YRC Public Data Repository - Protein Structure Prediction

Protein:	NHX1
Organism:	Saccharomyces cerevisiae
Length:	633 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NHX1.

Description	E-value	Query Range	Subject Range
NHX1 - Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolera... NHX1_YEAST - Endosomal/prevacuolar sodium/hydrogen exchanger OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...	0.0	[1..633]	[1..633]
gi\|8886699 - gi\|8886699\|gb\|AAF80554.1\|AF187723_1 Na+/H+ antiporter [Aedes aegypti]	0.0	[42..571]	[234..749]
SL9A2_RAT - Sodium/hydrogen exchanger 2 OS=Rattus norvegicus GN=Slc9a2 PE=1 SV=1 gi\|205319 - gi\|205319\|gb\|AAA72350.1\| Na/H ion exchanger [Rattus sp.]	0.0	[2..556]	[17..552]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..543]	[28..558]
SL9A2_RABIT - Sodium/hydrogen exchanger 2 OS=Oryctolagus cuniculus GN=SLC9A2 PE=2 SV=1	2.0E-99	[3..556]	[17..551]
gi\|178753 - gi\|178753\|gb\|AAB59460.1\| Na/H antiporter [Homo sapiens]	3.0E-98	[2..543]	[28..558]
SL9A3_DIDVI - Sodium/hydrogen exchanger 3 OS=Didelphis virginiana GN=SLC9A3 PE=1 SV=1	1.0E-97	[29..557]	[29..534]

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Predicted Domain #1

Region A:
Residues: [1-506]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSKVLLNIA FKVLLTTAKR AVDPDDDDEL LPSPDLPGSD DPIAGDPDVD LNPVTEEMFS  60
   61 SWALFIMLLL LISALWSSYY LTQKRIRAVH ETVLSIFYGM VIGLIIRMSP GHYIQDTVTF 120
  121 NSSYFFNVLL PPIILNSGYE LNQVNFFNNM LSILIFAIPG TFISAVVIGI ILYIWTFLGL 180
  181 ESIDISFADA MSVGATLSAT DPVTILSIFN AYKVDPKLYT IIFGESLLND AISIVMFETC 240
  241 QKFHGQPATF SSVFEGAGLF LMTFSVSLLI GVLIGILVAL LLKHTHIRRY PQIESCLILL 300
  301 IAYESYFFSN GCHMSGIVSL LFCGITLKHY AYYNMSRRSQ ITIKYIFQLL ARLSENFIFI 360
  361 YLGLELFTEV ELVYKPLLII VAAISICVAR WCAVFPLSQF VNWIYRVKTI RSMSGITGEN 420
  421 ISVPDEIPYN YQMMTFWAGL RGAVGVALAL GIQGEYKFTL LATVLVVVVL TVIIFGGTTA 480
  481 GMLEVLNIKT GCISEEDTSD DEFDIE

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	140.387216
Match:	PF00999
Description:	Sodium/hydrogen exchanger family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [507-633]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APRAINLLNG SSIQTDLGPY SDNNSPDISI DQFAVSSNKN LPNNISTTGG NTFGGLNETE  60
   61 NTSPNPARSS MDKRNLRDKL GTIFNSDSQW FQNFDEQVLK PVFLDNVSPS LQDSATQSPA 120
  121 DFSSQNH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits