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View Structure Prediction Details

Protein: MED2
Organism: Saccharomyces cerevisiae
Length: 431 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED2.

Description E-value Query
Range
Subject
Range
gi|7494359, gi|2... - pir||T09080 probable chloroquine resistance protein CG2 (strain HB3) - malaria parasite (Plasmodium ...
176.0 [0..69] [430..2088]
gi|7494193 - pir||T18427 hypothetical protein C0335c - malaria parasite (Plasmodium falciparum)
gi|16805171, gi|... - gi|3649755|emb|CAB11104.1| conserved Plasmodium protein, unknown function [Plasmodium falciparum 3D7...
169.0 [0..40] [430..860]
CE23293 - status:Partially_confirmed UniProt:Q9NAL5 protein_id:CAB76739.1
137.0 [0..82] [396..42]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVQNSPVSS VHTANFSERG SNTRTMTYKN KLTVCFDDIL KVGAEMMMQQ QLKNVQLDSY  60
   61 LVNGFSQSQQ KLLKEKVKLF HGILDDLETS LSQSSSYLET LTALGKEKEK EREEAEKKRA 120
  121 EQENMRKVRE QE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.831 a.24.9 alpha-catenin/vinculin
View Download 0.747 a.29.6 Description not found.
View Download 0.746 a.24.9 alpha-catenin/vinculin
View Download 0.732 a.29.6 Description not found.
View Download 0.728 a.24.9 alpha-catenin/vinculin
View Download 0.693 a.24.14 FAT domain of focal adhesion kinase
View Download 0.672 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.642 a.7.7 BAG domain
View Download 0.634 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.530 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore

Predicted Domain #2
Region A:
Residues: [133-206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELKKRQELEE ASQQQQLQQN SKEKNGLGLN FSTTAPANTT DANGSKENYQ ELGSLQSSSQ  60
   61 TQLENANAAN NGAA

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.93
Match:
Description: No description for 1l8mA was found.

Predicted Domain #3
Region A:
Residues: [207-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSPLTTTRIQ SQQAQPSDVM FNDLNSMDIS MFSGLDSTGF DSTAFNATVD ETKGFDDNDS  60
   61 GNNYNDINIS SIENNINNNI 

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.93
Match:
Description: No description for 1l8mA was found.

Predicted Domain #4
Region A:
Residues: [287-356]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSTKNGKDNN NESNKNNNGD EKNKNNNEDN ENNNNSSEKN NNNNNNNNNN NDDNGNNNNN  60
   61 NSGNDNNNTT 

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.93
Match:
Description: No description for 1l8mA was found.

Predicted Domain #5
Region A:
Residues: [357-431]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNDSNNKNNS ITTGNDNENI VNNDLPTTVV SNPGDNPPPA DNGEEYLTLN DFNDLNIDWS  60
   61 TTGDNGELDL SGFNI

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.93
Match:
Description: No description for 1l8mA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle