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View Structure Prediction Details

Protein: POL3
Organism: Saccharomyces cerevisiae
Length: 1097 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POL3.

Description E-value Query
Range
Subject
Range
gi|3480 - gi|3480|emb|CAA33504.1| unnamed protein product [Saccharomyces cerevisiae]
0.0 [1..1097] [1..1093]
DPOD_MOUSE, DPOD... - (P52431) DNA polymerase delta catalytic subunit (EC 2.7.7.7), DNA polymerase delta catalytic subunit...
0.0 [45..1097] [13..1097]
DPOD1_MESAU - DNA polymerase delta catalytic subunit OS=Mesocricetus auratus GN=POLD1 PE=2 SV=1
0.0 [45..1097] [13..1095]
DPOD1_BOVIN - DNA polymerase delta catalytic subunit OS=Bos taurus GN=POLD1 PE=1 SV=1
0.0 [69..1097] [49..1098]
DPOD1_RAT - DNA polymerase delta catalytic subunit OS=Rattus norvegicus GN=Pold1 PE=2 SV=1
0.0 [45..1097] [13..1095]
gi|157929094, gi... - gi|157929094|gb|ABW03832.1| polymerase (DNA directed), delta 1, catalytic subunit 125kDa [synthetic ...
gi|14250670 - gi|14250670|gb|AAH08800.1| Polymerase (DNA directed), delta 1, catalytic subunit 125kDa [Homo sapien...
0.0 [69..1097] [49..1099]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKRSLPMV DVKIDDEDTP QLEKKIKRQS IDHGVGSEPV STIEIIPSDS FRKYNSQGFK  60
   61 AKDTDLMGTQ LESTF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [76-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQDVSQMEHD MADQEEHDLS SFERKKLPTD FDPSLYDISF QQIDAEQSVL NGIKDENTST  60
   61 VVRFFGVTSE GHSVLCNVTG FK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [251-578]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIAYTLRLMV DCGIVGMSWI TLPKGKYSMI EPNNRVSSCQ LEVSINYRNL IAHPAEGDWS  60
   61 HTAPLRIMSF DIECAGRIGV FPEPEYDPVI QIANVVSIAG AKKPFIRNVF TLNTCSPITG 120
  121 SMIFSHATEE EMLSNWRNFI IKVDPDVIIG YNTTNFDIPY LLNRAKALKV NDFPYFGRLK 180
  181 TVKQEIKESV FSSKAYGTRE TKNVNIDGRL QLDLLQFIQR EYKLRSYTLN AVSAHFLGEQ 240
  241 KEDVHYSIIS DLQNGDSETR RRLAVYCLKD AYLPLRLMEK LMALVNYTEM ARVTGVPFSY 300
  301 LLARGQQIKV VSQLFRKCLE IDTVIPNM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1532.218487
Match: 1tgoA_
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [158-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYLYVPAPNS SDANDQEQIN KFVHYLNETF DHAIDSIEVV SKQSIWGYSG DTKLPFWKIY  60
   61 VTYPHMVNKL RTAFERGHLS FNSWFSNGTT TYD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [579-589]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSQASDDQYE G

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [611-731]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLYPSIMMAH NLCYTTLCNK ATVERLNLKI DEDYVITPNG DYFVTTKRRR GILPIILDEL  60
   61 ISARKRAKKD LRDEKDPFKR DVLNGRQLAL KISANSVYGF TGATVGKLPC LAISSSVTAY 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1532.218487
Match: 1tgoA_
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [590-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATVIEPIRGY YDVPIATLDF N

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [732-833]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTMILKTKTA VQEKYCIKNG YKHDAVVVYG DTDSVMVKFG TTDLKEAMDL GTEAAKYVST  60
   61 LFKHPINLEF EKAYFPYLLI NKKRYAGLFW TNPDKFDKLD QK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1532.218487
Match: 1tgoA_
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [834-1007]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLASVRRDSC SLVSIVMNKV LKKILIERNV DGALAFVRET INDILHNRVD ISKLIISKTL  60
   61 APNYTNPQPH AVLAERMKRR EGVGPNVGDR VDYVIIGGND KLYNRAEDPL FVLENNIQVD 120
  121 SRYYLTNQLQ NPIISIVAPI IGDKQANGMF VVKSIKINTG SQKGGLMSFI KKVE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1532.218487
Match: 1tgoA_
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1008-1097]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ACKSCKGPLR KGEGPLCSNC LARSGELYIK ALYDVRDLEE KYSRLWTQCQ RCAGNLHSEV  60
   61 LCSNKNCDIF YMRVKVKKEL QEKVEQLSKW 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle