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View Structure Prediction Details

Protein: GYP7
Organism: Saccharomyces cerevisiae
Length: 746 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GYP7.

Description E-value Query
Range
Subject
Range
GYP7 - GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt...
gi|190405222 - gi|190405222|gb|EDV08489.1| GTPase-activating protein GYP7 [Saccharomyces cerevisiae RM11-1a]
GYP7_YEAST - GTPase-activating protein GYP7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GYP7 PE=1...
0.0 [1..746] [1..746]
gi|16944459 - gi|16944459|emb|CAC18154.2| probable GTPase activating protein [Neurospora crassa]
0.0 [10..707] [83..774]
GYP7_YARLI - GTPase-activating protein GYP7 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=GYP7 PE=3 SV=2
GYP7_YARLI - GTPase-activating protein GYP7 OS=Yarrowia lipolytica GN=GYP7 PE=3 SV=2
0.0 [10..742] [20..725]
gyp7 - GTPase activating protein Gyp7
GYP7_SCHPO - GTPase-activating protein gyp7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gyp7 PE=3 S...
0.0 [4..729] [31..730]
TBC1D17 - TBC1 domain family, member 17
0.0 [3..716] [7..605]
gi|21450327, gi|... - gi|21450327|ref|NP_659173.1| TBC1 domain family, member 17 [Mus musculus], gi|17160868|gb|AAH17607.1...
2.0E-96 [3..628] [7..515]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-80 [140..746] [493..1038]

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Predicted Domain #1
Region A:
Residues: [1-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKILFCKSK VFLHPTSDAR DNIAGFLLLT LEANKLSHQA ILQYIPESGL STLEISKLLK  60
   61 HEAKVGTCPT STPFVIENSI NFSNLVNTSL GQAFEISLSQ IYCIQFRPPS PNGWYVGSLV 120
  121 IYPLTEQFTG FQPPVLFFHD QLCPSTTDKL KRLRKSMNPF DDSDELYWGG VDLRNKINEL 180
  181 MELKKSNLEP EFWLVNPSLN DLRNFVSKDL LESYNNSKKD TTELATAGVK LNEKFQEWKW 240
  241 NVMSKIADVT 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [251-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKSTNFIDSW LTNNSPIQKS QIDNEYLQKL LNNEKVKQIE QDYDSARVYL ANWSLGVKQE  60
   61 AERYQKQNKL FDSYRNNIFN DLNLTDELSD TEINNALQRQ FP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.769 a.1.1 Globin-like
View Download 0.541 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.540 a.74.1 Cyclin-like
View Download 0.531 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.523 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.509 a.118.1 ARM repeat
View Download 0.483 a.118.11 Cytochrome c oxidase subunit E
View Download 0.476 a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.450 a.46.1 Methionine synthase domain
View Download 0.439 a.74.1 Cyclin-like
View Download 0.434 a.74.1 Cyclin-like
View Download 0.416 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.376 d.19.1 MHC antigen-recognition domain
View Download 0.352 a.25.1 Ferritin-like
View Download 0.350 a.61.1 Retroviral matrix proteins
View Download 0.331 a.77.1 DEATH domain
View Download 0.319 a.7.7 BAG domain
View Download 0.316 a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.305 a.51.1 Cytochrome c oxidase subunit h
View Download 0.285 b.49.2 Alanine racemase C-terminal domain-like
View Download 0.279 a.7.1 Spectrin repeat
View Download 0.271 a.85.1 Hemocyanin, N-terminal domain
View Download 0.271 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.269 a.24.17 Group V grass pollen allergen
View Download 0.267 d.8.1 Urease, gamma-subunit
View Download 0.265 d.58.49 YajQ-like
View Download 0.262 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.254 d.42.1 POZ domain
View Download 0.250 a.3.1 Cytochrome c
View Download 0.249 a.118.9 ENTH/VHS domain
View Download 0.243 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.243 a.77.1 DEATH domain
View Download 0.236 a.79.1 Antitermination factor NusB
View Download 0.231 a.3.1 Cytochrome c
View Download 0.229 a.130.1 Chorismate mutase II
View Download 0.227 a.39.1 EF-hand
View Download 0.214 d.137.1 Monooxygenase (hydroxylase) regulatory protein
View Download 0.212 a.138.1 Multiheme cytochromes
View Download 0.212 a.1.1 Globin-like
View Download 0.212 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.209 a.74.1 Cyclin-like
View Download 0.206 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.200 a.26.1 4-helical cytokines

Predicted Domain #3
Region A:
Residues: [353-570]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEAKWNSLW DENDGRLRVT VNEVKDFIFH GGLENDSLRG KVWGFLLEIY PWDSSQDERV  60
   61 QIDQTLAAEY DQLKLTWSKD FLQFDDEDEE EYWNDQLFRI SKDVRRCDRN LEIFQYNTID 120
  121 GLPPPPQQLP ANENNSTSPE SANDESDDAD DGVRNPHLIH LQNILITYNV YNTNLGYVQG 180
  181 MTDLLSPIYV IMKEEWKTFW CFTHFMDIME RNFLRDQS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [624-632]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HIWENFWTF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 101.0103
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [571-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIHEQMLTLV ELVQLMLPEL SEHLNKCDSG NLFFCFRMLL VWFKREFEME DIM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 101.0103
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [633-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YYSSQFQLFF MLAILQKNSQ AILQHLNQFD QILKFFNELN GKLDWNDLMV RAELLFKKFE  60
   61 KMMHVMERDL QNVSSSSSSS STGVLPCQSE RLTLLLSKKP IIRHEGQRSK NSVK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.836 0.229 Rab GTPase activator activity a.21.1 HMG-box
View Download 0.442 0.112 Rab GTPase activator activity a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.449 0.009 Rab GTPase activator activity a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.549 N/A N/A a.21.1 HMG-box
View Download 0.434 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.379 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.372 N/A N/A a.7.1 Spectrin repeat
View Download 0.345 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.329 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.320 N/A N/A a.74.1 Cyclin-like
View Download 0.320 N/A N/A a.7.7 BAG domain
View Download 0.304 N/A N/A a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.299 N/A N/A a.77.1 DEATH domain
View Download 0.279 N/A N/A d.129.4 Cell-division protein ZipA, C-terminal domain
View Download 0.259 N/A N/A a.46.1 Methionine synthase domain
View Download 0.257 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.242 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.242 N/A N/A a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.238 N/A N/A a.4.1 Homeodomain-like
View Download 0.236 N/A N/A d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain
View Download 0.233 N/A N/A a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.230 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.228 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.227 N/A N/A a.47.2 t-snare proteins
View Download 0.226 N/A N/A a.26.1 4-helical cytokines
View Download 0.223 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.218 N/A N/A a.77.1 DEATH domain
View Download 0.212 N/A N/A a.1.1 Globin-like
View Download 0.211 N/A N/A a.25.1 Ferritin-like
View Download 0.211 N/A N/A a.1.1 Globin-like
View Download 0.209 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.209 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.208 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.201 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle