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View Structure Prediction Details

Protein: STP22
Organism: Saccharomyces cerevisiae
Length: 296 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STP22.

Description E-value Query
Range
Subject
Range
STP22 - Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into ...
gi|190406431 - gi|190406431|gb|EDV09698.1| hypothetical protein SCRG_05394 [Saccharomyces cerevisiae RM11-1a]
gi|207347351 - gi|207347351|gb|EDZ73550.1| YCL008Cp-like protein [Saccharomyces cerevisiae AWRI1631]
STP22_YEAST - Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease OS=Sac...
1.0E-80 [1..293] [1..293]
TSG101-PA - The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, F...
9.0E-69 [12..295] [3..279]
gi|1870128 - gi|1870128|emb|CAB06793.1| unknown [Saccharomyces pastorianus]
3.0E-68 [1..293] [1..286]
gi|114636476 - gi|114636476|ref|XP_001173373.1| PREDICTED: tumor susceptibility gene 101 isoform 1 [Pan troglodytes...
TSG101 - tumor susceptibility gene 101
gi|60813968, gi|... - gi|61355217|gb|AAX41115.1| tumor susceptibility gene 101 [synthetic construct], gi|60813968|gb|AAX36...
3.0E-67 [12..288] [2..255]
TS101_MOUSE - Tumor susceptibility gene 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2
4.0E-66 [12..288] [2..256]
gi|9454364 - gi|9454364|gb|AAF87776.1| tumor susceptibility protein 101 [Chelonia mydas]
4.0E-66 [12..288] [2..257]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-41 [67..251] [1481..1669]
ELC_ARATH - Protein ELC OS=Arabidopsis thaliana GN=ELC PE=1 SV=1
4.0E-38 [1..207] [19..203]

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Predicted Domain #1
Region A:
Residues: [1-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANGKISVP EAVVNWLFKV IQPIYNDGRT TFHDSLALLD NFHSLRPRTR VFTHSDGTPQ  60
   61 LLLSIYGTIS TGEDGSSPHS IPVIMWVPSM YPVKPPFISI NLENFDMNTI SSSLPIQEYI 120
  121 DSNGWIALPI LHCWDPAAMN LIMVVQELMS LLHEPPQDQA PSLPPKPNTQ LQQEQNTPPL 180
  181 PPKPKSPHLK PPLPPPPPPQ PASNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 114.9794
Match: 1kppA_
Description: Tumor susceptibility gene 101 (TSG101) UEV domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [206-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLMDMDNTD ISPTNHHEML QNLQTVVNEL YREDVDYVAD KILTRQTVMQ ESIARFHEII  60
   61 AIDKNHLRAV EQAIEQTMHS LNAQIDVLNR K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.955 0.045 protein targeting to vacuole a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.789 0.004 protein targeting to vacuole a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.786 0.004 protein targeting to vacuole a.118.11 Cytochrome c oxidase subunit E
View Download 0.781 0.004 protein targeting to vacuole a.7.6 Ribosomal protein S20
View Download 0.815 N/A N/A d.56.1 GroEL-intermediate domain like
View Download 0.754 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.727 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.647 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.646 N/A N/A a.1.1 Globin-like
View Download 0.633 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.616 N/A N/A a.77.1 DEATH domain
View Download 0.604 N/A N/A a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.588 N/A N/A a.24.3 Cytochromes
View Download 0.552 N/A N/A a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.550 N/A N/A d.79.1 YjgF-like
View Download 0.547 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.542 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.537 N/A N/A a.130.1 Chorismate mutase II
View Download 0.531 N/A N/A a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.528 N/A N/A a.46.1 Methionine synthase domain
View Download 0.508 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.506 N/A N/A a.7.7 BAG domain
View Download 0.501 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.499 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.496 N/A N/A a.77.1 DEATH domain
View Download 0.487 N/A N/A a.1.1 Globin-like
View Download 0.485 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.483 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.470 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.446 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.445 N/A N/A a.1.1 Globin-like
View Download 0.441 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.437 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.432 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.426 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.423 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.422 N/A N/A d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.412 N/A N/A a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.409 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.397 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.390 N/A N/A a.156.1 S13-like H2TH domain
View Download 0.390 N/A N/A a.7.1 Spectrin repeat
View Download 0.385 N/A N/A a.47.2 t-snare proteins
View Download 0.380 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.374 N/A N/A a.2.3 Chaperone J-domain
View Download 0.368 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.367 N/A N/A d.82.2 Frataxin-like
View Download 0.360 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.354 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.350 N/A N/A a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.349 N/A N/A a.4.1 Homeodomain-like
View Download 0.345 N/A N/A a.24.4 Hemerythrin
View Download 0.337 N/A N/A a.1.1 Globin-like
View Download 0.329 N/A N/A a.1.1 Globin-like
View Download 0.328 N/A N/A a.51.1 Cytochrome c oxidase subunit h
View Download 0.325 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.325 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.323 N/A N/A a.7.1 Spectrin repeat
View Download 0.322 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.321 N/A N/A c.103.1 Hypothetical protein MT938 (MTH938)
View Download 0.319 N/A N/A a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.316 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.316 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.315 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.312 N/A N/A a.112.1 Description not found.
View Download 0.309 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.308 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.304 N/A N/A a.2.3 Chaperone J-domain
View Download 0.300 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.300 N/A N/A a.2.7 tRNA-binding arm
View Download 0.299 N/A N/A a.1.1 Globin-like
View Download 0.298 N/A N/A a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.297 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.296 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.296 N/A N/A d.6.1 Prion-like
View Download 0.295 N/A N/A d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.294 N/A N/A a.4.1 Homeodomain-like
View Download 0.292 N/A N/A d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.292 N/A N/A a.39.1 EF-hand
View Download 0.291 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.288 N/A N/A a.74.1 Cyclin-like
View Download 0.286 N/A N/A a.24.3 Cytochromes
View Download 0.283 N/A N/A a.74.1 Cyclin-like
View Download 0.282 N/A N/A a.30.1 ROP protein
View Download 0.280 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.279 N/A N/A a.39.1 EF-hand
View Download 0.278 N/A N/A a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.277 N/A N/A a.16.1 S15/NS1 RNA-binding domain
View Download 0.277 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.275 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.275 N/A N/A a.29.2 Bromodomain
View Download 0.273 N/A N/A a.29.2 Bromodomain
View Download 0.273 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.271 N/A N/A a.24.11 Bacterial GAP domain
View Download 0.268 N/A N/A a.25.1 Ferritin-like
View Download 0.267 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.266 N/A N/A a.2.2 Ribosomal protein L29 (L29p)
View Download 0.262 N/A N/A d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain
View Download 0.261 N/A N/A a.24.3 Cytochromes
View Download 0.257 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.249 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.248 N/A N/A a.29.2 Bromodomain
View Download 0.246 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.244 N/A N/A a.118.8 TPR-like
View Download 0.242 N/A N/A b.82.3 cAMP-binding domain-like
View Download 0.240 N/A N/A a.3.1 Cytochrome c
View Download 0.239 N/A N/A g.2.2 Neurotoxin B-IV
View Download 0.234 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.234 N/A N/A d.204.1 Ribosome binding protein Y (YfiA homologue)
View Download 0.230 N/A N/A b.59.1 XRCC4, N-terminal domain
View Download 0.229 N/A N/A a.25.1 Ferritin-like
View Download 0.228 N/A N/A a.118.1 ARM repeat
View Download 0.227 N/A N/A a.26.1 4-helical cytokines
View Download 0.226 N/A N/A a.19.1 Fertilization protein
View Download 0.226 N/A N/A a.39.1 EF-hand
View Download 0.222 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.220 N/A N/A a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.217 N/A N/A a.59.1 PAH2 domain
View Download 0.215 N/A N/A a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.209 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.209 N/A N/A a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.209 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.206 N/A N/A a.1.1 Globin-like
View Download 0.206 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.206 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.204 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.204 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.203 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.202 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle