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View Structure Prediction Details

Protein: UBA2
Organism: Saccharomyces cerevisiae
Length: 636 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBA2.

Description E-value Query
Range
Subject
Range
UBA2 - Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugatio...
UBA2_YEAST - Ubiquitin-activating enzyme E1-like OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBA2...
gi|207346354 - gi|207346354|gb|EDZ72875.1| YDR390Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..636] [1..636]
gi|4574149, gi|4... - gi|4574149|gb|AAD23914.1|AF079566_1 ubiquitin-like protein activating enzyme; sentrin activating enz...
0.0 [14..636] [10..640]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [14..636] [10..640]
gi|220954664 - gi|220954664|gb|ACL89875.1| Uba2-PA [synthetic construct]
Uba2-PA - The gene Smt3 activating enzyme 2 is referred to in FlyBase by the symbol Dmel\Uba2 (CG7528, FBgn002...
0.0 [10..633] [8..636]
SAE2_MOUSE - SUMO-activating enzyme subunit 2 OS=Mus musculus GN=Uba2 PE=1 SV=1
0.0 [14..636] [10..638]
UBA2_SCHPO - Ubiquitin-activating enzyme E1-like OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=uba2 P...
fub2 - SUMO E1-like activator enzyme Fub2
0.0 [13..626] [17..628]

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Predicted Domain #1
Region A:
Residues: [1-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRETSLVTI IGEDSYKKLR SSRCLLVGAG GIGSELLKDI ILMEFGEIHI VDLDTIDLSN  60
   61 LNRQFLFRQK DIKQPKSTTA VKAVQHFNNS KLVPYQGNVM DISTFPLHWF EQFDIIFNAL 120
  121 DNLAARRYVN KISQFLSLPL IESGTAGFDG YMQPIIPGKT ECFECTKKET PKTFPVCTIR 180
  181 STPSQPIHCI VWAKNFLFNQ LFASETSGNE DDNNQDWGTD DAEEIKRIKQ ETNELYELQK 240
  241 IIISRDASRI PEILNKLFIQ DINKLLAIEN LWK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 165.69897
Match: 1jw9B_
Description: Molybdenum cofactor biosynthesis protein MoeB
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [274-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRTKPVPLSD SQINTPTKTA QSASNSVGTI QEQISNFINI TQKLMDRYPK EQNHIEF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.694 a.144.1 PABC (PABP) domain
View Download 0.578 a.64.1 Saposin
View Download 0.587 a.144.2 Ribosomal protein L20
View Download 0.548 a.64.1 Saposin
View Download 0.369 g.57.1 Serine proteinase inhibitor lekti
View Download 0.320 a.4.1 Homeodomain-like
View Download 0.305 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.300 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.300 a.65.1 Annexin
View Download 0.265 a.138.1 Multiheme cytochromes
View Download 0.263 a.50.1 Anaphylotoxins (complement system)
View Download 0.252 d.58.1 4Fe-4S ferredoxins
View Download 0.236 a.4.1 Homeodomain-like
View Download 0.233 a.4.5 "Winged helix" DNA-binding domain
View Download 0.232 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.221 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.220 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.213 d.58.17 Metal-binding domain
View Download 0.211 a.16.1 S15/NS1 RNA-binding domain
View Download 0.209 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.209 a.144.1 PABC (PABP) domain
View Download 0.207 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.207 a.144.2 Ribosomal protein L20
View Download 0.206 g.53.1 TAZ domain
View Download 0.201 a.77.1 DEATH domain

Predicted Domain #3
Region A:
Residues: [331-506]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKDDADTLEF VATAANIRSH IFNIPMKSVF DIKQIAGNII PAIATTNAIV AGASSLISLR  60
   61 VLNLLKYAPT TKYTDLNMAF TAKASNLSQN RYLSNPKLAP PNKNCPVCSK VCRGVIKLSS 120
  121 DCLNKMKLSD FVVLIREKYS YPQDISLLDA SNQRLLFDYD FEDLNDRTLS EINLGN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 64.853872
Match: PF02134
Description: Repeat in ubiquitin-activating (UBA) protein

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [507-636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSIILFSDEE GDTMIRKAIE LFLDVDDELP CNTCSLPDVE VPLIKANNSP SKNEEEEKNE  60
   61 KGADVVATTN SHGKDGIVIL DDDEGEITID AEPINGSKKR PVDTEISEAP SNKRTKLVNE 120
  121 PTNSDIVELD 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.457 0.137 protein sumoylation c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.247 0.048 protein sumoylation a.118.8 TPR-like
View Download 0.231 0.014 protein sumoylation d.82.2 Frataxin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle