YRC Public Data Repository - Protein Structure Prediction

Protein:	EG11227
Organism:	Escherichia coli K-12
Length:	1015 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG11227.

Description	E-value	Query Range	Subject Range
FDNG_ECOLI - Formate dehydrogenase, nitrate-inducible, major subunit (EC 1.2.1.2) (Formate dehydrogenase-N subuni... FDNG_ECOLI - Formate dehydrogenase, nitrate-inducible, major subunit - Escherichia coli (strain K12)	929.0	[0..1]	[1015..1]
gi\|26108163, gi\|... - gi\|26247761\|ref\|NP_753801.1\| formate dehydrogenase, nitrate-inducible, major subunit [Escherichia co...	928.0	[0..1]	[1015..1]
gi\|74312160, gi\|... - gi\|74312160\|ref\|YP_310579.1\| formate dehydrogenase-N, nitrate-inducible, alpha subunit [Shigella son... gi\|157066629, gi... - gi\|157160949\|ref\|YP_001458267.1\| formate dehydrogenase, nitrate inducible, alpha subunit, selenocyst...	928.0	[0..1]	[1015..1]
gi\|51598212, gi\|... - gi\|51598212\|ref\|YP_072403.1\| formate dehydrogenase-O, major subunit (formate dehydrogenase... [Yersi...	928.0	[0..1]	[1014..1]
gi\|24113106, gi\|... - gi\|24113106\|ref\|NP_707616.1\| formate dehydrogenase-N, nitrate-inducible, alpha subunit [Shigella fle... gi\|30063229, gi\|... - gi\|30063229\|ref\|NP_837400.1\| formate dehydrogenase-N, nitrate-inducible, alpha subunit [Shigella fle...	927.0	[0..1]	[1015..1]
gi\|218558396, gi... - gi\|218558396\|ref\|YP_002391309.1\| formate dehydrogenase-N, alpha subunit, nitrate-inducible [Escheric... gi\|91210712, gi\|... - gi\|91210712\|ref\|YP_540698.1\| FdnG, alpha subunit of formate dehydrogenase-N [Escherichia coli UTI89]...	927.0	[0..1]	[1015..1]
gi\|110615245, gi... - gi\|110805697\|ref\|YP_689217.1\| formate dehydrogenase-N, nitrate-inducible, alpha subunit [Shigella fl...	927.0	[0..1]	[1015..1]
gi\|13361544, gi\|... - gi\|15831332\|ref\|NP_310105.1\| nitrate-inducible formate dehydrogenase-N alpha subunit [Escherichia co... gi\|12515210, gi\|... - gi\|15801663\|ref\|NP_287681.1\| formate dehydrogenase-N, nitrate-inducible, alpha subunit [Escherichia ... gi\|13361544, gi\|... - gi\|15831332\|ref\|NP_310105.1\| nitrate-inducible formate dehydrogenase-N alpha subunit [Escherichia co...	926.0	[0..1]	[1015..1]
gi\|16420092, gi\|... - gi\|16764914\|ref\|NP_460529.1\| formate dehydorgenase-N alpha subunit [Salmonella typhimurium LT2], gi\|... lcl\|NC_016856.1_... - [gene=fdnG] [protein=formate dehydrogenase-N subunit alpha] [protein_id=YP_005237461.1] [location=co...	926.0	[0..1]	[1015..1]

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Predicted Domain #1

Region A:
Residues: [1-1015]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVSRRQFFK ICAGGMAGTT VAALGFAPKQ ALAQARNYKL LRAKEIRNTC TYCSVGCGLL  60
   61 MYSLGDGAKN AREAIYHIEG DPDHPVSRGA LCPKGAGLLD YVNSENRLRY PEYRAPGSDK 120
  121 WQRISWEEAF SRIAKLMKAD RDANFIEKNE QGVTVNRWLS TGMLCASGAS NETGMLTQKF 180
  181 ARSLGMLAVD NQARVUHGPT VASLAPTFGR GAMTNHWVDI KNANVVMVMG GNAAEAHPVG 240
  241 FRWAMEAKNN NDATLIVVDP RFTRTASVAD IYAPIRSGTD ITFLSGVLRY LIENNKINAE 300
  301 YVKHYTNASL LVRDDFAFED GLFSGYDAEK RQYDKSSWNY QLDENGYAKR DETLTHPRCV 360
  361 WNLLKEHVSR YTPDVVENIC GTPKADFLKV CEVLASTSAP DRTTTFLYAL GWTQHTVGAQ 420
  421 NIRTMAMIQL LLGNMGMAGG GVNALRGHSN IQGLTDLGLL STSLPGYLTL PSEKQVDLQS 480
  481 YLEANTPKAT LADQVNYWSN YPKFFVSLMK SFYGDAAQKE NNWGYDWLPK WDQTYDVIKY 540
  541 FNMMDEGKVT GYFCQGFNPV ASFPDKNKVV SCLSKLKYMV VIDPLVTETS TFWQNHGESN 600
  601 DVDPASIQTE VFRLPSTCFA EEDGSIANSG RWLQWHWKGQ DAPGEARNDG EILAGIYHHL 660
  661 RELYQSEGGK GVEPLMKMSW NYKQPHEPQS DEVAKENNGY ALEDLYDANG VLIAKKGQLL 720
  721 SSFAHLRDDG TTASSCWIYT GSWTEQGNQM ANRDNSDPSG LGNTLGWAWA WPLNRRVLYN 780
  781 RASADINGKP WDPKRMLIQW NGSKWTGNDI PDFGNAAPGT PTGPFIMQPE GMGRLFAINK 840
  841 MAEGPFPEHY EPIETPLGTN PLHPNVVSNP VVRLYEQDAL RMGKKEQFPY VGTTYRLTEH 900
  901 FHTWTKHALL NAIAQPEQFV EISETLAAAK GINNGDRVTV SSKRGFIRAV AVVTRRLKPL 960
  961 NVNGQQVETV GIPIHWGFEG VARKGYIANT LTPNVGDANS QTPEYKAFLV NIEKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1kqfA
Description:	Formate dehydrogenase N, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
formate dehydrogenase activity	12.8557183783781	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	7.57161550681607	bayes_pls_golite062009
oxidoreductase activity	7.18948979839656	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	7.16311737169172	bayes_pls_golite062009
electron carrier activity	2.49660481239302	bayes_pls_golite062009
nitrate reductase activity	2.20600951698793	bayes_pls_golite062009
catalytic activity	1.93875927205186	bayes_pls_golite062009
trimethylamine-N-oxide reductase activity	1.53833487723248	bayes_pls_golite062009
oxidoreductase activity, acting on other nitrogenous compounds as donors	1.12492792673137	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	1.10002765979078	bayes_pls_golite062009
molybdenum ion binding	1.06869099200697	bayes_pls_golite062009
iron-sulfur cluster binding	0.552726587326143	bayes_pls_golite062009
metal cluster binding	0.552726587326143	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.134493772161849	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: