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View Structure Prediction Details

Protein: HNT1
Organism: Saccharomyces cerevisiae
Length: 158 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNT1.

Description E-value Query
Range
Subject
Range
HNT1 - Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK ...
gi|151941878 - gi|151941878|gb|EDN60234.1| histidine triad nucleotide-binding protein [Saccharomyces cerevisiae YJM...
HNT1_YEAST - Hit family protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HNT1 PE=1 SV=2
3.0E-42 [1..158] [1..158]
gi|7515016, gi|5... - pir||E75192 hit family protein (hit). PAB2301 - Pyrococcus abyssi (strain Orsay), gi|5457497|emb|CA...
gi|14520282, gi|... - gi|5457497|emb|CAB48988.1| hit histidine triad protein [Pyrococcus abyssi GE5], gi|14520282|ref|NP_1...
1.0E-41 [4..158] [20..178]
gi|7434504 - pir||F71224 hypothetical protein PH0057 - Pyrococcus horikoshii
gi|14590010, gi|... - gi|3256442|dbj|BAA29125.1| 168aa long hypothetical protein [Pyrococcus horikoshii OT3], gi|14590010|...
2.0E-41 [4..158] [3..161]
gi|18976380, gi|... - gi|18976380|ref|NP_577737.1| hit family protein [Pyrococcus furiosus DSM 3638], gi|18891904|gb|AAL80...
4.0E-41 [4..158] [3..161]
gi|15920488, gi|... - gi|15920488|ref|NP_376157.1| bis(5'-adenosyl)-triphosphatase [Sulfolobus tokodaii str. 7], gi|156212...
8.0E-39 [4..155] [3..161]
HIT_BACSU - Protein hit OS=Bacillus subtilis (strain 168) GN=hit PE=1 SV=1
gi|221322363 - gi|221322363|ref|ZP_03603657.1| Hit-like protein [Bacillus subtilis subsp. subtilis str. SMY]
HIT_BACSU - Protein hit OS=Bacillus subtilis GN=hit PE=1 SV=1
gi|221313165 - gi|221313165|ref|ZP_03594970.1| Hit-like protein [Bacillus subtilis subsp. subtilis str. NCIB 3610]
gi|221318088 - gi|221318088|ref|ZP_03599382.1| Hit-like protein [Bacillus subtilis subsp. subtilis str. JH642]
1.0E-37 [22..157] [4..145]
Y866_METJA - Uncharacterized HIT-like protein MJ0866 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 26...
Y866_METJA - Uncharacterized HIT-like protein MJ0866 OS=Methanocaldococcus jannaschii GN=MJ0866 PE=4 SV=2
1.0E-37 [25..151] [2..128]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-37 [25..151] [2..128]
gi|241768853, gi... - gi|241768853|ref|ZP_04766277.1| histidine triad (HIT) protein [Sulfolobus solfataricus 98/2], gi|241...
gi|25288052 - pir||E90166 HIT-like protein, hypothetical (hit) [imported] - Sulfolobus solfataricus
gi|13813386, gi|... - gi|15897193|ref|NP_341798.1| HIT-like protein [Sulfolobus solfataricus P2], gi|13813386|gb|AAK40588....
1.0E-36 [4..157] [3..163]
gi|25288050 - pir||E83798 Hit-like protein involved in cell-cycle regulation hit [imported] - Bacillus halodurans ...
gi|10173805, gi|... - gi|15613752|ref|NP_242055.1| Hit-like protein involved in cell-cycle regulation [Bacillus halodurans...
2.0E-36 [22..154] [4..142]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPLISAPYL TTTKMSAPAT LDAACIFCKI IKSEIPSFKL IETKYSYAFL DIQPTAEGHA  60
   61 LIIPKYHGAK LHDIPDEFLT DAMPIAKRLA KAMKLDTYNV LQNNGKIAHQ EVDHVHFHLI 120
  121 PKRDEKSGLI VGWPAQETDF DKLGKLHKEL LAKLEGSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 124.0
Match: 1av5A_
Description: Protein kinase C inhibitor-1, PKCI-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.71599870633602 bayes_pls_golite062009
nucleic acid binding 0.724655038971066 bayes_pls_golite062009
protein binding 0.315946879872005 bayes_pls_golite062009
catalytic activity 0.096119422680995 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle