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View Structure Prediction Details

Protein: EUG1
Organism: Saccharomyces cerevisiae
Length: 517 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EUG1.

Description E-value Query
Range
Subject
Range
EUG1 - Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p...
EUG1_YEAST - Protein disulfide-isomerase EUG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EUG1 PE...
0.0 [1..517] [1..517]
gi|5326749 - gi|5326749|gb|AAD42032.1|AF075246_1 protein disulfide isomerase precursor [Kluyveromyces marxianus]
0.0 [1..507] [1..500]
PDI_ASPNG - Protein disulfide-isomerase OS=Aspergillus niger GN=pdiA PE=2 SV=1
0.0 [6..517] [2..515]
PDIA1_RABIT - Protein disulfide-isomerase OS=Oryctolagus cuniculus GN=P4HB PE=2 SV=1
0.0 [8..517] [1..509]
gi|5650705, gi|4... - gi|5650705|emb|CAB51612.1| protein disulfide isomerase [Kluyveromyces lactis], gi|49641377|emb|CAH01...
gi|50304577, gi|... - gi|50304577|ref|XP_452244.1| unnamed protein product [Kluyveromyces lactis], gi|49641377|emb|CAH0109...
0.0 [13..498] [11..491]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..507] [1..505]
PDIA1_MOUSE, PDI... - (P09103) Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4-hydroxylase beta subunit...
0.0 [8..517] [1..509]
SPAC1F5.02 - protein disulfide isomerase
PDI1_SCHPO - Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
0.0 [17..517] [6..492]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVTTRFISA IVSFCLFASF TLAENSARAT PGSDLLVLTE KKFKSFIESH PLVLVEFFAP  60
   61 WCLHSQILRP HLEEAASILK EHNVPVVQID CEANSMVCLQ QTINTYPTLK IFKNGRIFDG 120
  121 QVYRGVKITD EITQYMIQLY EASVIY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 140.29073
Match: 1mek__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [147-255]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNSEDEIQPY LENATLPVVI NRGLTGLNET YQEVALDLAE DYVFLSLLDS EDKSLSIHLP  60
   61 NTTEPILFDG NVDSLVGNSV ALTQWLKVVI LPYFTDIEPD LFPKYISSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.39794
Match: 1bjx__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [256-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPLAYFFYTS EEELEDYTDL FTQLGKENRG QINFIALNST MFPHHVRFLN MREQFPLFAI  60
   61 HNMINNLKYG LPQLP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.722 0.979 protein disulfide isomerase activity c.47.1 Thioredoxin-like

Predicted Domain #4
Region A:
Residues: [331-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEYAKLEKP QPLDRDMIVQ LVKDYREGTA KPIVKSEEIP KEQKSNVYKI VGKTHDDIVH  60
   61 DDDKDVLVKY YATWCIHSKR FAPIYEEIAN VLASDESVRD KILIAEVDSG ANDILSFPVT 120
  121 GYPTIALYPA GNNSKPIIFN KIRNLEDVFE FIKESGTHHI DGQAIYDKLH QAKDSEVSTE 180
  181 DTVHDEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.70927
Match: 1dbyA_
Description: Thioredoxin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle