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View Structure Prediction Details

Protein: FLR1
Organism: Saccharomyces cerevisiae
Length: 548 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FLR1.

Description E-value Query
Range
Subject
Range
FLR1_YEAST - Fluconazole resistance protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FLR1 PE...
FLR1 - Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fl...
0.0 [1..548] [1..548]
gi|223644446, gi... - gi|241956766|ref|XP_002421103.1| multidrug transporter; plasma membrane transporter of the major fac...
gi|2951670 - gi|2951670|emb|CAA12730.1| multidrug transporter [Candida dubliniensis]
1.0E-90 [8..546] [7..556]
YCT4_SCHPO - Uncharacterized transporter C794.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC7...
SPCC794.04c - membrane transporter
5.0E-88 [8..546] [23..544]
gi|3378550 - gi|3378550|emb|CAA76190.1| multidrug resistance protein [Candida albicans]
6.0E-85 [8..546] [7..564]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYTSTYRHT IVVDLLEYLG IVSNLETLQS AREDETRKPE NTDKKECKPD YDIECGPNRS  60
   61 CSESSTDSDS SGSQIEK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.381 a.4.5 "Winged helix" DNA-binding domain
View Download 0.346 a.42.1 MDM2
View Download 0.377 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.381 a.4.5 "Winged helix" DNA-binding domain
View Download 0.377 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.376 a.4.5 "Winged helix" DNA-binding domain
View Download 0.376 a.4.5 "Winged helix" DNA-binding domain
View Download 0.348 d.200.1 Integrin beta tail domain
View Download 0.348 d.200.1 Integrin beta tail domain
View Download 0.346 a.42.1 MDM2
View Download 0.325 a.28.1 ACP-like
View Download 0.286 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.273 a.3.1 Cytochrome c

Predicted Domain #2
Region A:
Residues: [78-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDPFRVDWNG PSDPENPQNW PLLKKSLVVF QIMLLTCVTY MGSSIYTPGQ EYIQEEFHVG  60
   61 HVVATLNLSL YVLGYGLGPI IFSPLSETAR YGRLNLYMVT LFFFMIFQVG CATVHNIGGL 120
  121 IVMRFISGIL CSPSLATGGG TVADIISPEM VPLVLGMWSA GAVAAPVLAP LLGAAMVDAK 180
  181 NWRFIFWLLM WLSAATFILL AFFFPETQHH NILYRRALKL RKETGDDRYY TEQDKLDREV 240
  241 DARTFLINTL YRPLKMIIKE PAILAFDLYI AVAYGCFYLF FEAFPIVFVG IYHFSLVEVG 300
  301 LAYMGFCVGC VLAYGLFGIL NMRIIVPRFR NGTFTPEAFL IVAMCVCWCL PLSLFLFGWT 360
  361 ARVHWILPVI SEVFFVLAVF NIFQATFAYL ATCYPKYVAS VFAGNGFCRA SFACAFPLFG 420
  421 RAMYDNLATK NYPVAWGSSL VGFLTLGLAI IPFILYKYGP SLRTRSSYTE E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1lviA_
Description: No description for 1lviA_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle