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View Structure Prediction Details

Protein: SEN34
Organism: Saccharomyces cerevisiae
Length: 275 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEN34.

Description E-value Query
Range
Subject
Range
gi|151941395 - gi|151941395|gb|EDN59766.1| tRNA splicing endonuclease subunit [Saccharomyces cerevisiae YJM789]
SEN34 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; S...
SEN34_YEAST - tRNA-splicing endonuclease subunit SEN34 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
3.0E-88 [1..275] [1..275]
gi|10438595 - gi|10438595|dbj|BAB15284.1| unnamed protein product [Homo sapiens]
2.0E-78 [4..274] [12..309]
SEN34_MOUSE - tRNA-splicing endonuclease subunit Sen34 OS=Mus musculus GN=Tsen34 PE=2 SV=2
3.0E-69 [4..274] [12..315]
SEN34_SCHPO - Probable tRNA-splicing endonuclease subunit sen34 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24...
sen34 - tRNA-splicing endonuclease subunit Sen34
6.0E-67 [4..275] [16..284]
ENDA_SULTO - tRNA-splicing endonuclease OS=Sulfolobus tokodaii GN=endA PE=1 SV=1
ENDA_SULTO - tRNA-splicing endonuclease OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) G...
4.0E-32 [162..273] [69..179]
sen2 - tRNA-splicing endonuclease subunit Sen2
SEN2_SCHPO - Probable tRNA-splicing endonuclease subunit sen2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
3.0E-29 [131..258] [210..333]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPLVFDIDH IKLLRKWGIC GVLSGTLPTA AQQNVFLSVP LRLMLEDVLW LHLNNLADVK  60
   61 LIRQEGDEIM EGITLERGAK LSKIVNDRLN KSFEYQRKFK KDEHIAKLKK IGRINDKTTA 120
  121 EELQRLDKSS NNDQLIESSL FIDIANTSM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.338 c.3.1 FAD/NAD(P)-binding domain
View Download 0.338 c.3.1 FAD/NAD(P)-binding domain
View Download 0.353 a.7.4 Smac/diablo
View Download 0.343 a.7.1 Spectrin repeat
View Download 0.402 d.67.3 Ribosome recycling factor, RRF
View Download 0.353 a.7.4 Smac/diablo
View Download 0.366 a.24.1 Apolipoprotein
View Download 0.343 a.7.1 Spectrin repeat
View Download 0.402 d.67.3 Ribosome recycling factor, RRF
View Download 0.366 a.24.1 Apolipoprotein
View Download 0.327 a.172.1 Helical scaffold and wing domains of SecA
View Download 0.298 a.172.1 Helical scaffold and wing domains of SecA
View Download 0.259 a.4.12 TrpR-like
View Download 0.252 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.245 a.25.1 Ferritin-like
View Download 0.223 d.110.4 SNARE-like
View Download 0.203 f.18.1 F1F0 ATP synthase subunit A
View Download 0.200 c.55.1 Actin-like ATPase domain

Predicted Domain #2
Region A:
Residues: [150-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILRDIRSDSD SLSRDDISDL LFKQYRQAGK MQTYFLYKAL RDQGYVLSPG GRFGGKFIAY  60
   61 PGDPLRFHSH LTIQDAIDYH NEPIDLISMI SGARLGTTVK KLWVIGGVAE ETKETHFFSI 120
  121 EWAGFG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.045757
Match: 1a79A_
Description: tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle