YRC Public Data Repository - Protein Structure Prediction

Protein:	AKL1
Organism:	Saccharomyces cerevisiae
Length:	1108 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AKL1.

Description	E-value	Query Range	Subject Range
AKL1_YEAST - Serine/threonine-protein kinase AKL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AKL... AKL1 - Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocyto...	0.0	[1..1108]	[1..1108]
gi\|9845487, gi\|1... - ref\|NP_059672.1\| MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens], gi\|1749794\|...	0.0	[18..759]	[3..687]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[18..759]	[3..687]
MRK2_MOUSE - (Q05512) MAP/microtubule affinity-regulating kinase 2 (EC 2.7.1.37) (Serine/threonine-protein kinase...	0.0	[2..759]	[20..716]
gi\|148225752, gi... - gi\|19698204\|dbj\|BAB86594.1\| serine/threonine kinase [Xenopus laevis], gi\|148225752\|ref\|NP_001080425....	0.0	[7..759]	[28..727]
MARK3_RAT - MAP/microtubule affinity-regulating kinase 3 OS=Rattus norvegicus GN=Mark3 PE=1 SV=1	0.0	[3..759]	[28..739]
gi\|19171502 - gi\|19171502\|emb\|CAC87494.1\| calcium-dependent protein kinase [Solanum lycopersicum]	0.0	[2..555]	[73..548]
CDPKL_ARATH - Calcium-dependent protein kinase 21 OS=Arabidopsis thaliana GN=CPK21 PE=1 SV=1	0.0	[8..558]	[53..526]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSITNGTSRS VSAMGHPAVE RYTPGHIVCV GTHKVEVVNY LAEGGFAQIY VVKFLEYLNE  60
   61 FDNTASVPLK IGDVACLKRV LVQDENGLNE MRNE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [110-133]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YFDSNASRRR DGVQGFEVLL LMEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	248.533179
Match:	1ql6A_
Description:	gamma-subunit of glycogen phosphorylase kinase (Phk)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [95-109]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEVMKKLKGA PNIVQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [134-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPNKSLLD

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [164-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALSISQMHYL PVSLIHRDIK IENVLVDAKN NFKLADFGST STCFP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	248.533179
Match:	1ql6A_
Description:	gamma-subunit of glycogen phosphorylase kinase (Phk)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [142-163]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YMNQRLSTKL TEAEIVKIMY DV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [209-365]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVTTHQDIAL LTQNIYVHTT PQYRSPEMID LYRCLPINEK SDIWALGVFL YKLLFFTTPF  60
   61 EMTGQFAILH SKYEFPVNKY SSKLINLIII MLAENPNLRP NIYQVLYHLC EILNVEVPIE 120
  121 DKYAEGAYNF SKYTQFQNKL QNVQLQMYQL QQKKIMQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	248.533179
Match:	1ql6A_
Description:	gamma-subunit of glycogen phosphorylase kinase (Phk)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [366-470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNKLSDSEEN LLNDMFLSSF EISSKLPMNA SDGHAAVSRI PSQNVGQELE EEKESQSDQR  60
   61 KSTLSEDKSS RTTSNANSSG TANNPQEINT IQSPGIEDKS IFENK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.69897
Match:	1cdmA_
Description:	Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [471-589]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPGELYYPSV SELDTYLDKE LVKQSSDPTI SEQSPRLNTQ SLPQRQKSTS SYSSGGRSMK  60
   61 STSYGAATIG SDEALANEKT AGINKMKQHK SNNPFPKMNV AYHSTNELSN DASNFFLEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.69897
Match:	1cdmA_
Description:	Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [590-1108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQGQRYQQA QNQTGTQGNT FPDESQYQSR VEQQQQQQDQ PKGPANYSQR NFYTGRDRSN  60
   61 KPMQLGGTIA GDSGNRRVNF QNISQNYATN SQSGYLPSQN SPAIPMVRPV ISMNQQQAQQ 120
  121 IQAQQLQAQQ MQAKQQMQAK QQMQVQQQLQ VQQQMQIQNA NNNGTYVSDR TNHTTEDMRN 180
  181 AQGGEPPILA GNSANEPMHS SSKNEALLIE LSPLKEDAGK QSFQDTNEPQ TGGIEDAGGS 240
  241 GTIKGSNNNR NGVLNLSLNE MDLSRDDTGA AVSSFSSSSS SASIQQAKLS GRKGSSKRNN 300
  301 YSTDELGDSM VSSESIDIDL DDARRGKTAE RRPLHNERGH KDQARSSDAS KSNQFKSKDF 360
  361 SSVSTRQPRQ SLDLNFQEVN LSSPTLTQEH RNKNDSPAPN SHHSYRVSPH ASTAITENKR 420
  421 HSTGHELSTR SNGKHETHRT GSKQRHDLER YRHSKDKDSN SSITISTSTP SEMRKSFARA 480
  481 RQSLDLERVR REAMASSASS SGGSNGKRRS FFSVFRSEK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1022-1108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKHETHRTGS KQRHDLERYR HSKDKDSNSS ITISTSTPSE MRKSFARARQ SLDLERVRRE  60
   61 AMASSASSSG GSNGKRRSFF SVFRSEK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits