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View Structure Prediction Details

Protein: WEE1_ARATH
Organism: Arabidopsis thaliana
Length: 500 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WEE1_ARATH.

Description E-value Query
Range
Subject
Range
PAK3 - p21 (CDKN1A)-activated kinase 3
PAK3_PANTR - Serine/threonine-protein kinase PAK 3 OS=Pan troglodytes GN=PAK3 PE=2 SV=1
PAK3_PONPY - Serine/threonine-protein kinase PAK 3 OS=Pongo pygmaeus GN=PAK3 PE=2 SV=1
324.0 [0..3] [499..41]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEKNGRTLL AKRKTQGTIK TRASKKIRKM EGTLERHSLL QFGQLSKISF ENRPSSNVAS  60
   61 SAFQGLLDSD SSELRNQLGS ADSDANCGEK DFILSQDFFC TPDYITPDNQ NLMSGLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1f3mA
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [118-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISKDHSPCPR SPVKLNTVKS KRCRQESFTG NHSNSTWSSK HRVDEQENDD IDTDEVMGDK  60
   61 LQANQTERTG YVSQAAVALR CRAMPPPCLK NPYVLNQSET ATDPFGHQRS KCASFLPVST 120
  121 SGD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [241-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLSRYLTDFH EIRQIGAGHF SRVFKVLKRM DGCLYAVKHS TRKLYLDSER RKAMMEVQAL  60
   61 AALGFHENIV GYYSSWFENE QLYIQLELCD HSLSALPKKS SLKVSEREIL VIMHQIAKAL 120
  121 HFVHEKGIAH LDVKPDNIYI KNGVCKLGDF GCATRLDKSL PVEEGDARYM PQEILNEDYE 180
  181 HLDKVDIFSL GVTVYELIKG SPLTESRNQS LNIKEGKLPL LPGHSLQLQQ LLKTMMDRDP 240
  241 KRRPSARELL DHPMFDRIRG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.69897
Match: 1x8bA
Description: Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle