YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: NTG1
Organism: Saccharomyces cerevisiae
Length: 399 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTG1.

Description E-value Query
Range
Subject
Range
NTH1_YEAST - Endonuclease III homolog 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTG1 PE=1 SV=...
NTG1 - DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in bot...
gi|207347995 - gi|207347995|gb|EDZ73989.1| YAL015Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..399] [1..399]
gi|17380754, gi|... - gi|20259623|gb|AAM14168.1| putative endonuclease [Arabidopsis thaliana], gi|17380754|gb|AAL36207.1| ...
4.0E-77 [8..337] [60..361]
gi|229903773, gi... - gi|229903773|ref|ZP_04518886.1| adenine DNA glycosylase [Yersinia pestis Nepal516], gi|229679543|gb|...
gi|15979021, gi|... - gi|218928123|ref|YP_002345998.1| adenine DNA glycosylase [Yersinia pestis CO92], gi|16121255|ref|NP_...
gi|25292160 - pir||AH0116 A/G-specific adenine glycosylase (EC 3.2.2.-) [imported] - Yersinia pestis (strain CO92)
gi|149290654, gi... - gi|149367040|ref|ZP_01889073.1| A/G-specific adenine glycosylase [Yersinia pestis CA88-4125], gi|149...
gi|229837648, gi... - gi|229837648|ref|ZP_04457810.1| adenine DNA glycosylase [Yersinia pestis Pestoides A], gi|229704336|...
gi|229842567, gi... - gi|229842567|ref|ZP_04462722.1| adenine DNA glycosylase [Yersinia pestis biovar Orientalis str. Indi...
gi|229697238, gi... - gi|229840872|ref|ZP_04461031.1| adenine DNA glycosylase [Yersinia pestis biovar Orientalis str. PEXU...
7.0E-64 [102..384] [2..247]
MUTY_ECOLI - A/G-specific adenine glycosylase (EC 3.2.2.-) - Escherichia coli
EG10627 - adenine DNA glycosylase / Adenine DNA glycosylase, G-A mismatched DNA repair; 2-hydroxyadenine glyco...
gi|89109738, gi|... - gi|89109738|ref|AP_003518.1| adenine DNA glycosylase [Escherichia coli str. K-12 substr. W3110], gi|...
gi|169753726, gi... - gi|170018798|ref|YP_001723752.1| adenine DNA glycosylase [Escherichia coli ATCC 8739], gi|169753726|...
gi|75515259 - gi|75515259|ref|ZP_00737443.1| COG1194: A/G-specific DNA glycosylase [Escherichia coli 53638]
gi|169890348, gi... - gi|170082513|ref|YP_001731833.1| adenine DNA glycosylase [Escherichia coli str. K-12 substr. DH10B],...
gi|75196910 - gi|75196910|ref|ZP_00706980.1| COG1194: A/G-specific DNA glycosylase [Escherichia coli HS]
EG10627 - adenine DNA glycosylase / Adenine DNA glycosylase, G-A mismatched DNA repair; 2-hydroxyadenine glyco...
gi|124526139, gi... - gi|124526139|ref|ZP_01698144.1| A/G-specific adenine glycosylase [Escherichia coli B], gi|124502243|...
gi|238859929, gi... - gi|238902083|ref|YP_002927879.1| adenine DNA glycosylase [Escherichia coli BW2952], gi|238859929|gb|...
gi|242378487, gi... - gi|251786214|ref|YP_003000518.1| hypothetical protein B21_02754 [Escherichia coli BL21], gi|24237848...
gi|254289631, gi... - gi|254289631|ref|YP_003055379.1| adenine DNA glycosylase [Escherichia coli BL21(DE3)], gi|253978938|...
gi|253974772, gi... - gi|254162871|ref|YP_003045979.1| adenine DNA glycosylase [Escherichia coli B str. REL606], gi|253974...
8.0E-64 [106..383] [6..246]
gi|213609558 - gi|213609558|ref|ZP_03369384.1| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar...
gi|213425494 - gi|213425494|ref|ZP_03358244.1| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar...
gi|214000587 - gi|214000587|ref|ZP_03411322.1| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar...
gi|213850187 - gi|213850187|ref|ZP_03381085.1| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar...
gi|213646177 - gi|213646177|ref|ZP_03376230.1| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar...
gi|16761886 - gi|16761886|ref|NP_457503.1| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar Ty...
gi|25292161, gi|... - gi|25292161|pir||AG0879 A/G-specific adenine glycosylase STY3265 [imported] - Salmonella enterica su...
gi|29143373, gi|... - gi|29143373|ref|NP_806715.1| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar Ty...
3.0E-63 [106..383] [6..246]
MUTY_SALTY - A/G-specific adenine glycosylase OS=Salmonella typhimurium GN=mutY PE=3 SV=1
MUTY_SALTY - Adenine DNA glycosylase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=mutY PE=3...
MUTY_SALTY - A/G-specific adenine glycosylase OS=Salmonella typhimurium GN=mutY PE=3 SV=1
lcl|NC_016856.1_... - [gene=mutY] [protein=adenine DNA glycosylase] [protein_id=YP_005239257.1] [location=3287807..3288859...
gi|167990362, gi... - gi|205331157|gb|EDZ17921.1| A/G-specific adenine glycosylase [Salmonella enterica subsp. enterica se...
gi|198243866, gi... - gi|198243866|ref|YP_002217085.1| A/G-specific adenine glycosylase [Salmonella enterica subsp. enteri...
5.0E-63 [106..383] [6..246]

Back

Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKISKYSSM AILRKRPLVK TETGPESELL PEKRTKIKQE EVVPQPVDID WVKSLPNKQY  60
   61 FEWIVVRNGN VPNRWATPLD PSILVTPAST KVPYKFQETY ARMRVLRSKI LAPVDIIGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [120-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSIPVTVASK CGI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [245-399]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AYLTLQKAWG KIEGICVDVH VDRLTKLWKW VDAQKCKTPD QTRTQLQNWL PKGLWTEING  60
   61 LLVGFGQIIT KSRNLGDMLQ FLPPDDPRSS LDWDLQSQLY KEIQQNIMSY PKWVKYLEGK 120
  121 RELNVEAEIN VKHEEKTVEE TMVKLENDIS VKVED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 128.751666
Match: 2abk__
Description: Endonuclease III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA N-glycosylase activity 4.8124964619976 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 4.26870112679392 bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity 3.71152530486175 bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity 2.49872706126491 bayes_pls_golite062009
hydrolase activity 2.39042189031819 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.24777884454113 bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 2.21048599823382 bayes_pls_golite062009
catalytic activity 2.13345932727422 bayes_pls_golite062009
alkylbase DNA N-glycosylase activity 1.5832578018127 bayes_pls_golite062009
DNA binding 1.44394874535958 bayes_pls_golite062009
nucleic acid binding 1.36800347239439 bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity 1.32985950765371 bayes_pls_golite062009
damaged DNA binding 1.32391480975295 bayes_pls_golite062009
binding 1.15752946565805 bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity 1.06383943982125 bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity 0.889914753262716 bayes_pls_golite062009
uracil DNA N-glycosylase activity 0.879508131574476 bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity 0.68578837518217 bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity 0.661651574677137 bayes_pls_golite062009
transcription regulator activity 0.493252955870142 bayes_pls_golite062009
structure-specific DNA binding 0.32094102946624 bayes_pls_golite062009
protein binding 0.0921713980805489 bayes_pls_golite062009
carbon-oxygen lyase activity 0.0676784802238829 bayes_pls_golite062009
double-stranded DNA binding 0.0420287478494503 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [133-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKEQISPRDY RLQVLLGVML SSQTKDEVTA MAMLNIMRYC IDELHSEEGM TLEAVLQINE  60
   61 TKLDELIHSV GFHTRKAKYI LSTCKILQDQ FSSDVPATIN ELLGLPGVGP KM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 128.751666
Match: 2abk__
Description: Endonuclease III
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle