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View Structure Prediction Details

Protein: SYP1
Organism: Saccharomyces cerevisiae
Length: 870 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYP1.

Description E-value Query
Range
Subject
Range
SYP1_YEAST - Suppressor of yeast profilin deletion OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SY...
SYP1 - Protein of unknown function that is involved in endocytic site formation; may regulate assembly and ...
0.0 [1..870] [1..870]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-86 [207..870] [5..668]
SYP1_SCHPO - Cytoskeletal protein syp1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=syp1 PE=1 SV=1
SPBC4C3.06 - actin cytoskeletal protein Syp1
4.0E-50 [5..799] [6..742]
SLP1_CLOTM, SLAP... - (Q06852) Cell surface glycoprotein 1 precursor (Outer layer protein B) (S-layer protein 1), Cell sur...
1.0E-49 [66..659] [761..1367]
gi|16554449, gi|... - gi|16554449|ref|NP_003377.1| zonadhesin isoform 3 [Homo sapiens], gi|12667414|gb|AAK01433.1|AF332977...
1.0E-45 [157..722] [471..1029]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEQRTKYAD SILTTKSPYE ATETIRIRLS QVKLLNKDFY LLFKELANLK RNYAQQLRKI  60
   61 IAENEDITKI LNAQMIESNV LTPQEMSAFR FNSLGELRNV WDTVIEELKS DLKSSTEYYN 120
  121 TLDQQVVREL KESVENNTSW RESKDLHSKL 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.716 0.517 cellular bud tip a.1.1 Globin-like
View Download 0.666 0.062 cellular bud tip a.118.9 ENTH/VHS domain
View Download 0.548 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.530 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.492 N/A N/A a.7.4 Smac/diablo
View Download 0.487 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.449 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.447 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.440 N/A N/A a.25.1 Ferritin-like
View Download 0.436 N/A N/A a.25.1 Ferritin-like
View Download 0.435 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.429 N/A N/A a.7.1 Spectrin repeat
View Download 0.421 N/A N/A a.7.4 Smac/diablo
View Download 0.399 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.392 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.364 N/A N/A a.2.5 Prefoldin
View Download 0.361 N/A N/A a.118.16 Testis/brain RNA-binding protein (TB-RBP)
View Download 0.350 N/A N/A a.24.3 Cytochromes
View Download 0.338 N/A N/A a.1.1 Globin-like
View Download 0.332 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.329 N/A N/A a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.320 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.317 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.301 N/A N/A a.26.1 4-helical cytokines
View Download 0.298 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.293 N/A N/A a.19.1 Fertilization protein
View Download 0.274 N/A N/A a.149.1 RNase III endonuclease catalytic domain
View Download 0.273 N/A N/A a.39.1 EF-hand
View Download 0.267 N/A N/A a.25.1 Ferritin-like
View Download 0.256 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.255 N/A N/A a.1.1 Globin-like
View Download 0.251 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.247 N/A N/A a.6.1 Putative DNA-binding domain
View Download 0.246 N/A N/A a.118.16 Testis/brain RNA-binding protein (TB-RBP)
View Download 0.235 N/A N/A a.24.4 Hemerythrin
View Download 0.234 N/A N/A a.1.1 Globin-like
View Download 0.229 N/A N/A a.39.1 EF-hand
View Download 0.228 N/A N/A c.55.1 Actin-like ATPase domain
View Download 0.224 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.222 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.220 N/A N/A a.118.16 Testis/brain RNA-binding protein (TB-RBP)
View Download 0.220 N/A N/A a.7.8 GAT domain
View Download 0.216 N/A N/A a.182.1 GatB/YqeY domain
View Download 0.216 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.215 N/A N/A a.175.1 Orange carotenoid protein, N-terminal domain
View Download 0.214 N/A N/A f.1.1 Colicin
View Download 0.211 N/A N/A a.172.1 Helical scaffold and wing domains of SecA
View Download 0.208 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.206 N/A N/A a.22.1 Histone-fold
View Download 0.204 N/A N/A a.1.1 Globin-like
View Download 0.203 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.202 N/A N/A d.173.1 Methionine synthase activation domain-like

Predicted Domain #2
Region A:
Residues: [151-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKNAASIEHY SKNNENSSHL EEARRQWDQQ SPYLFELFET IDYNRLDTLK NCMLRFQTSF  60
   61 SDYLLNTTKE CETVMTKFLA FEPQSEIDRF AKDASQYNFQ LSSSSKEVVP NNASPASATG 120
  121 ARPVSVSNGA ANTEREKKSP QKDKRKSAFG NIGHRLASAS SSLTHNDLMN NEFSDSTNNS 180
  181 SLKSKKSSHT LRSKVGSIFG RNKTKNKRQQ QSSSNSHIQA SITETPN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [378-604]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSTRVSSTA TSSIYQKQRR PTYSSSKSNN WTPGEASDTP PLPPHATPKN VDAPVTADTP  60
   61 PAQTFTPSEV PPSTPQQSSP PTAKEPDSSN LPKTVPISIS QPPLQPQSKT KPLPVEPASP 120
  121 SISLPTATVD NQPSGQVDSR PLHIRAPALP PSRKQNFIHN RDSQLYDSLP NHGSGATPTS 180
  181 SSLSSIPQER PVSTLSSQIT GELRELNPQA TGSSTSLVGQ SLFQHSS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.75
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [605-730]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDTSQFGLNA SIAEVLNASF KDGMLQNSQL IGEIALNYLP NSVMNSPLPI GINLRINNGA  60
   61 KFEKVILNQA FIERVAPEEF KVNPSFIDSR TLGAIKYSIK EPIAPIVIHP VWRFESHQAS 120
  121 VVLTVK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.436 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.440 a.118.8 TPR-like
View Download 0.610 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.487 a.29.2 Bromodomain
View Download 0.610 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.487 a.29.2 Bromodomain
View Download 0.440 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.440 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.440 a.118.8 TPR-like
View Download 0.436 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.435 d.110.4 SNARE-like
View Download 0.429 a.4.12 TrpR-like
View Download 0.422 d.38.1 Thioesterase/thiol ester dehydrase-isomerase
View Download 0.418 a.118.8 TPR-like
View Download 0.411 d.79.1 YjgF-like
View Download 0.408 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.390 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.380 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.378 a.23.3 Methane monooxygenase hydrolase, gamma subunit
View Download 0.333 d.53.1 Ribosomal protein S3 C-terminal domain
View Download 0.322 a.118.9 ENTH/VHS domain
View Download 0.319 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.314 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.291 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.287 a.4.5 "Winged helix" DNA-binding domain
View Download 0.281 c.116.1 alpha/beta knot
View Download 0.281 a.24.3 Cytochromes
View Download 0.268 a.39.1 EF-hand
View Download 0.267 a.96.1 DNA-glycosylase
View Download 0.266 d.112.1 Phoshotransferase/anion transport protein
View Download 0.259 d.66.1 Alpha-L RNA-binding motif
View Download 0.256 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.255 a.39.1 EF-hand
View Download 0.254 c.3.1 FAD/NAD(P)-binding domain
View Download 0.253 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.250 c.47.1 Thioredoxin-like
View Download 0.248 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.235 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.231 a.182.1 GatB/YqeY domain
View Download 0.231 d.168.1 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
View Download 0.218 d.79.4 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain
View Download 0.211 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.210 c.23.5 Flavoproteins

Predicted Domain #5
Region A:
Residues: [731-870]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPSLPDEIS QIVIEDLVVF VNIDGANATS ALSKPQGSFS KEKKRITWRF KEPVVLTRNG  60
   61 EGQRLIARFI TDGLAHESAK GVITKFTISE TDNVALPHSG AGSGITLTCQ ELDENNPFGG 120
  121 EWLDVNTKRT LTTGNYHGLA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.752 0.399 cellular bud tip b.60.1 Lipocalins
View Download 0.573 0.055 cellular bud tip c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.534 0.015 cellular bud tip c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.752 N/A N/A b.60.1 Lipocalins
View Download 0.573 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.562 N/A N/A b.60.1 Lipocalins
View Download 0.554 N/A N/A b.60.1 Lipocalins
View Download 0.534 N/A N/A c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.462 N/A N/A b.76.2 Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
View Download 0.453 N/A N/A b.60.1 Lipocalins
View Download 0.439 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.370 N/A N/A d.32.1 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
View Download 0.354 N/A N/A c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.329 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.316 N/A N/A d.13.1 HIT-like
View Download 0.308 N/A N/A d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.300 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.296 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.283 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.250 N/A N/A d.131.1 DNA clamp
View Download 0.249 N/A N/A d.157.1 Metallo-hydrolase/oxidoreductase
View Download 0.248 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.232 N/A N/A d.168.1 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
View Download 0.211 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.207 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle