YRC Public Data Repository - Protein Structure Prediction

Protein:	DLD_ECOLI
Organism:	Escherichia coli
Length:	571 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DLD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194414825, gi... - gi\|75211550\|ref\|ZP_00711629.1\| COG0277: FAD/FMN-containing dehydrogenases [Escherichia coli B171], g...	426.0	[0..1]	[571..1]
gi\|82543547, gi\|... - gi\|82543547\|ref\|YP_407494.1\| D-lactate dehydrogenase [Shigella boydii Sb227], gi\|81244958\|gb\|ABB6566...	425.0	[0..1]	[571..1]
gi\|110615660, gi... - gi\|110806112\|ref\|YP_689632.1\| D-lactate dehydrogenase [Shigella flexneri 5 str. 8401], gi\|110615660\|... gi\|24052566, gi\|... - gi\|24113524\|ref\|NP_708034.1\| D-lactate dehydrogenase [Shigella flexneri 2a str. 301], gi\|24052566\|gb... gi\|30063580, gi\|... - gi\|30063580\|ref\|NP_837751.1\| D-lactate dehydrogenase [Shigella flexneri 2a str. 2457T], gi\|30041833\|...	425.0	[0..1]	[571..1]
gi\|226237488 - gi\|226237488\|dbj\|BAH47010.1\| D-lactate dehydrogenase, FAD-binding, NADH independent [Escherichia col... gi\|209766414 - gi\|209766414\|gb\|ACI81519.1\| D-lactate dehydrogenase [Escherichia coli] gi\|190904523, gi... - gi\|191165360\|ref\|ZP_03027202.1\| D-lactate dehydrogenase [Escherichia coli B7A], gi\|190904523\|gb\|EDV6... gi\|209919592, gi... - gi\|209919592\|ref\|YP_002293676.1\| D-lactate dehydrogenase [Escherichia coli SE11], gi\|209912851\|dbj\|B... gi\|75259606, gi\|... - gi\|75259606\|ref\|ZP_00730908.1\| COG0277: FAD/FMN-containing dehydrogenases [Escherichia coli E22], gi... gi\|187732193, gi... - gi\|187732193\|ref\|YP_001879538.1\| D-lactate dehydrogenase [Shigella boydii CDC 3083-94], gi\|187429185... gi\|193070495, gi... - gi\|75234704\|ref\|ZP_00719024.1\| COG0277: FAD/FMN-containing dehydrogenases [Escherichia coli E110019]... gi\|75186923, gi\|... - gi\|75186923\|ref\|ZP_00700190.1\| COG0277: FAD/FMN-containing dehydrogenases [Escherichia coli E24377A]...	424.0	[0..1]	[571..1]
gi\|190909737, gi... - gi\|75242951\|ref\|ZP_00726657.1\| COG0277: FAD/FMN-containing dehydrogenases [Escherichia coli F11], gi... gi\|110642342, gi... - gi\|110642342\|ref\|YP_670072.1\| D-lactate dehydrogenase [Escherichia coli 536], gi\|110343934\|gb\|ABG701...	424.0	[0..1]	[571..1]
gi\|254593426, gi... - gi\|254794026\|ref\|YP_003078863.1\| D-lactate dehydrogenase, FAD-binding, NADH independent [Escherichia... gi\|209766412, gi... - pir\|\|E85850 D-lactate dehydrogenase [imported] - Escherichia coli (strain O157:H7, substrain EDL933... gi\|12516441, gi\|... - gi\|15802683\|ref\|NP_288710.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|12516441\|... gi\|15832274, gi\|... - gi\|15832274\|ref\|NP_311047.1\| D-lactate dehydrogenase [Escherichia coli O157:H7], gi\|13362489\|dbj\|BAB... gi\|15832274, gi\|... - gi\|15832274\|ref\|NP_311047.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. Sakai], gi\|13362... gi\|217326875, gi... - gi\|217326875\|ref\|ZP_03442958.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. TW14588], gi\|... gi\|209161728, gi... - gi\|209400328\|ref\|YP_002271536.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4115], gi\|... gi\|168801186, gi... - gi\|189376616\|gb\|EDU95032.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC508], gi\|168801... gi\|189371397, gi... - gi\|189371397\|gb\|EDU89813.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC869], gi\|168788... gi\|188999038, gi... - gi\|188999038\|gb\|EDU68024.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4076], gi\|16878... gi\|187767435, gi... - gi\|187767435\|gb\|EDU31279.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4196], gi\|16877... gi\|208742053, gi... - gi\|208821930\|ref\|ZP_03262250.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4042], gi\|2... gi\|208735349, gi... - gi\|208814072\|ref\|ZP_03255401.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4045], gi\|2... gi\|208806248, gi... - gi\|208806248\|ref\|ZP_03248585.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4206], gi\|2... gi\|195935504 - gi\|195935504\|ref\|ZP_03080886.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4024] gi\|168771599, gi... - gi\|189359703\|gb\|EDU78122.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4486], gi\|16877... gi\|168764224, gi... - gi\|189365752\|gb\|EDU84168.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4501], gi\|16876... gi\|168757707, gi... - gi\|189355329\|gb\|EDU73748.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4401], gi\|16875... gi\|168750505, gi... - gi\|188015303\|gb\|EDU53425.1\| D-lactate dehydrogenase [Escherichia coli O157:H7 str. EC4113], gi\|16875...	423.0	[0..1]	[571..1]
gi\|75196178, gi\|... - gi\|75196178\|ref\|ZP_00706248.1\| COG0277: FAD/FMN-containing dehydrogenases [Escherichia coli HS], gi\|... gi\|188495749, gi... - gi\|188495749\|ref\|ZP_03003019.1\| putative D-lactate dehydrogenase [Escherichia coli 53638], gi\|188490...	423.0	[0..1]	[571..1]
gi\|82777385, gi\|... - gi\|82777385\|ref\|YP_403734.1\| D-lactate dehydrogenase [Shigella dysenteriae Sd197], gi\|81241533\|gb\|AB...	423.0	[0..1]	[571..1]
gi\|26248512, gi\|... - gi\|26248512\|ref\|NP_754552.1\| D-lactate dehydrogenase [Escherichia coli CFT073], gi\|26108917\|gb\|AAN81...	423.0	[0..1]	[571..12]
gi\|73856134, gi\|... - gi\|74312657\|ref\|YP_311076.1\| D-lactate dehydrogenase [Shigella sonnei Ss046], gi\|73856134\|gb\|AAZ8884...	423.0	[0..1]	[571..1]

Back

Predicted Domain #1

Region A:
Residues: [1-571]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSMTTTDNK AFLNELARLV GSSHLLTDPA KTARYRKGFR SGQGDALAVV FPGSLLELWR  60
   61 VLKACVTADK IILMQAANTG LTEGSTPNGN DYDRDVVIIS TLRLDKLHVL GKGEQVLAYP 120
  121 GTTLYSLEKA LKPLGREPHS VIGSSCIGAS VIGGICNNSG GSLVQRGPAY TEMSLFARIN 180
  181 EDGKLTLVNH LGIDLGETPE QILSKLDDDR IKDDDVRHDG RHAHDYDYVH RVRDIEADTP 240
  241 ARYNADPDRL FESSGCAGKL AVFAVRLDTF EAEKNQQVFY IGTNQPEVLT EIRRHILANF 300
  301 ENLPVAGEYM HRDIYDIAEK YGKDTFLMID KLGTDKMPFF FNLKGRTDAM LEKVKFFRPH 360
  361 FTDRAMQKFG HLFPSHLPPR MKNWRDKYEH HLLLKMAGDG VGEAKSWLVD YFKQAEGDFF 420
  421 VCTPEEGSKA FLHRFAAAGA AIRYQAVHSD EVEDILALDI ALRRNDTEWY EHLPPEIDSQ 480
  481 LVHKLYYGHF MCYVFHQDYI VKKGVDVHAL KEQMLELLQQ RGAQYPAEHN VGHLYKAPET 540
  541 LQKFYRENDP TNSMNPGIGK TSKRKNWQEV E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	119.0
Match:	1f0xA
Description:	D-lactate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	2.15861884239413	bayes_pls_golite062009
catalytic activity	1.21136912606491	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.85323694965456	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.33475925715446	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: