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View Structure Prediction Details

Protein: SPP41
Organism: Saccharomyces cerevisiae
Length: 1435 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPP41.

Description E-value Query
Range
Subject
Range
SPP41_YEAST - Protein SPP41 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPP41 PE=1 SV=2
SPP41 - Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.0 [1..1435] [1..1435]
CE04485 - WBGene00018024 status:Partially_confirmed TR:Q20007 protein_id:AAB52641.1
6.0E-62 [4..1173] [30..1213]
gi|15277229 - gi|15277229|dbj|BAB63322.1| KIAA0170 [Homo sapiens]
6.0E-60 [2..1218] [431..1674]
gi|24649873, gi|... - gi|7301246|gb|AAF56376.1| CG13648-PA [Drosophila melanogaster], gi|24649873|ref|NP_651318.1| tenecti...
6.0E-58 [20..1302] [1129..2410]

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Predicted Domain #1
Region A:
Residues: [1-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYDEDDGEI NFNELVGNLL SSHNQEGQEE GEVQGGEQEG DDFEKIYPTS ENIEPKHPDD  60
   61 SQHMHNSPDQ NIEIPHFVDE EDELVSVVAN AVQNIDDEQA KPENHLENGS EHVTSDTADD 120
  121 NHEKEQQQEW AHILQQEILK SDGEPLRENT ERRVSTSQHH PSQRTDDALD QDDENLRMAI 180
  181 LESLQELNTN EEEEKEPEKH EHAAPNDKLS SKKSSKKKKK DKSKNRESSK DKSSKKSKSS 240
  241 SHSKKHAKDR NKEKQSKPTN NENTLDLSNI LENLIHENDN AAIDTAKQTV DIQDNSHTDN 300
  301 TNNEDVEAQA LVEATLKAFE NELLSSAPTE EPSQEQSIGP VSSRKAVEPP RKPTADDIPL 360
  361 AMLQAFKPKK RPPQEKKKTK SKTSKAASTA NKSPASESTS KKKKKKKTVK ESNKSQEAYE 420
  421 DDEFSRILAD MVNQVVNTSL KETSTHTATQ DNKLESESDF TSPVQSQYTT EDASTANDDS 480
  481 LDLNQIMQNA MAMVFQNQND DEFDENIVED FNRGLGDLSV SDLLPHDNLS RMEKKSVPKS 540
  541 SSKSEKKTAI SRRASKKASR DASSVELTEV PSKPKKPSKT EVSLEKKLRK KYVSIANEAA 600
  601 SVARKKRWAK NKELKEKEK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [620-1210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LERQTAREER RHKKKLEKQR LAEEQEELKK IVERGPPYPP DLRLTKSGKP KKPYRRWTPE  60
   61 ELLKRSQEAE KPRKVKKERK KKEKKMKVPS SALKKIPLFN FVKGNVQPSA RHRLNDIEGS 120
  121 LSTIGLHKSP DGVRRILSRP KSEDHEWPLS DSSASQNYDA HLKTVVHKEK IPFHPPWTIP 180
  181 SQPPFALPVA RRKKIPNIKK YRKRTNNSFR VSKEGTASTR NRILPAILLP IINTLKAAAK 240
  241 SQTAAGATPE EARKRLATII QHAKSTVIRA ALQARKNSMQ AAHSKGTTTE LATTASRMKN 300
  301 PLKMIPIFNT SRVKQQLDKQ LPARSAGTEI SSSESPDKAT PDPHSNSTIA GHTLKGVTTP 360
  361 IKIEDSDANV PPVSIAVSTI EPSQDKLELT KRAESVEPVE NNVETAKETQ SVQEIKENVG 420
  421 TKASEEVTLT EDKTNGDPKN EKRILIESPV EKTDKKKPGE KIATDLNEDA SLSDKKDGDE 480
  481 KSTLHSDAAQ LTGNEPDSVN TTTGKPKLID VSLKPLNEAK PKIPIIFPLK RPQIKPEVSV 540
  541 INLVQNLVNT KIPEIKNESV DLGSNITDIL SSTITNILPE ITATDVKNYQ Y

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [1211-1262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDENVKYLKK TPRQVLNLDG LVPPSGRCIT KAKRVRRIKK LSADATTAPE AD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.330 0.907 negative regulation of transcription from RNA polymerase II promoter a.22.1 Histone-fold

Predicted Domain #4
Region A:
Residues: [1263-1435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKANSESITY TFDIPSPEEV QSKRSVVLKF AKARLTEAEL SCLKKEINNV RKRRWREMNS  60
   61 TKNWEYDVKS RLKKRANAFF GEGESETKSK WIEERFQEKV SQEKYKDRLE TTETQANNTK 120
  121 IVIDDKEILN ILAVNMNNLN KARCIEKDIQ ESFREEKLAS LQPKKKRKKS ILH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [580-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEVSLEKKLR KKYVSIANEA ASVARKKRWA KNKELKEKEK LERQTAREER RHKKKLEKQR  60
   61 LAEEQEELKK IVERGPPYPP DLRLT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [665-875]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSGKPKKPYR RWTPEELLKR SQEAEKPRKV KKERKKKEKK MKVPSSALKK IPLFNFVKGN  60
   61 VQPSARHRLN DIEGSLSTIG LHKSPDGVRR ILSRPKSEDH EWPLSDSSAS QNYDAHLKTV 120
  121 VHKEKIPFHP PWTIPSQPPF ALPVARRKKI PNIKKYRKRT NNSFRVSKEG TASTRNRILP 180
  181 AILLPIINTL KAAAKSQTAA GATPEEARKR L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [876-983]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATIIQHAKST VIRAALQARK NSMQAAHSKG TTTELATTAS RMKNPLKMIP IFNTSRVKQQ  60
   61 LDKQLPARSA GTEISSSESP DKATPDPHSN STIAGHTLKG VTTPIKIE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [984-1201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSDANVPPVS IAVSTIEPSQ DKLELTKRAE SVEPVENNVE TAKETQSVQE IKENVGTKAS  60
   61 EEVTLTEDKT NGDPKNEKRI LIESPVEKTD KKKPGEKIAT DLNEDASLSD KKDGDEKSTL 120
  121 HSDAAQLTGN EPDSVNTTTG KPKLIDVSLK PLNEAKPKIP IIFPLKRPQI KPEVSVINLV 180
  181 QNLVNTKIPE IKNESVDLGS NITDILSSTI TNILPEIT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1202-1435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATDVKNYQYE DENVKYLKKT PRQVLNLDGL VPPSGRCITK AKRVRRIKKL SADATTAPEA  60
   61 DGKANSESIT YTFDIPSPEE VQSKRSVVLK FAKARLTEAE LSCLKKEINN VRKRRWREMN 120
  121 STKNWEYDVK SRLKKRANAF FGEGESETKS KWIEERFQEK VSQEKYKDRL ETTETQANNT 180
  181 KIVIDDKEIL NILAVNMNNL NKARCIEKDI QESFREEKLA SLQPKKKRKK SILH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle