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View Structure Prediction Details

Protein: COS2, COS3
Organism: Saccharomyces cerevisiae
Length: 379 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COS2, COS3.

Description E-value Query
Range
Subject
Range
COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-enc...
COS1_YEAST - Protein COS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS1 PE=1 SV=1
580.0 [0..1] [375..1]

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Predicted Domain #1
Region A:
Residues: [1-61]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [62-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WWKLSNNCIY PLIVSLLVLF LGPIFVLVIC GLSRKRSLSK QLIQFCKEIT ENTPSSDPHD  60
   61 WEVVAANLNS YLYENNVWNT KYFFFNAMVC QEAFRTTLLE PFSLKKDK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 52.107905
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [170-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAKVKSFKDS VPYIEEALGV YFTEVEKQWK LFNTEKSWSP VGLEDAKLPK EAYRFKLTWF  60
   61 LKRISNIFML IP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.725 d.58.4 Dimeric alpha+beta barrel
View Download 0.700 d.58.52 Description not found.
View Download 0.694 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.669 a.2.17 Description not found.
View Download 0.669 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.652 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.630 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.619 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.594 f.13.1 Family A G protein-coupled receptor-like
View Download 0.562 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.473 d.52.8 Description not found.
View Download 0.446 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.439 a.159.4 Description not found.

Predicted Domain #4
Region A:
Residues: [242-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLNFLCCIYV SRGMCLLLRT LYLGWILFML VQGFQNIRVL IMSMEHKMQF LSTIINEQES  60
   61 GANGWDEIAR KMNRYLFEKK AWKNEEFFFD GIDCEWFFNH FFYRVLSAKK SMWPLPLNVE 120
  121 LWPYIKEAQL SRSEVLLV

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 59.267606
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.456 N/A N/A a.47.1 STAT
View Download 0.426 N/A N/A d.90.1 NADH oxidase/flavin reductase
View Download 0.426 N/A N/A d.90.1 NADH oxidase/flavin reductase
View Download 0.395 N/A N/A c.129.1 Description not found.
View Download 0.373 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.349 N/A N/A d.379.1 Description not found.
View Download 0.298 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.279 N/A N/A a.24.15 FAD-dependent thiol oxidase
View Download 0.273 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.268 N/A N/A d.110.4 SNARE-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle