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View Structure Prediction Details

Protein: CBS2
Organism: Saccharomyces cerevisiae
Length: 389 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CBS2.

Description E-value Query
Range
Subject
Range
CBS2 - Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on...
gi|151942180 - gi|151942180|gb|EDN60536.1| mitochondrial translational activator [Saccharomyces cerevisiae YJM789]
gi|190404848 - gi|190404848|gb|EDV08115.1| cytochrome b translational activator [Saccharomyces cerevisiae RM11-1a]
CBS2_YEAST - Cytochrome B translational activator protein CBS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
2.0E-85 [1..389] [1..389]
PANE_SCHPO - Probable 2-dehydropantoate 2-reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPB...
SPBPB2B2.09c - 2-dehydropantoate 2-reductase
8.0E-67 [8..383] [5..347]
gi|16765893, gi|... - gi|16765893|ref|NP_461508.1| 2-dehydropantoate 2-reductase [Salmonella typhimurium LT2], gi|16421120...
gi|194408243, gi... - gi|194449939|ref|YP_002046635.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica ...
lcl|NC_016856.1_... - [gene=STM14_3153] [protein=2-dehydropantoate 2-reductase] [protein_id=YP_005238680.1] [location=comp...
gi|205337694, gi... - gi|205337694|gb|EDZ24458.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica serov...
gi|205349332, gi... - gi|205349332|gb|EDZ35963.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica serov...
gi|167549395, gi... - gi|205325261|gb|EDZ13100.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica serov...
gi|205329159, gi... - gi|205329159|gb|EDZ15923.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica serov...
5.0E-62 [6..377] [1..304]
gi|29140818, gi|... - gi|29140818|ref|NP_804160.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica sero...
gi|16761485 - gi|16761485|ref|NP_457102.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica sero...
gi|238912691 - gi|238912691|ref|ZP_04656528.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica s...
gi|25366766, gi|... - gi|25366766|pir||AC0828 probable oxidoreductase STY2819 [imported] - Salmonella enterica subsp. ente...
gi|213646361 - gi|213646361|ref|ZP_03376414.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica s...
gi|213584636 - gi|213584636|ref|ZP_03366462.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica s...
gi|213023229 - gi|213023229|ref|ZP_03337676.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica s...
gi|194404283, gi... - gi|194445620|ref|YP_002041836.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica ...
gi|205342009, gi... - gi|205342009|gb|EDZ28773.1| 2-dehydropantoate 2-reductase [Salmonella enterica subsp. enterica serov...
1.0E-61 [6..377] [1..304]
gi|18144446, gi|... - gi|18309768|ref|NP_561702.1| 2-dehydropantoate 2-reductase [Clostridium perfringens str. 13], gi|181...
8.0E-61 [6..380] [1..308]
gi|18977768, gi|... - gi|18977768|ref|NP_579125.1| 2-dehydropantoate 2-reductase [Pyrococcus furiosus DSM 3638], gi|188935...
9.0E-61 [6..378] [1..296]
PANE_LACLA - Putative 2-dehydropantoate 2-reductase OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=LL1323...
PANE_LACLA - Putative 2-dehydropantoate 2-reductase OS=Lactococcus lactis subsp. lactis GN=LL1323 PE=3 SV=1
3.0E-60 [6..382] [1..312]
PANE_PYRAB - Putative 2-dehydropantoate 2-reductase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=apbA PE=3 SV=1
PANE_PYRAB - Putative 2-dehydropantoate 2-reductase OS=Pyrococcus abyssi GN=PYRAB07590 PE=3 SV=1
3.0E-58 [6..378] [1..296]
PANE_STRP3 - Putative 2-dehydropantoate 2-reductase OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / ...
PANE_STRPY - (P65666) Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Ketopantoate reductase) (KPA reducta...
gi|15674885, gi|... - gi|15674885|ref|NP_269059.1| 2-dehydropantoate 2-reductase [Streptococcus pyogenes M1 GAS], gi|13622...
gi|71853254, gi|... - gi|71910472|ref|YP_282022.1| 2-dehydropantoate 2-reductase [Streptococcus pyogenes MGAS5005], gi|718...
PANE_STRPQ - Putative 2-dehydropantoate 2-reductase OS=Streptococcus pyogenes serotype M3 (strain SSI-1) GN=apbA ...
PANE_STRP1 - Putative 2-dehydropantoate 2-reductase OS=Streptococcus pyogenes serotype M1 GN=apbA PE=3 SV=1
PANE_STRP3 - Putative 2-dehydropantoate 2-reductase OS=Streptococcus pyogenes serotype M3 GN=apbA PE=3 SV=1
2.0E-57 [6..379] [1..304]

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Predicted Domain #1
Region A:
Residues: [1-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSIPRVYS LGNSAMTYLL ALRIAQLPSQ PKVPSVVLLL NDQKKLNRFL NNDSKIIVKS  60
   61 SNNNKETYHR QFMASCVPPI LSNGEIAPIE NLIVSDPSSK FITAQLSKYN KSLRPETNIL 120
  121 FLNPSLNLLE HLHRYRWRFD EARPNLFMGF TTPVDVGTIH QEFQLSLKVK GRIQFHIAKI 180
  181 DGFPRMSSTG KSASLSLRGD RQKNEKENNA FYKLFREISR LRSGIGSDLV SFDLHVHGFQ 240
  241 DLFFT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.522879
Match: 1ks9A_
Description: Ketopantoate reductase PanE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 0.799708671807187 bayes_pls_golite062009
structural molecule activity 0.75267483298133 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.653719917678334 bayes_pls_golite062009
oxidoreductase activity 0.34220594024072 bayes_pls_golite062009
nucleic acid binding 0.285880800622433 bayes_pls_golite062009
DNA binding 0.199566885140605 bayes_pls_golite062009
transcription regulator activity 0.0150328330534928 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [246-389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELEKLILESC TEPLLAVYDC VYKKELLKIP GAQDIIKKLI SEQLSIIDRS YPSLNTNPNY  60
   61 SVIFDKERIF SLVMRDLEVN GHKRAKLAQS LNQLNQTNIN ELNGFFVSLG KYKKCNCKWN 120
  121 DILLTLIKGK QFITKQKALD YHYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.522879
Match: 1ks9A_
Description: Ketopantoate reductase PanE
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle