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View Structure Prediction Details

Protein: EMI2
Organism: Saccharomyces cerevisiae
Length: 500 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMI2.

Description E-value Query
Range
Subject
Range
EMI2 - Non-essential protein of unknown function required for transcriptional induction of the early meioti...
EMI2_YEAST - Putative glucokinase-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EMI2 PE=1 SV=1
0.0 [1..500] [1..500]
gi|6754206, gi|1... - gi|6754206|ref|NP_034568.1| hexokinase 1 [Mus musculus], gi|1850140|gb|AAB57759.1| hexokinase [Mus m...
0.0 [10..499] [489..934]
HXK1_RAT - Hexokinase-1 OS=Rattus norvegicus GN=Hk1 PE=1 SV=4
0.0 [10..499] [462..907]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [10..499] [462..907]
gi|7245424 - gi|7245424|pdb|1CZA|N Chain N, Mutant Monomer Of Recombinant Human Hexokinase Type I Complexed With ...
0.0 [10..499] [462..907]

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Predicted Domain #1
Region A:
Residues: [1-22]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFENLHKVN AEALEDAVVE IC

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [332-412]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GELLRNILVD LHARGLILGQ YRNYDQLPHR LKTPFQLCSE VLSRIEIDDS TNLRETELSF  60
   61 LQSLRLPTTF EERKAIQNLV R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 824.457575
Match: 1ig8A_
Description: Hexokinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
kinase activity 2.81480196738665 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.66634930184926 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.47806699612578 bayes_pls_golite062009
structural molecule activity 2.37892721989886 bayes_pls_golite062009
carbohydrate kinase activity 2.33338276303563 bayes_pls_golite062009
binding 2.11855816699924 bayes_pls_golite062009
transcription regulator activity 2.09111975841662 bayes_pls_golite062009
protein binding 2.00711904074672 bayes_pls_golite062009
nucleic acid binding 1.84294882554466 bayes_pls_golite062009
hexokinase activity 1.70516840340504 bayes_pls_golite062009
DNA binding 1.70014394990425 bayes_pls_golite062009
cytoskeletal protein binding 1.69431775343358 bayes_pls_golite062009
structural constituent of cytoskeleton 1.58791290104307 bayes_pls_golite062009
glucose binding 1.58717365638543 bayes_pls_golite062009
transferase activity 1.58048472128722 bayes_pls_golite062009
transcription activator activity 1.35676801272576 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.30214785132007 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.30181101672725 bayes_pls_golite062009
pyrophosphatase activity 1.27871475799533 bayes_pls_golite062009
myosin binding 1.26046360733002 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.18894708772738 bayes_pls_golite062009
transcription factor activity 1.06678984888387 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.908385694796738 bayes_pls_golite062009
mannokinase activity 0.766256764215041 bayes_pls_golite062009
actin binding 0.742062735414161 bayes_pls_golite062009
protein kinase activity 0.659672620542945 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.574998559133169 bayes_pls_golite062009
hydrolase activity 0.474893704700898 bayes_pls_golite062009
glucokinase activity 0.47468456642723 bayes_pls_golite062009
sugar binding 0.44352406324938 bayes_pls_golite062009
adenyl nucleotide binding 0.426216374317549 bayes_pls_golite062009
ATP binding 0.39408967688855 bayes_pls_golite062009
adenyl ribonucleotide binding 0.358452809509562 bayes_pls_golite062009
ATPase activity 0.338933039062396 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
monosaccharide binding 0.20435276425198 bayes_pls_golite062009
purine nucleotide binding 0.173637392484485 bayes_pls_golite062009
nucleotide binding 0.168207023557983 bayes_pls_golite062009
ribonucleotide binding 0.104339549630743 bayes_pls_golite062009
purine ribonucleotide binding 0.101742118226005 bayes_pls_golite062009
chromatin binding 0.0489277194984092 bayes_pls_golite062009
unfolded protein binding 0.0304569608189402 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [23-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLQVDAAKL DELTAYFIEC MEKGLNNTSV GEEKTVDKGL PMIPTYVTSL PNGTERGVLL  60
   61 AADLGGTHFR VCSVTLNGDG TFDMQQLKSK IPEEYLNDKD VTSEELFSYL GRRTRAFVRK 120
  121 HHPELLKSTG ENIKPLKMGF TFSYPVDQTS LSSGTLIRWT KSFKIEDTVG KDVVRLYQEQ 180
  181 LDIQGLSMIN VVALTNDTVG TFLSHCYTSG SRPSSAGEIS EPVIGCIFGT GTNGCYMEDI 240
  241 ENIKKLPDEL RTRLLHEGKT QMCINIEWGS FDNELKHLSA TKYDIDIDQK FSPNPGYHLF 300
  301 EKRISGMYL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [413-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SITRRSAYLA AVPIAAILIK TNALNKRYHG EVEIGFDGYV IEYYPGFRSM LRHALALSPI  60
   61 GTEGERKIHL RLAKDGSGVG AALCALVA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 824.457575
Match: 1ig8A_
Description: Hexokinase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle