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View Structure Prediction Details

Protein: RAD18
Organism: Saccharomyces cerevisiae
Length: 487 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAD18.

Description E-value Query
Range
Subject
Range
gi|67900644, gi|... - gi|67900644|ref|XP_680578.1| UVSH_EMENI Postreplication repair protein uvsH/nuvA [Aspergillus nidula...
305.0 [0..4] [453..6]
UVSH_EMENI, RAD1... - (Q02398) Postreplication repair protein uvsH/nuvA, Postreplication repair E3 ubiquitin-protein ligas...
RAD18_EMENI - Postreplication repair E3 ubiquitin-protein ligase rad18 OS=Emericella nidulans (strain FGSC A4 / AT...
305.0 [0..4] [453..6]
gi|76669283 - gi|76669283|ref|XP_592353.2| PREDICTED: similar to tripartite motif-containing 6 isoform 1 [Bos taur...
257.0 [0..13] [335..126]
gi|114635843 - gi|114635843|ref|XP_001162929.1| PREDICTED: tripartite motif-containing 6 isoform 1 [Pan troglodytes...
256.0 [0..13] [298..64]
gi|109108228 - gi|109108228|ref|XP_001105694.1| PREDICTED: ring finger protein 18 isoform 1 [Macaca mulatta]
253.0 [0..14] [302..1]
gi|85106563 - gi|85106563|ref|XP_962209.1| PROTEIN UVS-2 [Neurospora crassa OR74A]
gi|28923808, gi|... - gi|32408171|ref|XP_324567.1| PROTEIN UVS-2 [Neurospora crassa], gi|28923808|gb|EAA32973.1| PROTEIN U...
249.0 [0..5] [429..11]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHQITTASD FTTTSIPSLY QLDTLLRCHI CKDFLKVPVL TPCGHTFCSL CIRTHLNNQP  60
   61 NCPLCLFEFR ESLLRSEFLV SEIIQSYTSL RSSLLDALRI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.70927
Match: 1jm7A
Description: brca1 RING domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [101-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKPTPVPENE EVPGPENSSW IELISESESD SVNAADDDLQ IV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.39794
Match: 1freA
Description: XNF7 BBOX, DEVELOPMENTAL PROTEIN, PH 7.5, 30 C, WITH ZINC, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [143-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATSERKLAKR SMTDILPLSS KPSKRNFAMF RSERIKKKSK PNEQMAQCPI CQQFYPLKAL  60
   61 EKTHLDECLT LQSLGKKPKI STTFPTESNP HNKSSSRFKV RTPEVDKSSC GETSHVDKYL 120
  121 NSMM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.465 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.465 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.359 d.58.55 Description not found.
View Download 0.339 a.74.1 Cyclin-like
View Download 0.324 c.48.1 TK C-terminal domain-like
View Download 0.320 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.319 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.314 a.118.8 TPR-like
View Download 0.230 a.29.4 RecG, N-terminal domain

Predicted Domain #4
Region A:
Residues: [267-343]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAEHQRLPKI NFTSMTQSQI KQKLSSLGLS TNGTRQNMIK RYNHYEMLWN SNFCDSLEPV  60
   61 DEAELKRQLL SWDVSHN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 9.055517
Match: PF02037
Description: SAP domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.562 N/A N/A a.140.3 Rho termination factor, N-terminal domain
View Download 0.557 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.545 N/A N/A a.112.1 Description not found.
View Download 0.545 N/A N/A a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.543 N/A N/A a.4.1 Homeodomain-like
View Download 0.536 N/A N/A a.112.1 Description not found.
View Download 0.536 N/A N/A a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.475 N/A N/A a.64.1 Saposin
View Download 0.439 N/A N/A a.112.1 Description not found.
View Download 0.393 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #5
Region A:
Residues: [344-487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTPQNSSNKG GISKLMIMKS NGKSSSYRKL LENFKNDKFN RKGWMVMFRK DFARLIREAK  60
   61 MKIKTGSSDS SGSVGHSNDG DGVEKVQSDQ GTEDQQMEKD QDTVINEDRV AGERNLPNED 120
  121 STDADLSREL MDLNEYSKDP PGNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.338 a.4.1 Homeodomain-like
View Download 0.320 c.23.1 CheY-like
View Download 0.319 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.319 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.298 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.298 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.275 a.40.3 Description not found.
View Download 0.216 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle