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View Structure Prediction Details

Protein: hif-1
Organism: Caenorhabditis elegans
Length: 719 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hif-1.

Description E-value Query
Range
Subject
Range
gi|114653415 - gi|114653415|ref|XP_001168628.1| PREDICTED: hypoxia-inducible factor 1, alpha subunit isoform 2 [Pan...
385.0 [0..3] [365..9]

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Predicted Domain #1
Region A:
Residues: [1-74]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDNRKRNME RRRETSRHAA RDRRSKESDI FDDLKMCVPI VEEGTVTHLD RIALLRVAAT  60
   61 ICRLRKTAGN VLEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.154902
Match: 1a0aA
Description: Pho4 B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [75-454]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLDNEITNEV WTEDTIAECL DGFVMIVDSD SSILYVTESV AMYLGLTQTD LTGRALRDFL  60
   61 HPSDYDEFDK QSKMLHKPRG EDTDTTGINM VLRMKTVISP RGRCLNLKSA LYKSVSFLVH 120
  121 SKVSTGGHVS FMQGITIPAG QGTTNANASA MTKYTESPMG AFTTRHTCDM RITFVSDKFN 180
  181 YILKSELKTL MGTSFYELVH PADMMIVSKS MKELFAKGHI RTPYYRLIAA NDTLAWIQTE 240
  241 ATTITHTTKG QKGQYVICVH YVLGIQGAEE SLVVCTDSMP AGMQVDIKKE VDDTRDYIGR 300
  301 QPEIVECVDF TPLIEPEDPF DTVIEPVVGG EEPVKQADMG ARKNSYDDVL QWLFRDQPSS 360
  361 PPPARYRSAD RFRTTEPSNF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.09691
Match: 1wa9A
Description: Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [455-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSALASPDFM DSSSRTSRPK TSYGRRAQSQ GSRTTGSSST SASATLPHSA NYSPLAEGIS  60
   61 QCGLNSPPSI K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [526-719]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGQVVYGDAR SMGRSCDPSD SSRRFSALSP SDTLNVSSTR GINPVIGSND VFSTMPFADS  60
   61 IAIAERIDSS PTLTSGEPIL CDDLQWEEPD LSCLAPFVDT YDMMQMDEGL PPELQALYDL 120
  121 PDFTPAVPQA PAARPVHIDR SPPAKRMHQS GPSDLDFMYT QHYQPFQQDE TYWQGQQQQN 180
  181 EQQPSSYSPF PMLS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle