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View Structure Prediction Details

Protein: GIR2
Organism: Saccharomyces cerevisiae
Length: 265 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GIR2.

Description E-value Query
Range
Subject
Range
gi|190404892 - gi|190404892|gb|EDV08159.1| protein GIR2 [Saccharomyces cerevisiae RM11-1a]
GIR2 - Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; interacts with Rbg1p an...
gi|151942136 - gi|151942136|gb|EDN60492.1| conserved protein [Saccharomyces cerevisiae YJM789]
gi|207346662 - gi|207346662|gb|EDZ73095.1| YDR152Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GIR2_YEAST - Protein GIR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIR2 PE=1 SV=1
1.0E-65 [1..265] [1..265]
gi|5138918 - gi|5138918|gb|AAD40376.1| PTD013 [Homo sapiens]
3.0E-41 [2..251] [3..209]
RWDD1_RAT - RWD domain-containing protein 1 OS=Rattus norvegicus GN=Rwdd1 PE=2 SV=1
4.0E-41 [2..251] [3..209]
gi|16768964 - gi|16768964|gb|AAL28701.1| LD12396p [Drosophila melanogaster]
2.0E-39 [2..253] [4..212]
gi|7305017, gi|6... - gi|7305017|ref|NP_038747.1| eukaryotic translation initiation factor 2 alpha kinase 4 [Mus musculus]...
7.0E-38 [2..178] [18..180]
gi|23198350, gi|... - pir||C96556 unknown protein [imported] - Arabidopsis thaliana, gi|23198350|gb|AAN15702.1| unknown p...
1.0E-37 [2..234] [3..199]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-36 [2..190] [9..189]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYKEEQKQE LEVLESIYPD ELRIINDEYP KIKFEVAIKL ELDTGDSTSV LTKEHTIIAE  60
   61 FKLPENYPDE PCLISLEAQE VALNDNEEDN EEDEDEVEYD DHGNKVLKKF EN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.502 0.389 cytoplasm a.4.5 "Winged helix" DNA-binding domain
View Download 0.509 0.000 cytoplasm d.129.1 TATA-box binding protein-like
View Download 0.511 0.000 cytoplasm d.236.1 DNA-binding protein Tfx
View Download 0.570 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.561 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.473 N/A N/A d.52.7 Ribosome-binding factor A, RbfA
View Download 0.460 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.434 N/A N/A b.1.18 E set domains
View Download 0.394 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.386 N/A N/A d.199.1 DNA-binding C-terminal domain of the transcription factor MotA
View Download 0.383 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.364 N/A N/A a.24.3 Cytochromes
View Download 0.349 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.327 N/A N/A b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.315 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.315 N/A N/A d.80.1 Tautomerase/MIF
View Download 0.298 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.298 N/A N/A d.15.1 Ubiquitin-like
View Download 0.298 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.294 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.289 N/A N/A b.1.2 Fibronectin type III
View Download 0.289 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.277 N/A N/A d.70.1 Yest killer toxins
View Download 0.269 N/A N/A d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.268 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.258 N/A N/A a.39.1 EF-hand
View Download 0.255 N/A N/A a.24.3 Cytochromes
View Download 0.246 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.244 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.235 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.227 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.226 N/A N/A d.101.1 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
View Download 0.218 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.217 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.210 N/A N/A a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.205 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.203 N/A N/A d.60.1 Probable bacterial effector-binding domain
View Download 0.203 N/A N/A d.20.1 UBC-like
View Download 0.201 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain

Predicted Domain #2
Region A:
Residues: [113-265]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPDLISFKGY LPELTVQLES QIETDMLLGM QMCFALISSI KERCEQWYSE QLNKLEKQYE  60
   61 LEAQEREKKE QAKFHGTKVT RESYLEWRSK FRQELKLDER DQVRRMKAHH GKLTGKQMFE 120
  121 QGVVGTGDEY MEEDDASVDD VAKGLAKTEI ANQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.901 0.281 cytoplasm a.25.1 Ferritin-like
View Download 0.840 0.000 cytoplasm a.63.1 Apolipophorin-III
View Download 0.665 0.000 cytoplasm f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.766 N/A N/A a.63.1 Apolipophorin-III
View Download 0.543 N/A N/A a.25.1 Ferritin-like
View Download 0.539 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.531 N/A N/A a.63.1 Apolipophorin-III
View Download 0.525 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.515 N/A N/A a.63.1 Apolipophorin-III
View Download 0.515 N/A N/A a.118.16 Testis/brain RNA-binding protein (TB-RBP)
View Download 0.511 N/A N/A a.63.1 Apolipophorin-III
View Download 0.501 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.482 N/A N/A a.24.4 Hemerythrin
View Download 0.458 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.454 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.449 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.448 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.440 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.427 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.396 N/A N/A a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.391 N/A N/A a.87.1 DBL homology domain (DH-domain)
View Download 0.389 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.381 N/A N/A a.1.1 Globin-like
View Download 0.380 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.368 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.364 N/A N/A a.87.1 DBL homology domain (DH-domain)
View Download 0.327 N/A N/A a.118.8 TPR-like
View Download 0.321 N/A N/A a.24.4 Hemerythrin
View Download 0.319 N/A N/A d.124.1 Ribonuclease Rh-like
View Download 0.318 N/A N/A d.124.1 Ribonuclease Rh-like
View Download 0.306 N/A N/A d.123.1 Sporulation responce regulatory protein Spo0B
View Download 0.302 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.299 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.292 N/A N/A a.1.1 Globin-like
View Download 0.287 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.287 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.287 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.285 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.285 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.277 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.277 N/A N/A a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.277 N/A N/A a.24.4 Hemerythrin
View Download 0.274 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.270 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.263 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.263 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.262 N/A N/A a.24.12 Outer surface protein C (OspC)
View Download 0.255 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.246 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.242 N/A N/A d.123.1 Sporulation responce regulatory protein Spo0B
View Download 0.238 N/A N/A a.24.4 Hemerythrin
View Download 0.232 N/A N/A d.90.1 NADH oxidase/flavin reductase
View Download 0.226 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.225 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.225 N/A N/A a.26.1 4-helical cytokines
View Download 0.225 N/A N/A a.126.1 Serum albumin-like
View Download 0.224 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.222 N/A N/A a.126.1 Serum albumin-like
View Download 0.218 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.217 N/A N/A a.4.1 Homeodomain-like
View Download 0.215 N/A N/A a.126.1 Serum albumin-like
View Download 0.213 N/A N/A a.7.4 Smac/diablo
View Download 0.213 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.212 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.211 N/A N/A a.22.1 Histone-fold
View Download 0.211 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.209 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.206 N/A N/A a.39.1 EF-hand
View Download 0.204 N/A N/A d.50.1 dsRNA-binding domain-like
View Download 0.201 N/A N/A a.24.9 alpha-catenin/vinculin


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle