YRC Public Data Repository - Protein Structure Prediction

Protein:	KPYK2_ECOLI
Organism:	Escherichia coli
Length:	480 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KPYK2_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|82402605, gi\|... - gi\|82499377\|ref\|ZP_00884823.1\| Pyruvate kinase [Caldicellulosiruptor saccharolyticus DSM 8903], gi\|8...	582.0	[0..5]	[479..1]
gi\|114657936 - gi\|114657936\|ref\|XP_001175096.1\| PREDICTED: hypothetical protein isoform 11 [Pan troglodytes]	579.0	[0..6]	[479..103]
gi\|109081748 - gi\|109081748\|ref\|XP_001091427.1\| PREDICTED: pyruvate kinase 3 isoform 9 [Macaca mulatta]	579.0	[0..6]	[479..103]
gi\|237705808, gi... - gi\|237705808\|ref\|ZP_04536289.1\| pyruvate kinase II [Escherichia sp. 3_2_53FAA], gi\|226900565\|gb\|EEH8... gi\|91211079, gi\|... - gi\|91211079\|ref\|YP_541065.1\| pyruvate kinase [Escherichia coli UTI89], gi\|91072653\|gb\|ABE07534.1\| py... gi\|115513130, gi... - gi\|117624006\|ref\|YP_852919.1\| pyruvate kinase [Escherichia coli APEC O1], gi\|115513130\|gb\|ABJ01205.1... gi\|26248120, gi\|... - gi\|26248120\|ref\|NP_754160.1\| pyruvate kinase [Escherichia coli CFT073], gi\|26108523\|gb\|AAN80725.1\|AE...	576.0	[0..1]	[480..48]
gi\|46199913, gi\|... - gi\|46199913\|ref\|YP_005580.1\| pyruvate kinase [Thermus thermophilus HB27], gi\|46197540\|gb\|AAS81953.1\|...	575.0	[0..1]	[479..1]
gi\|55771385, gi\|... - gi\|55979972\|ref\|YP_143269.1\| pyruvate kinase [Thermus thermophilus HB8], gi\|55771385\|dbj\|BAD69826.1\|...	574.0	[0..1]	[479..1]
gi\|33875497 - gi\|33875497\|gb\|AAH00481.2\| PKM2 protein [Homo sapiens]	574.0	[0..6]	[479..77]

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Predicted Domain #1

Region A:
Residues: [1-480]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRRLRRTKI VTTLGPATDR DNNLEKVIAA GANVVRMNFS HGSPEDHKMR ADKVREIAAK  60
   61 LGRHVAILGD LQGPKIRVST FKEGKVFLNI GDKFLLDANL GKGEGDKEKV GIDYKGLPAD 120
  121 VVPGDILLLD DGRVQLKVLE VQGMKVFTEV TVGGPLSNNK GINKLGGGLS AEALTEKDKA 180
  181 DIKTAALIGV DYLAVSFPRC GEDLNYARRL ARDAGCDAKI VAKVERAEAV CSQDAMDDII 240
  241 LASDVVMVAR GDLGVEIGDP ELVGIQKALI RRARQLNRAV ITATQMMESM ITNPMPTRAE 300
  301 VMDVANAVLD GTDAVMLSAE TAAGQYPSET VAAMARVCLG AEKIPSINVS KHRLDVQFDN 360
  361 VEEAIAMSAM YAANHLKGVT AIITMTESGR TALMTSRISS GLPIFAMSRH ERTLNLTALY 420
  421 RGVTPVHFDS ANDGVAAASE AVNLLRDKGY LMSGDLVIVT QGDVMSTVGS TNTTRILTVE 480
  481

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	164.0
Match:	1t5aA
Description:	Human Pyruvate Kinase M2
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits