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View Structure Prediction Details

Protein: SEC5
Organism: Saccharomyces cerevisiae
Length: 971 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC5.

Description E-value Query
Range
Subject
Range
SEC5_YEAST - Exocyst complex component SEC5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC5 PE=1...
gi|207346648 - gi|207346648|gb|EDZ73086.1| YDR166Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190404880 - gi|190404880|gb|EDV08147.1| exocyst complex component SEC5 [Saccharomyces cerevisiae RM11-1a]
SEC5 - Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p,...
0.0 [1..971] [1..971]
EXOC2 - exocyst complex component 2
0.0 [39..969] [77..918]
EXOC2_MOUSE - Exocyst complex component 2 OS=Mus musculus GN=Exoc2 PE=1 SV=1
0.0 [39..969] [77..918]
EXOC2_RAT - Exocyst complex component 2 OS=Rattus norvegicus GN=Exoc2 PE=1 SV=1
0.0 [39..969] [77..918]
SEC5A_ARATH - Exocyst complex component SEC5A OS=Arabidopsis thaliana GN=SEC5A PE=1 SV=1
6.0E-95 [44..365] [170..487]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRFQIGDEQ LLRFYQLKTI NPTHSWAQDS SKLNNEEATS NELGVETSFD ILKDFKYGNQ  60
   61 ISIDKESRAY LNDESLSYIR DPLNGQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.336 0.905 bipolar cellular bud site selection c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.442 0.905 bipolar cellular bud site selection a.4.5 "Winged helix" DNA-binding domain
View Download 0.432 0.905 bipolar cellular bud site selection c.10.2 L domain-like
View Download 0.498 0.905 bipolar cellular bud site selection a.46.1 Methionine synthase domain
View Download 0.498 0.905 bipolar cellular bud site selection a.46.1 Methionine synthase domain
View Download 0.442 0.905 bipolar cellular bud site selection a.4.5 "Winged helix" DNA-binding domain
View Download 0.432 0.905 bipolar cellular bud site selection c.10.2 L domain-like
View Download 0.336 0.905 bipolar cellular bud site selection c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.310 0.905 bipolar cellular bud site selection c.10.2 L domain-like
View Download 0.310 0.905 bipolar cellular bud site selection c.10.2 L domain-like
View Download 0.292 0.905 bipolar cellular bud site selection a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.277 0.905 bipolar cellular bud site selection c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.245 0.905 bipolar cellular bud site selection a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.205 0.905 bipolar cellular bud site selection a.60.6 DNA polymerase beta, N-terminal domain-like

Predicted Domain #2
Region A:
Residues: [87-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMSKELQHLP NDSMRLNYLV NSKQFNVKAF LRDMHKQDSF NDLNNSLDRL DSDIQDQSIH  60
   61 LKQLVGKNFT KYVKIK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.640 0.087 vesicle docking during exocytosis a.77.1 DEATH domain
View Download 0.535 0.058 vesicle docking during exocytosis a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.537 0.005 vesicle docking during exocytosis a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.640 N/A N/A a.77.1 DEATH domain
View Download 0.583 N/A N/A a.60.11 Hypothetical protein YjbJ
View Download 0.583 N/A N/A a.60.11 Hypothetical protein YjbJ
View Download 0.574 N/A N/A a.64.2 Bacteriocin AS-48
View Download 0.574 N/A N/A a.64.2 Bacteriocin AS-48
View Download 0.537 N/A N/A a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.535 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.531 N/A N/A a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
View Download 0.512 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.504 N/A N/A a.64.1 Saposin
View Download 0.459 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.447 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.439 N/A N/A a.150.1 Anti-sigma factor AsiA
View Download 0.438 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.438 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.436 N/A N/A a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.425 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.415 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.411 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.410 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.410 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.403 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.397 N/A N/A a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.391 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.379 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.378 N/A N/A a.60.2 RuvA domain 2-like
View Download 0.366 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.364 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.359 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.355 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.346 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.346 N/A N/A a.50.1 Anaphylotoxins (complement system)
View Download 0.344 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.344 N/A N/A a.3.1 Cytochrome c
View Download 0.342 N/A N/A a.4.1 Homeodomain-like
View Download 0.335 N/A N/A a.64.2 Bacteriocin AS-48
View Download 0.333 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.330 N/A N/A d.94.1 HPr-like
View Download 0.329 N/A N/A a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.323 N/A N/A a.39.1 EF-hand
View Download 0.322 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.320 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.309 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.306 N/A N/A d.15.3 MoaD/ThiS
View Download 0.301 N/A N/A a.4.1 Homeodomain-like
View Download 0.298 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.296 N/A N/A a.158.1 F-box domain
View Download 0.292 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.291 N/A N/A a.46.1 Methionine synthase domain
View Download 0.290 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.289 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.288 N/A N/A a.46.1 Methionine synthase domain
View Download 0.286 N/A N/A a.144.2 Ribosomal protein L20
View Download 0.285 N/A N/A a.60.11 Hypothetical protein YjbJ
View Download 0.285 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.284 N/A N/A a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
View Download 0.284 N/A N/A c.9.1 Barstar (barnase inhibitor)
View Download 0.279 N/A N/A a.144.2 Ribosomal protein L20
View Download 0.277 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.273 N/A N/A a.46.1 Methionine synthase domain
View Download 0.273 N/A N/A a.144.2 Ribosomal protein L20
View Download 0.271 N/A N/A a.39.1 EF-hand
View Download 0.271 N/A N/A a.140.1 LEM domain
View Download 0.269 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.269 N/A N/A a.60.11 Hypothetical protein YjbJ
View Download 0.268 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.268 N/A N/A a.39.1 EF-hand
View Download 0.268 N/A N/A a.64.1 Saposin
View Download 0.267 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.266 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.258 N/A N/A a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.258 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.258 N/A N/A d.15.1 Ubiquitin-like
View Download 0.256 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.255 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.250 N/A N/A d.15.1 Ubiquitin-like
View Download 0.250 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.250 N/A N/A a.39.1 EF-hand
View Download 0.249 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.248 N/A N/A a.39.1 EF-hand
View Download 0.244 N/A N/A a.4.1 Homeodomain-like
View Download 0.244 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.244 N/A N/A a.39.1 EF-hand
View Download 0.243 N/A N/A a.118.8 TPR-like
View Download 0.243 N/A N/A a.64.1 Saposin
View Download 0.242 N/A N/A a.4.1 Homeodomain-like
View Download 0.232 N/A N/A a.85.1 Hemocyanin, N-terminal domain
View Download 0.229 N/A N/A a.77.1 DEATH domain
View Download 0.229 N/A N/A d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.227 N/A N/A a.144.2 Ribosomal protein L20
View Download 0.222 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.220 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.219 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.218 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.216 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.215 N/A N/A a.77.1 DEATH domain
View Download 0.214 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.214 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.212 N/A N/A a.4.1 Homeodomain-like
View Download 0.207 N/A N/A a.59.1 PAH2 domain
View Download 0.205 N/A N/A d.26.1 FKBP-like
View Download 0.202 N/A N/A a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.201 N/A N/A a.74.1 Cyclin-like

Predicted Domain #3
Region A:
Residues: [163-392]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKLDQIYKEF DEKTNEKNQC DSPKENQINV ESLNKKVDEV IRTTTFKLKP LMDNYQKILN  60
   61 YQATKKFIEL NKFYFNLPKS LKRCLTNNDF NEFIIEYSKG LTLRRRFNQS SDASQSLVIK 120
  121 RIWTQIENLL VTYKDLIWNS LINSNFNIDQ PQETILSLFS KLLNLENFIN NNQRESESGN 180
  181 KNTTSSSNEN PILRWMSIKM NGFQNELNEL SGHMISKIIH SQRLILQNNT 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.720 N/A N/A a.2.5 Prefoldin
View Download 0.457 N/A N/A a.47.2 t-snare proteins
View Download 0.408 N/A N/A a.47.2 t-snare proteins
View Download 0.403 N/A N/A a.7.1 Spectrin repeat
View Download 0.400 N/A N/A a.7.1 Spectrin repeat

Predicted Domain #4
Region A:
Residues: [393-532]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQDKSQGCVE LSYYLKINQL FQIISDTGKD SEGLKSTVEP NKVNTISGTS YLNLNCQPSS  60
   61 QGLTDSPTII EMWLLILKYI NDLWKICDQF IEFWEHIEKF LDGTYQNSII NEKRKENILI 120
  121 GDSNIIESYQ KSLILKEEQI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.295 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.384 a.118.8 TPR-like
View Download 0.260 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.332 i.11.1 Computational models partly based on NMR data
View Download 0.288 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.260 a.26.1 4-helical cytokines
View Download 0.257 a.133.1 Phospholipase A2, PLA2
View Download 0.250 a.91.1 Regulator of G-protein signalling, RGS
View Download 0.247 a.118.8 TPR-like
View Download 0.236 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.220 a.63.1 Apolipophorin-III
View Download 0.217 a.26.1 4-helical cytokines
View Download 0.215 a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #5
Region A:
Residues: [533-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEVRLKGEEF ITSVSQNLIS FFTSSQSSLP SSLKDSTGDI TRSNKDSGSP LDYGFIPPNC  60
   61 NGLSCLRYLP KIVEPILKFS TELAQLNITT NGITICRNTL STIINRCVGA ISSTKLRDIS 120
  121 NFYQLENWQV YETVTFSSK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.439 0.051 vesicle docking during exocytosis a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.448 0.019 vesicle docking during exocytosis a.19.1 Fertilization protein
View Download 0.597 0.017 vesicle docking during exocytosis a.63.1 Apolipophorin-III
View Download 0.417 0.006 vesicle docking during exocytosis f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.402 N/A N/A a.7.1 Spectrin repeat
View Download 0.377 N/A N/A a.47.2 t-snare proteins
View Download 0.335 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.306 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.301 N/A N/A c.50.1 Macro domain-like
View Download 0.267 N/A N/A a.7.1 Spectrin repeat
View Download 0.264 N/A N/A a.25.1 Ferritin-like
View Download 0.245 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.245 N/A N/A d.95.2 Homing endonucleases
View Download 0.241 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.211 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.204 N/A N/A c.16.1 Lumazine synthase

Predicted Domain #6
Region A:
Residues: [672-725]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQDSSKNLTF EYGVTQFPEI VTSFQEVSIK TTRDLLFAYE KLPIINGISV VSYP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.532 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.568 a.60.12 DNA polymerase beta-like, second domain
View Download 0.449 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.479 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.494 d.58.12 eEF-1beta-like
View Download 0.523 a.60.12 DNA polymerase beta-like, second domain
View Download 0.424 a.4.1 Homeodomain-like
View Download 0.363 a.5.2 UBA-like
View Download 0.343 a.60.12 DNA polymerase beta-like, second domain
View Download 0.323 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.314 a.5.2 UBA-like
View Download 0.307 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.275 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.267 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.262 a.60.12 DNA polymerase beta-like, second domain
View Download 0.260 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.258 d.58.4 Dimeric alpha+beta barrel
View Download 0.251 a.60.1 SAM/Pointed domain
View Download 0.248 a.144.1 PABC (PABP) domain
View Download 0.246 d.15.7 Immunoglobulin-binding domains
View Download 0.244 a.4.1 Homeodomain-like
View Download 0.244 a.5.2 UBA-like
View Download 0.236 a.5.2 UBA-like
View Download 0.233 a.5.2 UBA-like
View Download 0.232 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.232 d.58.3 Protease propeptides/inhibitors
View Download 0.222 d.74.2 C-terminal domain of arginine repressor
View Download 0.222 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.217 d.58.5 GlnB-like
View Download 0.205 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.201 a.5.6 Hypothetical protein MTH1615
View Download 0.201 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain

Predicted Domain #7
Region A:
Residues: [726-971]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKQLLTGIEI QQIISMEAVL EAILKNAAKD KDNPRNSHTI LTLTNLQYFR ECAFPNILQY  60
   61 FDDAFEWNLA SKNLELFSLL SKMESSIFGN YLSDLKINLR DTLEEKFHEI NWPMYTSNSF 120
  121 RVGDYIIEAL MILIVVHSEC FRIGPQLIHK ILIETQIFIA RYLFEAFKPY VGNLSNDGSL 180
  181 QIIVDLEFFQ KVMGPLLEKD TEATLRACLQ NCFQNDTNRL QKCINEINPI VSANLKRTAI 240
  241 QFAAFS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle