YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|61680400, gi\|...
Organism:	Escherichia coli
Length:	295 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|61680400, gi|....

Description	E-value	Query Range	Subject Range
gi\|46915335, gi\|... - gi\|54301915\|ref\|YP_131908.1\| 2-methylisocitrate lyase [Photobacterium profundum SS9], gi\|46915335\|em...	305.0	[0..4]	[291..2]
gi\|90409987, gi\|... - gi\|90409987\|ref\|ZP_01218004.1\| putative carboxyphosphonoenolpyruvate phosphonomutase [Photobacterium...	304.0	[0..4]	[291..2]
gi\|94500804, gi\|... - gi\|94500804\|ref\|ZP_01307333.1\| PEP phosphonomutase and related enzyme [Oceanobacter sp. RED65], gi\|9...	303.0	[0..4]	[295..5]
gi\|76792554, gi\|... - gi\|76792554\|ref\|ZP_00775052.1\| carboxyphosphonoenolpyruvate phosphonomutase [Pseudoalteromonas atlan...	303.0	[0..4]	[295..2]
gi\|114770708, gi... - gi\|114770708\|ref\|ZP_01448198.1\| putative methylisocitrate lyase [alpha proteobacterium HTCC2255], gi... gi\|114770708 - gi\|114770708\|ref\|ZP_01448198.1\| putative methylisocitrate lyase [alpha proteobacterium HTCC2255] gi\|221133519 - gi\|221133519\|ref\|ZP_03559824.1\| 2-methylisocitrate lyase [Glaciecola sp. HTCC2999]	302.0	[0..4]	[295..2]
gi\|86164789, gi\|... - gi\|87120087\|ref\|ZP_01075983.1\| putative methylisocitrate lyase [Marinomonas sp. MED121], gi\|86164789...	300.0	[0..4]	[295..11]
gi\|69948997, gi\|... - gi\|69948997\|ref\|ZP_00637057.1\| methylisocitrate lyase [Shewanella frigidimarina NCIMB 400], gi\|69166...	299.0	[0..4]	[295..2]
gi\|91715022, gi\|... - gi\|91793020\|ref\|YP_562671.1\| 2-methylisocitrate lyase [Shewanella denitrificans OS217], gi\|91715022\|...	298.0	[0..4]	[295..2]
gi\|88774270, gi\|... - gi\|88794504\|ref\|ZP_01110212.1\| putative methylisocitrate lyase [Alteromonas macleodii 'Deep ecotype'...	298.0	[0..4]	[294..2]
PRPB_ECOLI - (P77541) Methylisocitrate lyase (EC 4.1.3.30) (2-methylisocitrate lyase)	298.0	[0..1]	[293..1]

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Predicted Domain #1

Region A:
Residues: [1-295]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLHSPGKAFR AALTKENPLQ IVGTINANHA LLAQRAGYQA IYLSGGGVAA GSLGLPDLGI  60
   61 STLDDVLTDI RRITDVCSLP LLVDADIGFG SSAFNVARTV KSMIKAGAAG LHIEDQVGAK 120
  121 RSGHRPNKAI VSKEEMVDRI RAAVDAKTDP DFVIMARTDA LAVEGLDAAI ERAQAYVEAG 180
  181 AEMLFPEAIT ELAMYRQFAD AVQVPILANI TEFGATPLFT TDELRSAHVA MALYPLSAFR 240
  241 AMNRAAEHVY NVLRQEGTQK SVIDTMQTRN ELYESINYYQ YEEKLDNLFA RSQVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.0
Match:	1mumA
Description:	2-methylisocitrate lyase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.96882793316847	bayes_pls_golite062009
methylisocitrate lyase activity	2.09739770469711	bayes_pls_golite062009
citrate (pro-3S)-lyase activity	0.86095690814621	bayes_pls_golite062009
lyase activity	0.70986506551964	bayes_pls_golite062009
transferase activity	0.5687068385416	bayes_pls_golite062009
oxo-acid-lyase activity	0.404868472347919	bayes_pls_golite062009
carbon-carbon lyase activity	0.36217387205482	bayes_pls_golite062009
carboxyvinyl-carboxyphosphonate phosphorylmutase activity	0.2132734143313	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: