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View Structure Prediction Details

Protein: ICL1
Organism: Saccharomyces cerevisiae
Length: 557 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ICL1.

Description E-value Query
Range		 Subject
Range
ACEA_GOSHI - Isocitrate lyase OS=Gossypium hirsutum PE=2 SV=1
 0.0 [1..553] [1..554]
gi|12005499 - gi|12005499|gb|AAG44479.1|AF243525_1 isocitrate lyase [Ipomoea batatas]
 0.0 [1..553] [1..554]
ACEA_CUCMA - Isocitrate lyase OS=Cucurbita maxima PE=2 SV=1
gi|1695645 - gi|1695645|dbj|BAA11320.1| Isocitrate Lyase [Cucurbita cv. Kurokawa Amakuri]
 0.0 [1..553] [1..554]
ACEA_CYBJA - Isocitrate lyase OS=Cyberlindnera jadinii GN=ICL1 PE=3 SV=1
 0.0 [7..556] [3..549]
gi|68210 - pir||WZCSI isocitrate lyase (EC 4.1.3.1) - castor bean
ACEA_RICCO - Isocitrate lyase OS=Ricinus communis PE=2 SV=1
 0.0 [1..553] [1..554]
ACEA_BRANA - Isocitrate lyase OS=Brassica napus PE=2 SV=1
 0.0 [1..553] [1..554]
ACEA_CANAX - Isocitrate lyase OS=Candida albicans GN=ICL1 PE=3 SV=1
 0.0 [7..556] [3..549]
ACEA_SOLLC - Isocitrate lyase OS=Solanum lycopersicum PE=2 SV=1
 0.0 [3..553] [2..554]
gi|190405628 - gi|190405628|gb|EDV08895.1| isocitrate lyase [Saccharomyces cerevisiae RM11-1a]
ICL1 - Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reactio...
ACEA_YEAST - Isocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICL1 PE=1 SV=1
gi|151944780 - gi|151944780|gb|EDN63039.1| isocitrate lyase [Saccharomyces cerevisiae YJM789]
 0.0 [1..557] [1..557]
ACEA_CUCSA - Isocitrate lyase OS=Cucumis sativus PE=3 SV=1
 0.0 [1..553] [1..554]

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Predicted Domain #1
Region A:
Residues: [1-270] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIPVGNTKN DFAALQAKLD ADAAEIEKWW SDSRWSKTKR NYSARDIAVR RGTFPPIEYP  60
   61 SSVMARKLFK VLEKHHNEGT VSKTFGALDP VQISQMAKYL DTIYISGWQC SSTASTSNEP 120
  121 GPDLADYPMD TVPNKVEHLF KAQLFHDRKQ LEARSKAKSQ EELDEMGAPI DYLTPIVADA 180
  181 DAGHGGLTAV FKLTKMFIER GAAGIHMEDQ TSTNKKCGHM AGRCVIPVQE HVNRLVTIRM 240
  241 CADIMHSDLI VVARTDSEAA TLISSTIDTR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [385-557] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRGGTQCSIM RARAFAPYAD LVWMESNYPD FQQAKEFAEG VKEKFPDQWL AYNLSPSFNW  60
   61 PKAMSVDEQH TFIQRLGDLG YIWQFITLAG LHTNALAVHN FSRDFAKDGM KAYAQNVQQR 120
  121 EMDDGVDVLK HQKWSGAEYI DGLLKLAQGG VSATAAMGTG VTEDQFKENG VKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1dquA_
Description: Isocitrate lyase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
isocitrate lyase activity 4.96824258511407 bayes_pls_golite062009
methylisocitrate lyase activity 4.21728284668468 bayes_pls_golite062009
catalytic activity 2.59838799615646 bayes_pls_golite062009
transferase activity 1.07154136609184 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.366715189574293 bayes_pls_golite062009
lyase activity 0.0456521871650777 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [271-384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHYFIVGATN PNIEPFAEVL NDAIMSGASG QELADIEQKW CRDAGLKLFH EAVIDEIERS  60
   61 ALSNKQELIK KFTSKVGPLT ETSHREAKKL AKEILGHEIF FDWELPRVRE GLYR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1dquA_
Description: Isocitrate lyase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle