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View Structure Prediction Details

Protein: ECM2
Organism: Saccharomyces cerevisiae
Length: 364 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECM2.

Description E-value Query
Range
Subject
Range
ECM2 - Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association wit...
SLT11_YEAST - Pre-mRNA-splicing factor SLT11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM2 PE=1...
4.0E-86 [1..364] [1..364]
C3H4_ARATH - Zinc finger CCCH domain-containing protein 4 OS=Arabidopsis thaliana GN=At1g07360 PE=2 SV=1
4.0E-80 [10..284] [20..302]
RBM22 - RNA binding motif protein 22
RBM22_MOUSE - Pre-mRNA-splicing factor RBM22 OS=Mus musculus GN=Rbm22 PE=1 SV=1
gi|73954184 - gi|73954184|ref|XP_546302.2| PREDICTED: similar to RNA binding motif protein 22 [Canis familiaris]
tr|M3WPJ5|M3WPJ5... - RNA binding motif protein 22 OS=Felis catus GN=RBM22 PE=4 SV=1
CCDS34278.1_1 - null
gi|119930522 - gi|119930522|ref|XP_001249809.1| PREDICTED: similar to Pre-mRNA-splicing factor RBM22 (RNA-binding m...
gi|114602891, gi... - gi|114602893|ref|XP_001167209.1| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes], gi|114...
RBM22_MACFA - Pre-mRNA-splicing factor RBM22 OS=Macaca fascicularis GN=RBM22 PE=2 SV=1
gi|208965472, gi... - gi|60654947|gb|AAX32038.1| RNA binding motif protein 22 [synthetic construct], gi|208965472|dbj|BAG7...
gi|109079367 - gi|109079367|ref|XP_001108861.1| PREDICTED: similar to RNA binding motif protein 22 isoform 2 [Macac...
tr|G1T1G7|G1T1G7... - pep:novel chromosome:oryCun2:3:32380281:32388261:-1 gene:ENSOCUG00000011532 transcript:ENSOCUT000000...
1.0E-74 [10..287] [21..309]
gi|12858161 - gi|12858161|dbj|BAB31220.1| unnamed protein product [Mus musculus]
2.0E-74 [10..287] [21..309]
gi|2665654 - gi|2665654|gb|AAB88449.1| polyadenylate binding protein [Petromyzon marinus]
7.0E-72 [100..362] [2..277]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
8.0E-72 [100..362] [2..276]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDEINEPPP NICEQCLGDE ANIRMTKIPQ GSECKICTLP FTLYHFKTSK RSNNIIKTLI  60
   61 CVRCATQRNI CQCCMLDSRW HIPIQLRDHL I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.74860109511336 bayes_pls_golite062009
catalytic activity 0.223774911842048 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [92-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLVNEENVMT EEAKNDMMKR FLSLKNVKLG GAQITSDPSE ADNIVDKLKN ILLRATSDGP  60
   61 STPLIKNTTA LYKNEKGANE VKNLEKYASV DISHILKKLP LNESFLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.154902
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.49612884560266 bayes_pls_golite062009
snRNA binding 3.28448936696877 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
U1 snRNA binding 2.26303528058407 bayes_pls_golite062009
protein binding 1.32954276279597 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [199-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPSTKSFFLY NIDASIPEWK ITDTVSQLLG IKKWKDGNSL SLIVNHKAKC GGLRFQSSEL  60
   61 GERFVSKISE TLVTPKGLKR GVLLIDRFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.154902
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [288-364]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFIIPWSSGF SAASFGTNTA ENIKLSLSLN KLIQLELGLS FPTKSTDNAK NDKKKTSKKV  60
   61 HKDRSKKSKP RANKLTI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.221849
Match: 1l3kA_
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle