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View Structure Prediction Details

Protein: REF2
Organism: Saccharomyces cerevisiae
Length: 533 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for REF2.

Description E-value Query
Range
Subject
Range
REF2_YEAST - RNA end formation protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=REF2 PE=1 SV...
gi|190404850 - gi|190404850|gb|EDV08117.1| RNA-binding protein [Saccharomyces cerevisiae RM11-1a]
REF2 - RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation,...
0.0 [1..533] [1..533]
gi|6694636 - gi|6694636|gb|AAF25330.1|AF203752_1 Brca1 [Hipposideros commersoni]
0.007 [184..365] [612..813]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.009 [128..373] [542..772]

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Predicted Domain #1
Region A:
Residues: [1-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPVPQLVN ISHALQASTI QQIRLDMVDF NKDCKLSSIQ LARIDKYIDS LQAALNQFTK  60
   61 DNLHIERKEK NVTEADIQLY SGLKSMYLDY LNQLIKLKHE KQHHSTPPIA NDVSLDFFVN 120
  121 QLPKFSPEER KNYIDNLILN KNSHNRLSKM DGLVDAVINL CVLDTSVAEN VRSYMKLLDT 180
  181 LGFQKGSNST GTKANLKKKL ASSKAKIKDS EKEKEKEKDK SKVKMKTKLK PSPLLNNDDK 240
  241 NSSPSPTAST SSMKKLKSGL FNKNEAKSTE SLPTSSKKKL SFSKYLNKDD ADMTKLGTKR 300
  301 SIDVDFKVNP EASTVASNII SSSTSGSSTT TVATPASSEE PLKKKTKISV QDSNVQSILR 360
  361 NGKPKKARIS SIKFLDDSQL IKVYGDDLPN QGLQVSPTQL KKILKPFKEG EPKEIILFED 420
  421 MSIKLKPLDL MFLKNTNSDD YMDISETKGG PIHCETRTPL IYRKN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.0
Match: 1iwpA
Description: Diol dehydratase, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [466-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNHFNPDLNK RPPREPIEFD LNGNTNSTPT IAKAFGKNSL LLRKDRGGLP YKHVPIVKRN  60
   61 KYPPRPVH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.713 d.58.17 Metal-binding domain
View Download 0.661 b.84.1 Single hybrid motif
View Download 0.667 b.84.2 Rudiment single hybrid motif
View Download 0.707 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.650 d.58.17 Metal-binding domain
View Download 0.646 d.9.1 Interleukin 8-like chemokines
View Download 0.616 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.610 b.40.6 MOP-like
View Download 0.608 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.604 g.28.1 Thyroglobulin type-1 domain
View Download 0.603 d.9.2 Description not found.
View Download 0.572 d.9.2 Description not found.
View Download 0.572 d.9.1 Interleukin 8-like chemokines
View Download 0.572 b.84.1 Single hybrid motif
View Download 0.569 g.5.1 Midkine
View Download 0.563 d.9.1 Interleukin 8-like chemokines
View Download 0.562 d.9.2 Description not found.
View Download 0.549 d.93.1 SH2 domain
View Download 0.536 g.41.8 Zn-binding ribosomal proteins
View Download 0.524 b.84.1 Single hybrid motif
View Download 0.522 d.17.1 Cystatin/monellin
View Download 0.507 d.58.49 YajQ-like
View Download 0.500 b.40.6 MOP-like
View Download 0.496 d.9.1 Interleukin 8-like chemokines
View Download 0.471 b.1.2 Fibronectin type III
View Download 0.468 d.58.17 Metal-binding domain
View Download 0.450 d.58.17 Metal-binding domain
View Download 0.448 d.50.1 dsRNA-binding domain-like
View Download 0.414 d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain
View Download 0.370 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.355 b.1.20 Tp47 lipoprotein, middle and C-terminal domains
View Download 0.315 b.1.1 Immunoglobulin
View Download 0.285 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.284 d.19.1 MHC antigen-recognition domain
View Download 0.273 d.237.1 Hypothetical protein YjiA, C-terminal domain
View Download 0.270 d.19.1 MHC antigen-recognition domain
View Download 0.263 d.59.1 Ribosomal protein L30p/L7e
View Download 0.249 d.93.1 SH2 domain
View Download 0.248 d.68.4 YhbY-like
View Download 0.247 d.204.1 Ribosome binding protein Y (YfiA homologue)
View Download 0.233 d.58.1 4Fe-4S ferredoxins
View Download 0.212 b.38.1 Sm-like ribonucleoproteins
View Download 0.211 b.40.2 Bacterial enterotoxins

Predicted Domain #3
Region A:
Residues: [335-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASSEEPLKK KTKISVQDSN VQSILRNGKP KKARISSIKF LDDSQLIKVY GDDLPNQGLQ  60
   61 VSPTQLKKIL KPFKEGEPKE IILFEDMSIK LKPLDLMFLK NTNSDDYMDI SETKGGPIHC 120
  121 ETRTPLIYRK NFNHFNPDLN KRPPREPIEF DLNGNTNSTP TIAKAFGKNS LLLRKDRGGL 180
  181 PYKHVPIVKR NKYPPRPVH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle