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View Structure Prediction Details

Protein: NTH2
Organism: Saccharomyces cerevisiae
Length: 780 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTH2.

Description E-value Query
Range
Subject
Range
TREB_YEAST - Probable trehalase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTH2 PE=1 SV=1
NTH2 - Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellula...
0.0 [1..780] [1..780]
TREA_KLULA - Neutral trehalase OS=Kluyveromyces lactis GN=NTH1 PE=3 SV=1
TREA_KLULA - Neutral trehalase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRR...
0.0 [45..780] [11..753]
TREB_MAGGR - Neutral trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) - Mag...
0.0 [49..776] [8..730]
TREB_NEUCR - Neutral trehalase OS=Neurospora crassa GN=treB PE=2 SV=2
TREB_NEUCR - Neutral trehalase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGS...
0.0 [44..765] [8..727]
gi|49823181, gi|... - gi|49823181|gb|AAT68667.1| neutral trehalase [Metarhizium anisopliae var. anisopliae], gi|11544719|e...
gi|49823181, gi|... - gi|49823181|gb|AAT68667.1| neutral trehalase [Metarhizium anisopliae var. anisopliae], gi|11544719|e...
0.0 [44..776] [3..731]
ntp1 - alpha,alpha-trehalase Ntp1
TREA_SCHPO - Neutral trehalase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ntp1 PE=1 SV=1
0.0 [56..773] [18..722]
TREB_EMENI - Neutral trehalase OS=Emericella nidulans GN=treB PE=3 SV=1
gi|49096624, gi|... - gi|67538930|ref|XP_663239.1| TREB_EMENI NEUTRAL TREHALASE (ALPHA,ALPHA-TREHALASE) (ALPHA,ALPHA-TREHA...
0.0 [44..773] [16..737]
TREA_CANAX - Neutral trehalase OS=Candida albicans GN=NTC1 PE=1 SV=1
0.0 [90..778] [191..906]

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Predicted Domain #1
Region A:
Residues: [1-120]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDFLPKVTE INPPSEGNDG EDNIKPLSSG SEQRPLKEEG QQGGRRHHRR LSSMHEYFDP  60
   61 FSNAEVYYGP ITDPRKQSKI HRLNRTRTMS VFNKVSDFKN GMKDYTLKRR GSEDDSFLSS 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [121-780]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGNRRFYIDN VDLALDELLA SEDTDKNHQI TIEDTGPKVI KVGTANSNGF KHVNVRGTYM  60
   61 LSNLLQELTI AKSFGRHQIF LDEARINENP VDRLSRLITT QFWTSLTRRV DLYNIAEIAR 120
  121 DSKIDTPGAK NPRIYVPYNC PEQYEFYIQA SQMNPSLKLE VEYLPKDITA EYVKSLNDTP 180
  181 GLLALAMEEH VNPSTGERSL VGYPYAVPGG RFNELYGWDS YLMALGLIES NKVDVARGMV 240
  241 EHFIFEIDHY SKILNANRSY YLCRSQPPFL TDMALLVFEK IGGKNNPNAI QLLKRAFRAA 300
  301 IKEYKEVWMS SPRLDSLTGL SCYHSDGIGI PPETEPDHFD TILLPYAEKY NVTLEKLRYL 360
  361 YNEGMIKEPK LDAFFLHDRA VRESGHDTTY RFEGVCAYLA TIDLNSLLYK YEKDIAFVIK 420
  421 EYFGNEYKDE NDGTVTDSEH WEELAELRKT RINKYMWDED SGFFFYYNTK LKCRTSYESA 480
  481 TTFWSLWAGL ATEEQAKITV EKALPQLEML GGLVACTEKS RGPISIDRPI RQWDYPFGWA 540
  541 PHQILAWKGL SAYGYQQVAT RLAYRWLYMI TKSFVDYNGM VVEKYDVTRG TDPHRVDAEY 600
  601 GNQGADFKGV ATEGFGWVNT SYLLGLKYMN NHARRALAAC SPPLPFFNSL KPSEKKLYYL 660
  661 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 1000.0
Match: PF01204
Description: Trehalase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
trehalase activity 4.96737734681829 bayes_pls_golite062009
alpha,alpha-trehalase activity 4.67585600835702 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 2.41255243910528 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.15795475185128 bayes_pls_golite062009
hydrolase activity 1.51256018302478 bayes_pls_golite062009
catalytic activity 1.16285856935495 bayes_pls_golite062009
binding 0.82501412375097 bayes_pls_golite062009
glucan 1,4-alpha-glucosidase activity 0.681871542272872 bayes_pls_golite062009
protein binding 0.31260719357226 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle