCC 8739], gi\|16975... gi\|208814054, gi... - gi\|208814054\|ref\|ZP_03255383.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4045],... gi\|208727293, gi... - gi\|208807492\|ref\|ZP_03249829.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4206],... gi\|189359166, gi... - gi\|189359166\|gb\|EDU77585.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4401], gi\|... gi\|168751804, gi... - gi\|188014205\|gb\|EDU52327.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4113], gi\|... gi\|189364353, gi... - gi\|189364353\|gb\|EDU82772.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4486], gi\|... gi\|168759406, gi... - gi\|189369601\|gb\|EDU88017.1\| phosphoglycolate phosphatase [Escherichia coli O157:H7 str. EC4501], gi\|...	1.0E-33	[23..167]	[75..219]
gi\|84324223, gi\|... - gi\|84324223\|ref\|ZP_00972286.1\| COG0546: Predicted phosphatases [Pseudomonas aeruginosa 2192], gi\|254... GPH1_PSEAE - Phosphoglycolate phosphatase 1 OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / ... GPH1_PSEAE - Phosphoglycolate phosphatase 1 OS=Pseudomonas aeruginosa GN=gph1 PE=3 SV=1	2.0E-32	[2..165]	[10..207]
GPH_SALTY - Phosphoglycolate phosphatase OS=Salmonella typhimurium GN=gph PE=3 SV=1 GPH_SALTY - Phosphoglycolate phosphatase OS=Salmonella typhimurium GN=gph PE=3 SV=1 gi\|167994587, gi... - gi\|205327601\|gb\|EDZ14365.1\| phosphoglycolate phosphatase [Salmonella enterica subsp. enterica serova... lcl\|NC_016856.1_... - [gene=gph] [protein=phosphoglycolate phosphatase] [protein_id=YP_005239680.1] [location=complement(3... GPH_SALTY - Phosphoglycolate phosphatase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=gph ...	3.0E-32	[23..167]	[75..219]
GPH_SALTI - Phosphoglycolate phosphatase OS=Salmonella typhi GN=gph PE=3 SV=1 GPH_SALTI - Phosphoglycolate phosphatase OS=Salmonella typhi GN=gph PE=3 SV=1 gi\|16762805 - gi\|16762805\|ref\|NP_458422.1\| phosphoglycolate phosphatase [Salmonella enterica subsp. enterica serov...	7.0E-32	[23..166]	[75..218]
GPH_KLEAE - Phosphoglycolate phosphatase OS=Klebsiella aerogenes GN=gph PE=3 SV=1 GPH_ENTAE - Phosphoglycolate phosphatase OS=Enterobacter aerogenes GN=gph PE=3 SV=1	5.0E-30	[23..174]	[75..229]

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Predicted Domain #1

Region A:
Residues: [1-20]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGYPDVAAF DLDYTIWPCY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [55-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIPRILGDLK DNGVKLMTAS RTWAPEIAQE ILKIFKVKYA G

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [110-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GERSKIGHLR DGLKDLYNTS DLKSKKICLF DDESRNKEVE KYGVKFVYVR DPENGPSWKL  60
   61 YQDYLSGKV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.0
Match:	1l7mA_
Description:	Phosphoserine phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	0.877696725573375	bayes_pls_golite062009
catalytic activity	0.786540433906087	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [21-54]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CDTHLHGPFK PVKSSNGEVL TIICRDGYEL TIYK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [96-109]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVTPLANLFD EFQW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.0
Match:	1l7mA_
Description:	Phosphoserine phosphatase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: