YRC Public Data Repository - Protein Structure Prediction

Protein:	OTSA_ECOLI
Organism:	Escherichia coli
Length:	474 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OTSA_ECOLI.

Description	E-value	Query Range	Subject Range
TPS1_SCHPO - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Schizosaccharomyces pombe (strain 972 / AT... tps1 - alpha,alpha-trehalose-phosphate synthase [UDP-forming]	384.0	[0..3]	[474..20]
gi\|49527447, gi\|... - gi\|50291407\|ref\|XP_448136.1\| unnamed protein product [Candida glabrata], gi\|49527447\|emb\|CAG61087.1\|... gi\|49527447 - gi\|49527447\|emb\|CAG61087.1\| unnamed protein product [Candida glabrata]	382.0	[0..2]	[452..11]
gi\|44982233 - gi\|44982233\|gb\|AAS51542.1\| ADL378Wp [Ashbya gossypii ATCC 10895] gi\|44982233, gi\|... - gi\|45187495\|ref\|NP_983718.1\| ADL378Wp [Ashbya gossypii ATCC 10895], gi\|44982233\|gb\|AAS51542.1\| ADL37...	381.0	[0..2]	[458..24]
gi\|50423347, gi\|... - gi\|50423347\|ref\|XP_460256.1\| hypothetical protein DEHA0E23210g [Debaryomyces hansenii CBS767], gi\|49... gi\|49655924\|emb\|... - unnamed protein product [Debaryomyces hansenii CBS767]	379.0	[0..2]	[459..4]
gi\|42551067, gi\|... - gi\|46123347\|ref\|XP_386227.1\| hypothetical protein FG06051.1 [Gibberella zeae PH-1], gi\|42551067\|gb\|E...	379.0	[0..2]	[468..83]
gi\|3540 - gi\|3540\|emb\|CAA43580.1\| cif1 [Saccharomyces cerevisiae]	377.0	[0..2]	[451..16]
gi\|32419843, gi\|... - gi\|32419843\|ref\|XP_330365.1\| hypothetical protein [Neurospora crassa], gi\|28920347\|gb\|EAA29718.1\| al... gi\|85091545 - gi\|85091545\|ref\|XP_958954.1\| alpha,alpha-trehalose-phosphate synthase [Neurospora crassa OR74A]	377.0	[0..2]	[465..11]
gi\|83767458 - gi\|83767458\|dbj\|BAE57597.1\| unnamed protein product [Aspergillus oryzae] gi\|169770259 - gi\|169770259\|ref\|XP_001819599.1\| hypothetical protein [Aspergillus oryzae RIB40]	376.0	[0..2]	[468..12]
gi\|109137809 - gi\|109137809\|gb\|ABG25558.1\| trehalose-6-phosphate synthase [Botryotinia fuckeliana]	376.0	[0..2]	[465..13]

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Predicted Domain #1

Region A:
Residues: [1-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRLVVVSNR IAPPDEHAAS AGGLAVGILG ALKAAGGLWF GWSGETGNED QPLKKVKKGN  60
   61 ITWASFNLSE QDLDEYYNQF SNAVLWPAFH YRLDLVQFQR PAWDGYLRVN ALLADKLLPL 120
  121 LQDDDIIWIH DYHLLPFAHE LRKRGVNNRI GFFLHIPFPT PEIFNALPTY DTLLEQLCDY 180
  181 DLLGFQTEND RLAFLDCLSN LTRVTTRSAK SHTAWGKAFR TEVYPIGIEP KEIAKQAAGP 240
  241 LPPKLAQLKA ELKNVQNIFS VERLDYSKGL PERFLAYEAL LEKYPQHHGK IRYTQIAPTS 300
  301 RGDVQAYQDI RHQLENEAGR INGKYGQLGW TPLYYLNQHF DRKLLMKIFR YSDVGLVTPL 360
  361 RDGMNLVAKE YVAAQDPANP GVLVLSQFAG AANELTSALI VNPYDRDEVA AALDRALTMS 420
  421 LAERISRHAE MLDVIVKNDI NHWQECFISD LKQIVPRSAE SQQRDKVATF PKLA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	96.0
Match:	1uqtA
Description:	Trehalose-6-phosphate from E. coli bound with UDP-2-fluoro glucose.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	3.757910581743	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	3.04530122157712	bayes_pls_golite062009
catalytic activity	3.02192459767177	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.94500176353224	bayes_pls_golite062009
trehalose-phosphatase activity	2.37216509261369	bayes_pls_golite062009
glucosyltransferase activity	1.8062586862583	bayes_pls_golite062009
transferase activity	1.67770954408305	bayes_pls_golite062009
UDP-glucosyltransferase activity	1.4199532885636	bayes_pls_golite062009
UDP-glycosyltransferase activity	1.30934991061674	bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity	0.76826617788618	bayes_pls_golite062009
lipopolysaccharide heptosyltransferase activity	0.496539957375041	bayes_pls_golite062009
phosphorylase activity	0.431662083250969	bayes_pls_golite062009
glycogen phosphorylase activity	0.36071680392511	bayes_pls_golite062009
racemase and epimerase activity, acting on carbohydrates and derivatives	0.27693350081385	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: