YRC Public Data Repository - Protein Structure Prediction

Protein:	LPLA_ECOLI
Organism:	Escherichia coli
Length:	338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LPLA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77959218 - gi\|77959218\|ref\|ZP_00823240.1\| COG0095: Lipoate-protein ligase A [Yersinia bercovieri ATCC 43970]	352.0	[0..1]	[338..1]
LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=lplA PE=... lcl\|NC_016856.1_... - [gene=lplA] [protein=lipoate-protein ligase A] [protein_id=YP_005240921.1] [location=complement(4844... gi\|197244278, gi... - gi\|197266023\|ref\|ZP_03166097.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium GN=lplA PE=3 SV=1 LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium GN=lplA PE=3 SV=1 gi\|167989818, gi... - gi\|205331409\|gb\|EDZ18173.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar 4,... gi\|205336596, gi... - gi\|205336596\|gb\|EDZ23360.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar He... LPLA_SALHS - Lipoate-protein ligase A OS=Salmonella heidelberg (strain SL476) GN=lplA PE=3 SV=1	351.0	[0..1]	[338..1]
gi\|77962209 - gi\|77962209\|ref\|ZP_00826032.1\| COG0095: Lipoate-protein ligase A [Yersinia mollaretii ATCC 43969]	349.0	[0..1]	[338..1]
gi\|77975270 - gi\|77975270\|ref\|ZP_00830806.1\| COG0095: Lipoate-protein ligase A [Yersinia frederiksenii ATCC 33641]	348.0	[0..1]	[338..1]
LPLA_YERPS - Lipoate-protein ligase A OS=Yersinia pseudotuberculosis GN=lplA PE=3 SV=1 LPLA_YERPB - Lipoate-protein ligase A OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=lplA PE=3 SV=1 LPLA_YERPS - Lipoate-protein ligase A OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=lplA PE=3 SV=...	348.0	[0..1]	[338..1]
gi\|77980162 - gi\|77980162\|ref\|ZP_00835577.1\| COG0095: Lipoate-protein ligase A [Yersinia intermedia ATCC 29909]	347.0	[0..1]	[338..1]
LPLA_ECOUT - Lipoate-protein ligase A OS=Escherichia coli (strain UTI89 / UPEC) GN=lplA PE=3 SV=1 LPLA_ECOK1 - Lipoate-protein ligase A OS=Escherichia coli O1:K1 / APEC GN=lplA PE=3 SV=1	347.0	[0..1]	[338..1]
gi\|227837954, gi... - gi\|227885125\|ref\|ZP_04002930.1\| lipoate-protein ligase A [Escherichia coli 83972], gi\|227837954\|gb\|E... LPLA_ECOL6 - Lipoate-protein ligase A OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=lplA PE=3... LPLA_ECOL6 - Lipoate-protein ligase A OS=Escherichia coli O6 GN=lplA PE=3 SV=3	347.0	[0..1]	[338..1]
gi\|191167404, gi... - gi\|75229445\|ref\|ZP_00715995.1\| COG0095: Lipoate-protein ligase A [Escherichia coli B7A], gi\|19116740... LPLA_ECOHS - Lipoate-protein ligase A OS=Escherichia coli O9:H4 (strain HS) GN=lplA PE=3 SV=1	347.0	[0..1]	[338..1]
gi\|194439301, gi... - gi\|83585293\|ref\|ZP_00923941.1\| COG0095: Lipoate-protein ligase A [Escherichia coli 101-1], gi\|194439... LPLA_SHISS - Lipoate-protein ligase A OS=Shigella sonnei (strain Ss046) GN=lplA PE=3 SV=1	347.0	[0..1]	[338..1]

Back

Predicted Domain #1

Region A:
Residues: [1-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLRLLISD SYDPWFNLAV EECIFRQMPA TQRVLFLWRN ADTVVIGRAQ NPWKECNTRR  60
   61 MEEDNVRLAR RSSGGGAVFH DLGNTCFTFM AGKPEYDKTI STSIVLNALN ALGVSAEASG 120
  121 RNDLVVKTVE GDRKVSGSAY RETKDRGFHH GTLLLNADLS RLANYLNPDK KKLAAKGITS 180
  181 VRSRVTNLTE LLPGITHEQV CEAITEAFFA HYGERVEAEI ISPNKTPDLP NFAETFARQS 240
  241 SWEWNFGQAP AFSHLLDERF TWGGVELHFD VEKGHITRAQ VFTDSLNPAP LEALAGRLQG 300
  301 CLYRADMLQQ ECEALLVDFP EQEKELRELS AWMAGAVR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.39794
Match:	1x2gA
Description:	Crystal Structure of Lipate-Protein Ligase A from Escherichia coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-oxygen bonds	3.33073922220594	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	3.33073922220594	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	3.33034630936933	bayes_pls_golite062009
ligase activity	3.05852492533937	bayes_pls_golite062009
catalytic activity	2.36416267096403	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: