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View Structure Prediction Details

Protein: UBP14
Organism: Saccharomyces cerevisiae
Length: 803 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBP14.

Description E-value Query
Range
Subject
Range
gi|4507855, gi|1... - gi|4507855|ref|NP_003472.1| Ubiquitin isopeptidase T [Homo sapiens], gi|1008542|gb|AAA78934.1| ubiqu...
0.0 [22..802] [7..832]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
0.0 [22..802] [7..831]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [22..802] [7..855]
UBP5_MOUSE - Ubiquitin carboxyl-terminal hydrolase 5 OS=Mus musculus GN=Usp5 PE=1 SV=1
0.0 [22..802] [7..855]
gi|220948830 - gi|220948830|gb|ACL86958.1| CG12082-PA [synthetic construct]
FBpp0298309, CG1... - This gene is referred to in FlyBase by the symbol Dmel\CG12082 (CG12082, FBgn0035402). It is a prote...
0.0 [22..802] [2..825]
ubp14 - ubiquitin C-terminal hydrolase Ubp14
UBP14_SCHPO - Ubiquitin carboxyl-terminal hydrolase 14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=u...
0.0 [23..802] [1..773]
gi|11993473 - gi|11993473|gb|AAG42755.1|AF302664_1 ubiquitin-specific protease 14 [Arabidopsis thaliana]
0.0 [22..802] [2..795]

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Predicted Domain #1
Region A:
Residues: [1-212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVEMTGKFI QKESPKSFSH SEMAEAVLEN VNVPAVVSKD ECIYCFESPY NEPLALNASP  60
   61 KHSLNICLNC FQATCNRHVP LHIRVTEYAC DTIHSNYLTI AKVEKPKQEN VEENNNNKKI 120
  121 KLQVIETSED DTHNTIWSLQ RFNGENVPRT VLSKSTDSDI SSTALEKIEK ILKAKSQDFE 180
  181 DKKNSWVLEI STCPHTENFQ IPSKPENTVN LN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [213-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QCSSCDLTQN LWLCLHCGNI GCGREQIGID GHSHALDHYR SNNNHPLAIK LGSLSSSTYD  60
   61 LYCYACDDET RFPDNVNLGS ALQIYGINIQ EKIADEKTLV QLQVEQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 30.346787
Match: PF02148
Description: Zn-finger in ubiquitin-hydrolases and other protein

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [319-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NENWQFRMVD SSGKEFEKLS ASKNYGCGLI NLGNSCYLNS VIQSLVNGGV PNWSLDFLG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 9.0
Match: PF00442
Description: No description for PF00442 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [378-501]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKFPLDVVYP DNNLKCQWIK LLNAMKCEPE LYPNGIKPTT FKKCIGQNHQ EFSSNRQQDA  60
   61 MEFLTFLLDL LDKKFFSSSS SGIPNPNDLV RFMMEDRLQC NICGKVKYSY EPTEAIQIPL 120
  121 EEND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.892 0.125 protein deubiquitination a.118.8 TPR-like
View Download 0.835 0.125 protein deubiquitination a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.674 0.125 protein deubiquitination a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.639 0.125 protein deubiquitination f.1.5 Exotoxin A, middle domain
View Download 0.634 0.125 protein deubiquitination a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.622 0.125 protein deubiquitination a.18.1 T4 endonuclease V
View Download 0.613 0.125 protein deubiquitination f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.610 0.125 protein deubiquitination a.24.4 Hemerythrin
View Download 0.598 0.125 protein deubiquitination a.64.1 Saposin
View Download 0.593 0.125 protein deubiquitination a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.590 0.125 protein deubiquitination a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.514 0.125 protein deubiquitination b.60.1 Lipocalins
View Download 0.491 0.125 protein deubiquitination a.5.4 Elongation factor TFIIS domain 2
View Download 0.486 0.125 protein deubiquitination a.4.5 "Winged helix" DNA-binding domain
View Download 0.480 0.125 protein deubiquitination d.55.1 Ribosomal protein L22
View Download 0.478 0.125 protein deubiquitination d.54.1 Enolase N-terminal domain-like
View Download 0.464 0.125 protein deubiquitination a.1.1 Globin-like
View Download 0.444 0.125 protein deubiquitination a.60.9 lambda integrase-like, N-terminal domain
View Download 0.435 0.125 protein deubiquitination d.58.26 GHMP Kinase, C-terminal domain
View Download 0.433 0.125 protein deubiquitination a.74.1 Cyclin-like
View Download 0.432 0.125 protein deubiquitination a.4.5 "Winged helix" DNA-binding domain
View Download 0.427 0.125 protein deubiquitination d.164.1 SMAD MH1 domain
View Download 0.419 0.125 protein deubiquitination a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.412 0.125 protein deubiquitination a.24.17 Group V grass pollen allergen
View Download 0.408 0.125 protein deubiquitination a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.380 0.125 protein deubiquitination b.60.1 Lipocalins
View Download 0.371 0.125 protein deubiquitination d.109.2 C-terminal, gelsolin-like domain of Sec23/24
View Download 0.368 0.125 protein deubiquitination a.22.1 Histone-fold
View Download 0.364 0.125 protein deubiquitination a.133.1 Phospholipase A2, PLA2
View Download 0.358 0.125 protein deubiquitination c.78.2 Aspartate/glutamate racemase
View Download 0.345 0.125 protein deubiquitination f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.345 0.125 protein deubiquitination a.26.1 4-helical cytokines
View Download 0.344 0.125 protein deubiquitination a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.342 0.125 protein deubiquitination a.118.1 ARM repeat
View Download 0.341 0.125 protein deubiquitination f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.339 0.125 protein deubiquitination c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.335 0.125 protein deubiquitination a.4.5 "Winged helix" DNA-binding domain
View Download 0.333 0.125 protein deubiquitination a.79.1 Antitermination factor NusB
View Download 0.331 0.125 protein deubiquitination a.60.9 lambda integrase-like, N-terminal domain
View Download 0.330 0.125 protein deubiquitination d.92.1 Metalloproteases ("zincins"), catalytic domain
View Download 0.327 0.125 protein deubiquitination a.74.1 Cyclin-like
View Download 0.321 0.125 protein deubiquitination d.150.1 4'-phosphopantetheinyl transferase
View Download 0.312 0.125 protein deubiquitination a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.310 0.125 protein deubiquitination a.160.1 Poly(A) polymerase, middle domain
View Download 0.309 0.125 protein deubiquitination a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.307 0.125 protein deubiquitination a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.304 0.125 protein deubiquitination a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.297 0.125 protein deubiquitination a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.292 0.125 protein deubiquitination a.64.1 Saposin
View Download 0.290 0.125 protein deubiquitination a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.289 0.125 protein deubiquitination f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.277 0.125 protein deubiquitination a.112.1 Description not found.
View Download 0.269 0.125 protein deubiquitination c.114.1 YchN-like
View Download 0.269 0.125 protein deubiquitination a.4.5 "Winged helix" DNA-binding domain
View Download 0.267 0.125 protein deubiquitination a.1.1 Globin-like
View Download 0.260 0.125 protein deubiquitination a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.258 0.125 protein deubiquitination a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.257 0.125 protein deubiquitination a.4.1 Homeodomain-like
View Download 0.255 0.125 protein deubiquitination a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.255 0.125 protein deubiquitination a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.253 0.125 protein deubiquitination a.39.1 EF-hand
View Download 0.250 0.125 protein deubiquitination a.39.1 EF-hand
View Download 0.248 0.125 protein deubiquitination a.1.1 Globin-like
View Download 0.248 0.125 protein deubiquitination a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.247 0.125 protein deubiquitination a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.246 0.125 protein deubiquitination d.189.1 PX domain
View Download 0.233 0.125 protein deubiquitination a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.227 0.125 protein deubiquitination a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.221 0.125 protein deubiquitination a.4.5 "Winged helix" DNA-binding domain
View Download 0.219 0.125 protein deubiquitination a.7.6 Ribosomal protein S20
View Download 0.218 0.125 protein deubiquitination d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.211 0.125 protein deubiquitination a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.210 0.125 protein deubiquitination a.2.3 Chaperone J-domain
View Download 0.204 0.125 protein deubiquitination a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #5
Region A:
Residues: [502-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPQDMLERIK AYFEGQTIEF KCANCKEKVT ANKKPGFKSL PQTLILNPIR IRLQNWIPVK  60
   61 TSNELSLPGL IDRDDMLDVS SYLSQGFDPQ TENLLPDEDE 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.470 0.736 protein deubiquitination b.1.1 Immunoglobulin
View Download 0.372 0.110 protein deubiquitination f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.709 0.092 protein deubiquitination b.1.2 Fibronectin type III
View Download 0.215 0.075 protein deubiquitination d.109.1 Actin depolymerizing proteins
View Download 0.455 0.054 protein deubiquitination d.93.1 SH2 domain
View Download 0.434 0.032 protein deubiquitination d.8.1 Urease, gamma-subunit
View Download 0.260 0.019 protein deubiquitination a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.476 0.006 protein deubiquitination d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.520 0.004 protein deubiquitination d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.434 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.418 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.369 N/A N/A d.34.1 DNA-binding domain of Mlu1-box binding protein MBP1
View Download 0.361 N/A N/A g.10.1 Hairpin loop containing domain-like
View Download 0.349 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.304 N/A N/A d.95.2 Homing endonucleases
View Download 0.280 N/A N/A d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.268 N/A N/A d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.230 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.229 N/A N/A d.79.1 YjgF-like
View Download 0.221 N/A N/A c.55.4 Translational machinery components
View Download 0.212 N/A N/A b.1.1 Immunoglobulin
View Download 0.206 N/A N/A b.1.5 Transglutaminase, two C-terminal domains
View Download 0.206 N/A N/A a.118.8 TPR-like

Predicted Domain #6
Region A:
Residues: [602-661]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRSSFTPNQC SISQLIEMGF TQNASVRALF NTGNQDAESA MNWLFQHMDD PDLNDPFVPP  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 6.408935
Match: PF00627
Description: UBA/TS-N domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [662-726]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNVPKKDKRE VDEVSLTSML SMGLNPNLCR KALILNNGDV NRSVEWVFNN MDDDGTFPEP  60
   61 EVPNE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 5.638272
Match: PF00627
Description: UBA/TS-N domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [727-803]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQQQKKDLGY STAKPYALTA VICHKGNSVH SGHYVVFIRK LVADKWKWVL YNDEKLVAAD  60
   61 SIEDMKKNGY IYFYTRC

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 22.124939
Match: PF00443
Description: Ubiquitin carboxyl-terminal hydrolase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle