YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|25326080
Organism:	Streptococcus pneumoniae
Length:	263 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25326080.

Description	E-value	Query Range	Subject Range
gi\|27468610, gi\|... - gi\|27468610\|ref\|NP_765247.1\| phosphomethylpyrimidine kinase [Staphylococcus epidermidis ATCC 12228],... gi\|57638290, gi\|... - gi\|57867632\|ref\|YP_189265.1\| phosphomethylpyrimidine kinase [Staphylococcus epidermidis RP62A], gi\|5...	236.0	[0..1]	[261..1]
gi\|28211403, gi\|... - gi\|28211403\|ref\|NP_782347.1\| hydroxymethylpyrimidine kinase [Clostridium tetani E88], gi\|28203844\|gb...	234.0	[0..3]	[260..6]
gi\|106895590, gi... - gi\|158321715\|ref\|YP_001514222.1\| phosphomethylpyrimidine kinase [Alkaliphilus oremlandii OhILAs], gi...	234.0	[0..4]	[259..1]
gi\|22776153, gi\|... - gi\|23097929\|ref\|NP_691395.1\| phosphomethylpyrimidine kinase [Oceanobacillus iheyensis HTE831], gi\|22...	233.0	[0..1]	[263..1]
gi\|110802744, gi... - gi\|110802744\|ref\|YP_698658.1\| phosphomethylpyrimidine kinase [Clostridium perfringens SM101], gi\|110...	232.0	[0..1]	[260..1]
gi\|25326092 - pir\|\|F97951 phosphomethylpyrimidine kinase (EC 2.7.4.7) [imported] - Streptococcus pneumoniae (strai... gi\|15458222, gi\|... - gi\|15902682\|ref\|NP_358232.1\| phosphomethylpyrimidine kinase [Streptococcus pneumoniae R6], gi\|154582... gi\|237821850 - gi\|237821850\|ref\|ZP_04597695.1\| phosphomethylpyrimidine kinase [Streptococcus pneumoniae CCRI 1974M2... gi\|237651010 - gi\|237651010\|ref\|ZP_04525262.1\| phosphomethylpyrimidine kinase [Streptococcus pneumoniae CCRI 1974] gi\|116077129, gi... - gi\|116516553\|ref\|YP_816128.1\| phosphomethylpyrimidine kinase [Streptococcus pneumoniae D39], gi\|1160...	231.0	[0..1]	[263..1]
gi\|151222209, gi... - gi\|151222209\|ref\|YP_001333031.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus... gi\|221141613 - gi\|221141613\|ref\|ZP_03566106.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus ... gi\|87161070, gi\|... - gi\|87161070\|ref\|YP_494695.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus USA... gi\|221137058 - gi\|221137058\|ref\|ZP_03561869.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus ... gi\|87127044\|gb\|A... - phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus USA300], phosphomethylpyrimidine... gi\|57650767, gi\|... - gi\|57650767\|ref\|YP_186901.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus COL... gi\|88195996, gi\|... - gi\|88195996\|ref\|YP_500809.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus NCT...	231.0	[0..1]	[261..1]
gi\|269203729\|ref... - phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus ED98] THID_STAAM - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase OS=Staphylococcus aureus (strain Mu50 / ATCC ... gi\|156722544, gi... - gi\|156980409\|ref\|YP_001442668.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus... THID_STAAN - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase OS=Staphylococcus aureus (strain N315) GN=thi... gi\|90583378, gi\|... - gi\|90583378\|ref\|ZP_01239135.1\| Phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus J... gi\|25326087 - pir\|\|C90002 phosphomethylpyrimidine kinase [imported] - Staphylococcus aureus (strain N315) gi\|90585700, gi\|... - gi\|90585700\|ref\|ZP_01241408.1\| Phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus J... gi\|255006882 - gi\|255006882\|ref\|ZP_05145483.2\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus ...	229.0	[0..1]	[261..1]
gi\|149948927, gi... - gi\|77686688\|ref\|ZP_00802021.1\| Phosphomethylpyrimidine kinase [Alkaliphilus metalliredigenes QYMF], ...	229.0	[0..4]	[260..1]
gi\|227558822, gi... - gi\|227558822\|ref\|ZP_03988869.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus ... gi\|227852200, gi... - gi\|227899566\|ref\|ZP_04017371.1\| phosphomethylpyrimidine kinase [Staphylococcus aureus subsp. aureus ... THID_STAAR - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase OS=Staphylococcus aureus (strain MRSA252) GN=...	229.0	[0..1]	[261..1]

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Predicted Domain #1

Region A:
Residues: [1-263]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYLPVALTI AGTDPSGGAG IMADLKSFQA RDVYGMAVVT SLVAQNTRGV QLIEHVSPQM  60
   61 LKAQLESVFS DIPPQAVKTG MLATTEIMEI IQPYLKKLDC PYVLDPVMVA TSGDALIDSN 120
  121 ARDYLKTNLL PLATIITPNL PEAEEIVGFS IHDPEDMQRA GRLILKEFGP QSVVIKGGHL 180
  181 KGGAKDFLFT KNEQFVWESP RIQTCHTHGT GCTFAAVITA ELAKGKSLYQ AVDKAKAFIT 240
  241 KAIQDAPQLG HGSGPVNHTT FKD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.045757
Match:	1jxhA
Description:	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphomethylpyrimidine kinase activity	4.17236703133163	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	2.49796023165143	bayes_pls_golite062009
catalytic activity	2.11518580948187	bayes_pls_golite062009
transferase activity	1.65599843675995	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.53929419091344	bayes_pls_golite062009
kinase activity	1.44909019943198	bayes_pls_golite062009
thiamin-phosphate diphosphorylase activity	1.41576214895876	bayes_pls_golite062009
hydroxyethylthiazole kinase activity	0.44128654727966	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: