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View Structure Prediction Details

Protein: SHP1
Organism: Saccharomyces cerevisiae
Length: 423 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SHP1.

Description E-value Query
Range
Subject
Range
SHP1 - UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and...
gi|151946338 - gi|151946338|gb|EDN64560.1| suppressor of high-copy pp1 [Saccharomyces cerevisiae YJM789]
UBX1_YEAST - UBX domain-containing protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHP1 PE=...
0.0 [1..423] [1..423]
NSF1C_MOUSE - NSFL1 cofactor p47 OS=Mus musculus GN=Nsfl1c PE=1 SV=1
2.0E-90 [1..421] [1..368]
NSF1C_RAT - NSFL1 cofactor p47 OS=Rattus norvegicus GN=Nsfl1c PE=1 SV=1
3.0E-90 [1..421] [1..368]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-82 [3..413] [4..412]
gi|56203342, gi|... - gi|7022811|dbj|BAA91731.1| unnamed protein product [Homo sapiens], gi|56203342|emb|CAI22731.1| NSFL1...
gi|114680501 - gi|114680501|ref|XP_001153830.1| PREDICTED: p47 protein isoform 2 [Pan troglodytes]
3.0E-79 [1..421] [1..337]
PUX5_ARATH - Plant UBX domain-containing protein 5 OS=Arabidopsis thaliana GN=PUX5 PE=1 SV=1
7.0E-78 [3..422] [4..421]
gi|13123659 - gi|13123659|gb|AAK12936.1|AF323104_1 phosphatase-like protein Psc923 [Pisum sativum]
3.0E-77 [2..421] [8..399]
gi|13123657 - gi|13123657|gb|AAK12935.1|AF323103_1 phosphatase-like protein Mtc923 [Medicago truncatula]
6.0E-76 [8..421] [16..404]
UBX3_SCHPO - UBX domain-containing protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubx3 PE=1 ...
ubx3 - UBX domain protein Ubx3
2.0E-64 [5..421] [3..408]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD RREEAHWNRQ  60
   61 QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY LKRKGSTSPE PTKGSSRSGS 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [122-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSRFMSFSD MVRGQADDDD EDQPRNTFAG GETSGLEVTD PSDPNSLLKD LLEKARRGGQ  60
   61 MGAENGFRDD EDHEMGANRF TGRGFRLGST IDAADEVVED NTSQSQRRPE KVTREITFWK 120
  121 EGFQVADGPL YRYDDPANSF YLSELNQGRA PLKLLDVQFG QEVEVNVYKK LDESYKAPTR 180
  181 KLGGFSGQGQ RLGSPIPGES SPAEVPKNET PAAQEQPMP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ubiquitin binding 3.08647023955532 bayes_pls_golite062009
small conjugating protein binding 2.81420954636829 bayes_pls_golite062009
binding 2.2560795328149 bayes_pls_golite062009
protein binding 1.0980671422772 bayes_pls_golite062009
nucleic acid binding 0.603841502857006 bayes_pls_golite062009
hydrolase activity 0.356947688028291 bayes_pls_golite062009
catalytic activity 0.25774924710417 bayes_pls_golite062009
DNA binding 0.227398235412559 bayes_pls_golite062009
transcription regulator activity 0.194425568150525 bayes_pls_golite062009
peptidase activity 0.0141774634963068 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [341-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNEPKQGDTS IQIRYANGKR EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP  60
   61 ISNDETTLKD ADLLNSVVVQ RWA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.071898
Match: 1jruA_
Description: p47
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [313-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGSPIPGESS PAEVPKNETP AAQEQPMPDN EPKQGDTSIQ IRYANGKREV LHCNSTDTVK  60
   61 FLYEHVTSNA NTDPSRNFTL NYAFPIKPIS NDETTLKDAD LLNSVVVQRW A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.221849
Match: 1s3sG
Description: Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.63877637096497 bayes_pls_golite062009
protein binding 1.89134588490127 bayes_pls_golite062009
small conjugating protein ligase activity 1.83465130904364 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.16468510691469 bayes_pls_golite062009
acid-amino acid ligase activity 0.919595189902044 bayes_pls_golite062009
nucleic acid binding 0.383121378043805 bayes_pls_golite062009
hydrolase activity 0.247201449341942 bayes_pls_golite062009
DNA binding 0.0840213088061073 bayes_pls_golite062009
transcription regulator activity 0.0485636215870291 bayes_pls_golite062009
cytoskeletal protein binding 0.00343080662821671 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle