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View Structure Prediction Details

Protein: CDC53
Organism: Saccharomyces cerevisiae
Length: 815 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC53.

Description E-value Query
Range
Subject
Range
CDC53_YEAST - Cell division control protein 53 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC53 P...
CDC53 - Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box pr...
0.0 [1..815] [1..815]
CUL1 - cullin 1
CUL1_PONPY - Cullin-1 - Pongo pygmaeus (Orangutan)
CUL1_PONAB - Cullin-1 OS=Pongo abelii GN=CUL1 PE=2 SV=1
gi|114616601, gi... - gi|114616611|ref|XP_001165597.1| PREDICTED: cullin 1 isoform 12 [Pan troglodytes], gi|114616609|ref|...
0.0 [3..815] [9..776]
gi|224044991 - gi|224044991|ref|XP_002198372.1| PREDICTED: hypothetical protein [Taeniopygia guttata]
gi|363730292|ref... - PREDICTED: cullin-1 [Gallus gallus]
gi|542154239|ref... - PREDICTED: cullin-1 [Zonotrichia albicollis]
CUL1_MOUSE - Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1
gi|62647154, gi|... - gi|62647154|ref|XP_342680.2| PREDICTED: similar to Cullin-1 (CUL-1) [Rattus norvegicus], gi|17184707...
0.0 [3..815] [9..776]
gi|66801663, gi|... - gi|66801663|ref|XP_629756.1| cullin [Dictyostelium discoideum AX4], gi|60463149|gb|EAL61342.1| culli...
CUL1_DICDI - Cullin-1 OS=Dictyostelium discoideum GN=culA PE=1 SV=1
0.0 [1..815] [3..770]
CUL1_ARATH - Cullin-1 OS=Arabidopsis thaliana GN=CUL1 PE=1 SV=1
0.0 [5..815] [2..738]
gi|14091836 - gi|14091836|gb|AAK53839.1|AC011806_16 Putative cullin [Oryza sativa]
gi|125570399 - gi|125570399|gb|EAZ11914.1| hypothetical protein OsJ_001739 [Oryza sativa (japonica cultivar-group)]
0.0 [1..815] [1..750]
cul1 - cullin 1
CUL1_SCHPO - Cullin-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cul1 PE=1 SV=1
0.0 [3..815] [12..767]
gi|19577357 - gi|19577357|emb|CAD28438.1| putative scf complex protein [Aspergillus fumigatus]
0.0 [32..815] [5..747]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETLPRSDD LEATWNFIEP GINQILGNEK NQASTSKRVY KILSPTMYME VYTAIYNYCV  60
   61 NKSRSSGHFS TDSRTGQSTI LVGSEIYEKL KNYLK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [122-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGAIFLNHAF DYMNRYWVQK ERSDGKRHIF DVNT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2110.0
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 9.95820721075934 bayes_pls_golite062009
small conjugating protein ligase activity 9.63704265478699 bayes_pls_golite062009
acid-amino acid ligase activity 8.59660059921406 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 7.32718329074249 bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity 6.69190468636718 bayes_pls_golite062009
transcription regulator activity 4.76121492612224 bayes_pls_golite062009
ligase activity 4.08678005991666 bayes_pls_golite062009
transcription factor activity 3.7855017556511 bayes_pls_golite062009
binding 2.45185337633142 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
transcription activator activity 2.05043065144612 bayes_pls_golite062009
nucleic acid binding 1.54797684894025 bayes_pls_golite062009
DNA binding 1.42215436462553 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.23862224095769 bayes_pls_golite062009
transporter activity 0.891050405674973 bayes_pls_golite062009
transmembrane transporter activity 0.648150681919233 bayes_pls_golite062009
transcription factor binding 0.612315945412079 bayes_pls_golite062009
substrate-specific transporter activity 0.368917395770011 bayes_pls_golite062009
catalytic activity 0.351553138703956 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.146182977030285 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
structure-specific DNA binding 0.117670813298683 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.107671044044222 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009
sequence-specific DNA binding 0.0102780098866235 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [96-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYILNFKQSN SETFLQFYVK RWKRFT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [156-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LCLMTWKEVM FDPSKDVLIN ELLDQVTLGR EGQIIQRSNI STAIKSLVAL GIDPQDLKKL  60
   61 NLNVYIQVFE KPFLKKTQEY YTQYTNDYLE KHSVTEYIFE AHEIIKREEK AMTIYWDDHT 120
  121 KKPLSMALNK VLITDHIEKL EN

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [311-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITSLYALIRR DFTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2110.0
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [298-310]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFVVLLDARD IEK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [325-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPRMASVFEN YVKKTGENEI SSLLAMHKHN IMKNENANPK KLALMTAHSL SPKDYIKKLL  60
   61 EVHDIFSKIF NESFPDDIPL AKALDNACGA FININEFALP AGSPKSATSK TSEMLAKYSD 120
  121 ILLKKATKPE VASDMSDEDI ITIFKYLTDK DAFETHYRRL FAKRLIHGTS TSAEDEENII 180
  181 QRLQAANSME YTGKITKMFQ DI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2110.0
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [527-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLSKILEDDF AVALKNEPDY SKAKYPDLQP FVLAENMWPF SYQEVEFKLP KELVPSHEKL  60
   61 KESYSQKHNG RILKWL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2110.0
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [603-742]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WPLCRGELKA DIGKPGRMPF NFTVTLFQMA ILLLYNDADV LTLENIQEGT SLTIQHIAAA  60
   61 MVPFIKFKLI QQVPPGLDAL VKPETQFKLS RPYKALKTNI NFASGVKNDI LQSLSGGGHD 120
  121 NHGNKLGNKR LTEDERIEKE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2110.0
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [743-815]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNTERQIFLE ACIVRIMKAK RNLPHTTLVN ECIAQSHQRF NAKVSMVKRA IDSLIQKGYL  60
   61 QRGDDGESYA YLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2110.0
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle