YRC Public Data Repository - Protein Structure Prediction

Protein:	YDL086W
Organism:	Saccharomyces cerevisiae
Length:	273 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDL086W.

Description	E-value	Query Range	Subject Range
DLHH_YEAST - Putative carboxymethylenebutenolidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YD... YDL086W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purifi...	4.0E-46	[1..273]	[1..273]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-41	[3..237]	[458..702]
gi\|2635720, gi\|1... - gi\|2635720\|emb\|CAB15213.1\| yuxL [Bacillus subtilis subsp. subtilis str. 168], gi\|16080276\|ref\|NP_391... YUXL_BACSU - Uncharacterized peptidase yuxL OS=Bacillus subtilis GN=yuxL PE=3 SV=2	1.0E-40	[5..255]	[401..657]
gi\|25530228 - pir\|\|AB2404 hypothetical protein alr4786 [imported] - Nostoc sp. (strain PCC 7120) gi\|17232278, gi\|... - gi\|17232278\|ref\|NP_488826.1\| hypothetical protein alr4786 [Nostoc sp. PCC 7120], gi\|17133923\|dbj\|BAB...	4.0E-40	[2..255]	[15..249]
DLHH_YERPE - Putative carboxymethylenebutenolidase OS=Yersinia pestis GN=YPO3787 PE=3 SV=1 gi\|89104873 - gi\|89104873\|ref\|ZP_01177404.1\| COG0412: Dienelactone hydrolase and related enzymes [Yersinia pestis ... gi\|77633876 - gi\|77633876\|ref\|ZP_00795990.1\| COG0412: Dienelactone hydrolase and related enzymes [Yersinia pestis ... gi\|153997156, gi... - gi\|153997156\|ref\|ZP_02022289.1\| putative carboxymethylenebutenolidase [Yersinia pestis CA88-4125], g... gi\|229837113, gi... - gi\|229837113\|ref\|ZP_04457278.1\| putative carboxymethylenebutenolidase [Yersinia pestis Pestoides A],... gi\|229695838, gi... - gi\|229839472\|ref\|ZP_04459631.1\| putative carboxymethylenebutenolidase [Yersinia pestis biovar Orient... gi\|229900035, gi... - gi\|229900035\|ref\|ZP_04515172.1\| putative carboxymethylenebutenolidase [Yersinia pestis biovar Orient... gi\|115349400, gi... - gi\|218930789\|ref\|YP_002348664.1\| putative carboxymethylenebutenolidase [Yersinia pestis CO92], gi\|16... gi\|229900518, gi... - gi\|229900518\|ref\|ZP_04515647.1\| putative carboxymethylenebutenolidase [Yersinia pestis Nepal516], gi...	2.0E-39	[9..254]	[24..255]
gi\|7520884 - pir\|\|H72474 probable acylamino-acid-releasing enzyme APE2441 - Aeropyrum pernix (strain K1) gi\|5106145, gi\|1... - gi\|5106145\|dbj\|BAA81456.1\| 591aa long hypothetical acylamino-acid-releasing enzyme [Aeropyrum pernix...	3.0E-39	[3..238]	[334..580]
gi\|25499550, gi\|... - gi\|25499550\|pir\|\|F86070 probable enzyme Z5352 [imported] - Escherichia coli (strain O157:H7, substra... gi\|12518707, gi\|... - gi\|15804422\|ref\|NP_290462.1\| putative enzyme [Escherichia coli O157:H7 EDL933], gi\|12518707\|gb\|AAG59... gi\|13364236, gi\|... - gi\|15834014\|ref\|NP_312787.1\| hypothetical protein ECs4760 [Escherichia coli O157:H7], gi\|13364236\|db... gi\|13364236, gi\|... - gi\|15834014\|ref\|NP_312787.1\| hypothetical protein ECs4760 [Escherichia coli O157:H7 str. Sakai], gi\|...	4.0E-39	[3..254]	[50..287]
gi\|14586439 - gi\|14586439\|emb\|CAC42932.1\| dipeptidyl peptidase IV [Prevotella albensis]	8.0E-39	[4..256]	[474..730]
gi\|5459016, gi\|7... - pir\|\|H75007 probable acylaminoacyl-peptidase (EC 3.4.19.1) PAB1300 [similarity] - Pyrococcus abyssi ... gi\|14521796, gi\|... - gi\|5459016\|emb\|CAB50502.1\| apeH acylamino-acid-releasing enzyme (EC 3.4.19.1) (acyl-peptide hydrolas...	9.0E-39	[4..256]	[372..629]
gi\|1657787\|gb\|AA... - orf2 [Methylobacterium extorquens] DLHH_METEX - Putative carboxymethylenebutenolidase OS=Methylobacterium extorquens PE=3 SV=1	4.0E-38	[7..254]	[55..288]

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Predicted Domain #1

Region A:
Residues: [1-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLITETFHDV QTSYGTTLRI YVYSPKIAGY PQAKFPGVIL YSEIYQVTGP VRRFGQRIAS  60
   61 EGYVVVAPAI YHNFMGPEAL PYDVQGTDIG NEYKIKKPLE SYDEDNKLCC DLLFQLPQFD 120
  121 GKRIGSTGMC LGGHLAFRAL LDKRVTCATC FFPTDIHSRT LGLGQNDNSL ERVSKELGNN 180
  181 QEMVLIFGTA DTHVDPQGRD LIRKTLRDHG VKFTFLEILA AQHAFIRDEF SKGRFDSAIT 240
  241 QSCLGFLFEQ FNRKLRIDLG EFVDDNTPLE HVC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.69897
Match:	1qfsA_
Description:	Prolyl oligopeptidase, N-terminal domain; Prolyl oligopeptidase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	1.75934962198703	bayes_pls_golite062009
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.81726006983431	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: