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View Structure Prediction Details

Protein: SPC72
Organism: Saccharomyces cerevisiae
Length: 622 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPC72.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
3.0E-65 [4..612] [1267..1865]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
5.0E-65 [4..612] [1268..1866]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-64 [4..612] [284..882]
gi|45383668, gi|... - gi|9800486|gb|AAF99314.1|AF272033_1 fast myosin heavy chain isoform 2 [Gallus gallus], gi|45383668|r...
1.0E-64 [4..612] [1273..1871]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
2.0E-64 [4..612] [1269..1867]
gi|8250661 - gi|8250661|gb|AAB29713.2| myosin heavy chain [Rattus sp.]
4.0E-64 [2..612] [216..820]

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Predicted Domain #1
Region A:
Residues: [1-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRRWIPSGR HLRNNDNTGD DDDSEFTNSM DSGMSIPSLR DSMTTRSSHN DPIKPALMND  60
   61 SNKVKNLEKE LTNAKIKIQV LYEYIRRIPN KDGNAPSLGN DTDFRNSIIE GLNLEINKLK 120
  121 QDLKAKEVEY QDTLQFVQEN LENSESIVNT INHLLSFILT HFNEQDENAH LLDKEERETL 180
  181 EETLELSSDY VLEKMDTLSK FIIQFLQDFL HSKSRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [217-280]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESKQDKEEFL SLAQSSPAGS QLESRDSPSS KEENTDGGYQ NDEIHDSNNH IDTENVMANS  60
   61 TSLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [281-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISAVESRFEK TLDTQLEIVI EILHKEYDQF INSIRLKFEK SQKLEKIIAS KLNEQSHLLD  60
   61 SLELEENSSS VIEKQDHLIS QL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [363-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEKIESQSVL INNLEKLKED IIKMKQNEKV LTKELETQTK INKLKENNWD SYINDLEKQI  60
   61 N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [424-504]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLQIDKSEEF HVIQNQLDKL DLENYQLKNQ LNTLDNQKLI LSQYESNFIK FNQNLLLHLD  60
   61 SIFNILQKIL QESSIAQFDR K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [505-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSIKSVPNA LKNLNLIQPK LESLYTFIET ALESIINSYI SSLISMETPE QPHQQGNELT  60
   61 ATPNKELTLR IEELQRRWIS ERERRKLDAN ASEARIKALE QENESLRSKL FNLSINNP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.577 0.057 mitotic spindle elongation a.24.3 Cytochromes
View Download 0.688 0.023 mitotic spindle elongation a.24.14 FAT domain of focal adhesion kinase
View Download 0.681 0.007 mitotic spindle elongation f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.610 0.007 mitotic spindle elongation a.24.1 Apolipoprotein
View Download 0.543 0.006 mitotic spindle elongation a.7.6 Ribosomal protein S20
View Download 0.535 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.516 N/A N/A a.47.2 t-snare proteins
View Download 0.516 N/A N/A a.29.2 Bromodomain
View Download 0.495 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.470 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.447 N/A N/A a.47.2 t-snare proteins
View Download 0.445 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.418 N/A N/A a.7.1 Spectrin repeat
View Download 0.417 N/A N/A a.4.1 Homeodomain-like
View Download 0.404 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.400 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.399 N/A N/A a.47.2 t-snare proteins
View Download 0.397 N/A N/A a.47.2 t-snare proteins
View Download 0.397 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.381 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.372 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.365 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.361 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.359 N/A N/A a.24.3 Cytochromes
View Download 0.348 N/A N/A a.24.3 Cytochromes
View Download 0.343 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.339 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.338 N/A N/A a.24.4 Hemerythrin
View Download 0.336 N/A N/A d.56.1 GroEL-intermediate domain like
View Download 0.326 N/A N/A a.24.1 Apolipoprotein
View Download 0.323 N/A N/A d.95.2 Homing endonucleases
View Download 0.321 N/A N/A a.24.1 Apolipoprotein
View Download 0.317 N/A N/A a.4.1 Homeodomain-like
View Download 0.315 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.315 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.312 N/A N/A a.130.1 Chorismate mutase II
View Download 0.307 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.307 N/A N/A a.24.1 Apolipoprotein
View Download 0.304 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.301 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.301 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.300 N/A N/A d.198.1 Type III secretory system chaperone
View Download 0.297 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.296 N/A N/A a.74.1 Cyclin-like
View Download 0.295 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.286 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.285 N/A N/A d.56.1 GroEL-intermediate domain like
View Download 0.281 N/A N/A a.7.1 Spectrin repeat
View Download 0.279 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.276 N/A N/A d.6.1 Prion-like
View Download 0.275 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.274 N/A N/A a.7.7 BAG domain
View Download 0.271 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.268 N/A N/A b.91.1 E2 regulatory, transactivation domain
View Download 0.268 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.268 N/A N/A d.2.1 Lysozyme-like
View Download 0.267 N/A N/A a.1.1 Globin-like
View Download 0.266 N/A N/A a.24.3 Cytochromes
View Download 0.266 N/A N/A a.1.1 Globin-like
View Download 0.260 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.253 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.252 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.252 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.250 N/A N/A d.110.4 SNARE-like
View Download 0.248 N/A N/A a.63.1 Apolipophorin-III
View Download 0.244 N/A N/A d.52.7 Ribosome-binding factor A, RbfA
View Download 0.243 N/A N/A a.22.1 Histone-fold
View Download 0.239 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.237 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.236 N/A N/A a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.236 N/A N/A a.29.2 Bromodomain
View Download 0.234 N/A N/A a.74.1 Cyclin-like
View Download 0.233 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.230 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.228 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.223 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.223 N/A N/A a.7.1 Spectrin repeat
View Download 0.219 N/A N/A g.44.1 RING/U-box
View Download 0.219 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.219 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.218 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.218 N/A N/A d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.217 N/A N/A a.18.1 T4 endonuclease V
View Download 0.216 N/A N/A a.24.12 Outer surface protein C (OspC)
View Download 0.216 N/A N/A a.47.2 t-snare proteins
View Download 0.214 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.214 N/A N/A d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.212 N/A N/A a.24.3 Cytochromes
View Download 0.211 N/A N/A a.24.1 Apolipoprotein
View Download 0.210 N/A N/A a.1.1 Globin-like
View Download 0.209 N/A N/A a.25.1 Ferritin-like
View Download 0.209 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.208 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.206 N/A N/A a.7.7 BAG domain
View Download 0.205 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.201 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.201 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.201 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle