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View Structure Prediction Details

Protein: ISW1
Organism: Saccharomyces cerevisiae
Length: 1129 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISW1.

Description E-value Query
Range
Subject
Range
ISW1 - Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase ...
ISW1_YEAST - ISWI chromatin-remodeling complex ATPase ISW1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
0.0 [1..1129] [1..1129]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [4..1129] [18..1143]
gi|14028669 - gi|14028669|gb|AAK52454.1|AF325921_1 DNA-dependent ATPase SNF2H [Mus musculus]
0.0 [56..1097] [49..1050]
gi|11035016 - gi|11035016|gb|AAG01537.2|AF292095_1 imitation switch ISWI [Xenopus laevis]
0.0 [35..1097] [4..1045]
Iswi-PA, Iswi-PB... - The gene Imitation SWI is referred to in FlyBase by the symbol Dmel\Iswi (CG8625, FBgn0011604). It i...
0.0 [92..1057] [30..967]
gi|14091823 - gi|14091823|gb|AAK53826.1|AC011806_3 Putative SWI/SNF related, matrix associated, actin dependent re...
gi|15528681, gi|... - gi|34914698|ref|NP_918696.1| putative DNA-dependent ATPase [Oryza sativa (japonica cultivar-group)],...
0.0 [21..1091] [74..1096]
CHD5 - chromodomain helicase DNA binding protein 5
gi|151555557, gi... - gi|151555557|gb|AAI48804.1| Chromodomain helicase DNA binding protein 5 [synthetic construct], gi|14...
0.0 [2..973] [510..1519]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYMLAIANF HFFKFYTRMR KKHENNSCNE KDKDENLFKI ILAIFLQEKK KYDCISSGSI  60
   61 MTASEEYLEN LKPFQVGLPP HDPESNKKRY LLKDANGKKF DLEGTTKRFE HLLSLSGLFK 120
  121 HF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.821 0.016 chromatin remodeling a.24.16 Nucleotidyltransferase substrate binding subunit/domain

Predicted Domain #2
Region A:
Residues: [123-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IESKAAKDPK FRQVLDVLEE NKANGKGKGK HQDVRRRKTE HEEDAELLKE EDSDDDESIE  60
   61 FQFRESPAYV NGQLRPYQIQ GVNWLVSLHK NKIAGILADE MGLGKTLQTI SFLGYLRYIE 120
  121 KIPGPFLVIA PKSTLNNWLR EINRWTPDVN AFILQGDKEE RAELIQKKLL GCDFDVVIAS 180
  181 YEIIIREKSP LKKINWEYII IDEAHRIKNE ESMLSQVLRE FTSRNRLLIT GTPLQNNLHE 240
  241 LWALLNFLLP DIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1gm5A_
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.1726526166851 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
DNA-dependent ATPase activity 1.23094623498843 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
purine ribonucleotide binding 1.21658213854831 bayes_pls_golite062009
ribonucleotide binding 1.21652144153182 bayes_pls_golite062009
purine nucleotide binding 1.21571071905795 bayes_pls_golite062009
nucleotide binding 1.20347573865566 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
transcription elongation regulator activity 1.11383295816593 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
histone acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.729056749897011 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
structure-specific DNA binding 0.620212706423176 bayes_pls_golite062009
helicase activity 0.6191010101321 bayes_pls_golite062009
microtubule motor activity 0.60036517876321 bayes_pls_golite062009
DNA helicase activity 0.57378485697982 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
DNA clamp loader activity 0.49811753387851 bayes_pls_golite062009
double-stranded DNA binding 0.49000746592281 bayes_pls_golite062009
guanyl nucleotide binding 0.388587892299301 bayes_pls_golite062009
guanyl ribonucleotide binding 0.372638007722845 bayes_pls_golite062009
GTP binding 0.364508542344128 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
centromeric DNA binding 0.322818640526369 bayes_pls_golite062009
ATP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.24825301806267 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
GTPase activity 0.234351968078991 bayes_pls_golite062009
ATP binding 0.1860481660648 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
adenyl ribonucleotide binding 0.152859582615242 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
adenyl nucleotide binding 0.138615225841109 bayes_pls_golite062009
pyrophosphatase activity 0.133017653323467 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [376-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDAQDFDDWF SSESTEEDQD KIVKQLHTVL QPFLLRRIKS DVETSLLPKK ELNLYVGM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [434-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSMQKKWYKK ILEKDLDAVN GSNGSKESKT RLLNIMMQLR KCCNHPYLFD GAEPGPPYTT  60
   61 DEHLVYNAAK LQVLDKLLKK LKEEGSRVLI FSQMSRLLDI LEDYCYFRNY EYCRIDGSTA 120
  121 HEDRIQAIDD YNAPDSKKFV FLLTTRAGGL GINLTSADVV VLYDSDWNPQ ADLQAMDRAH 180
  181 RIGQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [619-990]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQVKVFRLVT DNSVEEKILE RATQKLRLDQ LVIQQNRTSL KKKENKADSK DALLSMIQHG  60
   61 AADVFKSGTS TGSAGTPEPG SGEKGDDIDL DELLLKSENK TKSLNAKYET LGLDDLQKFN 120
  121 QDSAYEWNGQ DFKKKIQRDI ISPLLLNPTK RERKENYSID NYYKDVLNTG RSSTPSHPRM 180
  181 PKPHVFHSHQ LQPPQLKVLY EKERMWTAKK TGYVPTMDDV KAAYGDISDE EEKKQKLELL 240
  241 KLSVNNSQPL TEEEEKMKAD WESEGFTNWN KLEFRKFITV SGKYGRNSIQ AIARELAPGK 300
  301 TLEEVRAYAK AFWSNIERIE DYEKYLKIIE NEEEKIKRVK MQQEALRRKL SEYKNPFFDL 360
  361 KLKHPPSSNN KR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [991-1129]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYSEEEDRFI LLMLFKYGLD RDDVYELVRD EIRDCPLFEL DFYFRSRTPV ELARRGNTLL  60
   61 QCLEKEFNAG IVLDDATKDR MKKEDENGKR IREEFADQTA NEKENVDGVE SKKAKIEDTS 120
  121 NVGTEQLVAE KIPENETTH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle