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View Structure Prediction Details

Protein: MRK1
Organism: Saccharomyces cerevisiae
Length: 501 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRK1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [26..491] [8..471]
gi|3236117 - gi|3236117|emb|CAA11861.1| shaggy kinase 6 [Petunia x hybrida]
0.0 [26..491] [8..470]
gi|10185114 - gi|10185114|emb|CAC08564.1| wound-induced GSK-3-like protein [Medicago sativa subsp. x varia]
0.0 [26..490] [8..467]
MSK1_MEDSA - Glycogen synthase kinase-3 homolog MsK-1 OS=Medicago sativa GN=MSK-1 PE=2 SV=1
0.0 [102..492] [17..405]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDVLRSLVR KISFNNSDNL QLKHKTSIQS NTALEKKKRK PDTIKKVSDV QVHHTVPNFN  60
   61 NSSEYINDIE NLIISKLIDG GKEGIAVDHI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [91-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHANISDSKT DGKVANKHEN ISSKLSKEKV EKMINFDYRY IKTKERTIHK RVYKHDRKTD  60
   61 VDRKNHGGTI DISYPTTEVV GHGSFGVVVT TVIIETNQKV AIKKVLQDRR YKNRELETMK 120
  121 MLCHPNTVGL QYYFYEKDEE DEVYLNLVLD Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1073.9897
Match: 1i09A_
Description: Glycogen synthase kinase-3 beta (Gsk3b)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.68265749805481 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
structural molecule activity 3.82327979736517 bayes_pls_golite062009
MAP kinase 2 activity 3.27009208121248 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.41610417530517 bayes_pls_golite062009
histone kinase activity (H3-S10 specific) 2.30449166929476 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
acetylcholine receptor activator activity 2.19834311533772 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
cation transmembrane transporter activity 1.93176092222748 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
ion transmembrane transporter activity 1.90354666768303 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
molecular transducer activity 1.79921740914853 bayes_pls_golite062009
signal transducer activity 1.79921740914853 bayes_pls_golite062009
telethonin binding 1.75733591474207 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.71452519680794 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.68012041942855 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.45392497707807 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.4045088027491 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.4045088027491 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.27184436658773 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.2662335835562 bayes_pls_golite062009
insulin receptor activity 1.22442673174261 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription elongation regulator activity 1.16995153203536 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.0383359654359 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.03605423743048 bayes_pls_golite062009
SMAD binding 1.02108562119195 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
PTB domain binding 0.9900774724568 bayes_pls_golite062009
transmembrane receptor activity 0.913893847407112 bayes_pls_golite062009
alpha-actinin binding 0.877087652539674 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
receptor activity 0.775180603313375 bayes_pls_golite062009
receptor serine/threonine kinase binding 0.728917900114111 bayes_pls_golite062009
transforming growth factor beta receptor binding 0.705634826374884 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 0.705634826374884 bayes_pls_golite062009
hormone receptor binding 0.705067960165986 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.666159109886349 bayes_pls_golite062009
activin binding 0.664317770352101 bayes_pls_golite062009
insulin binding 0.614254468447749 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.595111702412257 bayes_pls_golite062009
activin receptor activity 0.558143200755109 bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity 0.529121666062889 bayes_pls_golite062009
steroid hormone receptor binding 0.505233004492768 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
fibroblast growth factor binding 0.470448662251808 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
transmembrane transporter activity 0.41384976209545 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
potassium channel regulator activity 0.359831178301818 bayes_pls_golite062009
axon guidance receptor activity 0.330635248803668 bayes_pls_golite062009
ephrin receptor activity 0.320275111520979 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
cation channel activity 0.245400615103891 bayes_pls_golite062009
nuclear hormone receptor binding 0.240883589532225 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
growth factor binding 0.153144089598532 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.114318824149111 bayes_pls_golite062009
substrate-specific transporter activity 0.0922946791401962 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [242-501]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQSLYQRLR HFVNLKMQMP RVEIKFYAYQ LFKALNYLHN VPRICHRDIK PQNLLVDPTT  60
   61 FSFKICDFGS AKCLKPDQPN VSYICSRYYR APELMFGATN YSNQVDVWSS ACVIAELLLG 120
  121 KPLFSGESGI DQLVEIIKIM GIPTKDEISG MNPNYEDHVF PNIKPITLAE IFKAEDPDTL 180
  181 DLLTKTLKYH PCERLVPLQC LLSSYFDETK RCDTDTYVKA QNLRIFDFDV ETELGHVPLV 240
  241 ERPAIEERLK HFVSAPSSSL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1073.9897
Match: 1i09A_
Description: Glycogen synthase kinase-3 beta (Gsk3b)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle